GHS Classification Result

Chemical Name:isobutyl methacrylate
CAS:97-86-9

Result:
ID: 20A2086
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Since its flash point is 35degC (in a closed system) (IUCLID, 2000), which is within guidance values of Category 3 (23 - 60degC). Also, it is rated Class 3, Packing group III in TDG classification, thus the substance is classified into Category 3.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Type G - - - - The substance contains chemical groups (acrylic group, which is an unsaturated bond) associated with self-reactive properties. However, the substance used in the commercially distributed products is mixed with a self-polymerization inhibitor (hydroquinone monomethyl ether), making the products non-self-reactive. Thus, according to the UNRTDG, the product (UN 2283) is rated as Class 3 and the substance is classified into Type G.
9 Pyrophoric liquids Not classified - - - - Since its autoignition point is 390 - 514degC (Hommel, 1996; IUCLID, 2000), which is above 70degC, and it is rated Class 3 in TDG classification (UN No. 2283), the substance was classified into "Not classified".
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Since its LD50 is 6400 - 12800, 9600, and 11824 mg/kg for rats (ECETOC No. 36, 1996), the substance is classified into "Not classified".
1 Acute toxicity (Dermal) Not classified - - - - Since its LD50 > 17760 mg/kg for guinea pigs (IUCLID, 2000), the substance is classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Its 6h-LC50 is 3600 ppm or more (ECETOC JACC No.36, 1996), and 4h-conversion will be approximately 4410 ppm or more. Its vapour pressure is documented to be 3.63 mmHg (25degC) (conversion, 483 Pa (25degC)) (HSDB (2003)) and 4.11 mmHg (25degC) (conversion, 547 Pa (25degC)) (Howard (1997)), and its calculated saturated vapour pressure concentration is 4782 ppm and 5416 ppm, respectively. Since its 6h-LC50 is less than the 90% value of the saturated vapour pressure concentration, the substance is "vapour with almost no included mists." Thus, it would be classified into Category 4 or "Not classified", but it is classified into "Classification not possible" due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
It is documented that in a Draize test the substance was applied for 24 hours to skin of rabbits, well-defined erythema and moderate edema were exhibited (ECETOC JACC No. 36 (1996)). In addition, the substance is rated Xi; R36/37/38 in EU classification. Thus, it was classified into Category 2.
3 Serious eye damage/eye irritation Not classified - - - - Based on a rabbit test (according to OECD Guideline 405, GLP; ECETOC JACC No. 36 (1996)), the substance is classified into "Not classified". Although it is rated Xi; R36/37/38 in EU classification, the substance was classified into "Not classified" based on expert judgement.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - It is rated R43 in the EU classification, and allergic hypersensitivity marked in five persons in a human patch test was evaluated to be ambiguous (IUCLID, 2000). A test using guinea pigs showed negative results (ECETOC JACC No. 36 (1996)). Thus, the substance cannot be classified due to limited data.
5 Germ cell mutagenicity Not classified - - - - Since it was negative in a micronucleus test in mouse bone marrow cells (according to OECD Guideline 474) (ECETOC JACC No. 36 (1996)) (a somatic cell in vivo mutagenicity test), the substance was classified into "Not classified".
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - Although it has been documented that in a developmental toxicity test in which the substance was administered by the i.p. route to rats on day 5, 10, and 15 of gestation, increase of resorption and skeletal abnormalities were observed (ECETOC JACC No. 36 (1996), it has been documented that the control group treated with normal saline and cotton-seed oils also showed skeletal abnormalities, and the i.p. route is not an appropriate route of administration. Thus, the substance was classified into "Classification not possible".
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In a four-hour inhalation test using rats, signs such as decreased motor activity, eye squint, erythema, and slight dyspnea, all of which subsided on the 14th day were observed at doses >= 2 mg/L (being less than 90% of the saturated vapour pressure concentration, and the substance is considered to be vapour) were reported (IUCLID (2000)). However, since no other information is available, the substance cannot be classified due to lack of data.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Since the four-week test via inhalation using rats and the four to six month test via diet feeding (both from PATTY (5th, 2001)) do not provide detailed descriptions on such factors as feeding amount and exposure period, the substance was classified into "Classification not possible" due to lack of data.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its 72h-EC50 = 0.29 mg/L for algae (Pseudokirchn eriella subcapitata) (ECETOC, 1997), the substance was classified into Category 1.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Although its preexisting classification for acute toxicity is Category 1, it is rapidly degradable (28-day degradability of OECD TG 301D = 74.3% (ECETOC, 1997)) and it is estimated to have low potential for bioconcentration (LogPow = 2.66 (ECETOC, 1997)), thus, the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information