Chemical Name：Lead sulfochromate yellow; C.I. Pigment Yellow 34; [This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77603.]
CAS：1344-37-2

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Since the rat LD50 is > 5000mg/kg (OECD TG401, non-GLP) (IUCLID, 2000), the substance was classified into "Not classified".
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Not classified	-	-	-	-	In rabbit tests (OECD TG404, non-GLP), the substance was concluded to be not irritating (IUCLID (2000)). Thus, the substance was classified into "Not classified".
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	In rabbit tests (OECD TG405, non-GLP), the substance was concluded to be not irritating (IUCLID (2000)). Thus, the substance was classified into "Not classified".
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Positive reactions were detected using several indicators in in vitro mutagenicity tests (Ames tests, cytogenetical tests using CHO cells, and sister chromatid exchange tests) (IUCLID, 2000). However, there is no data from in vivo tests, and intensity levels of positive reactions detected in in vitro tests were not specified. As such, the substance was classified into "Classification not possible".
6	Carcinogenicity	Category 1B		Danger	H350: May cause cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Since the IARC has classified the substance into Group 2A as an inorganic lead compound, it was classified into Category 1B. Although rat studies were documented (HSDB, 2005), unconventional administration methods-- the substance was wrapped in stainless steel mesh pellets surgically implanted in the left inferior bronchiolus, were adopted. Thus, these data were disregarded for the classification purpose.
7	Reproductive toxicity	Category 1		Danger	H360: May damage fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Although no test results are available on this substance, it is documented that lead is transferred across the placenta. It can affect reproduction in males and females, and affects neurodevelopmental milestones in children with both prenatal and postnatal exposure. Furthermore, lead intake is documented to affect the sexual functions of both sexes (HSDB, (2005)). According to the EU, the substance is classified into R61 and 62. Based on this information, the substance was classified into Category 1.
8	Specific target organ toxicity - Single exposure	Category 1 (kidney, digestive system, cranial nervous system)		Danger	H370: Causes damage to organs (kidney, digestive system, cranial nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	The classification of this substance was done by reviewing the effects of inorganic lead compounds. In persons whose blood lead level was above 1250 or 1500microg/L after acute lead poisoning, functional disorders of the epithelium of the proximal renal tubules were detected (DFGOT 17 (2002)). In 31 patients with lead poisoning (blood lead levels 400 to 1750microg/L), on the other hand, no clinical signs of kidney damage were seen. (DFGOT vol.17 (2002)). Colic pain is an early symptom of acute poisoning with high concentrations of lead, which often involves symptoms such as abdominal pain, constipation, cramps, nausea, vomiting, anorexia, and weight loss. Exposure to high lead concentrations that cause severe gastrointestinal dysfunction may also cause encephalopathy (ATSDR, 2007). Based on the information, the substance was classified into Category 1 (kidney, digestive system, and cranial nervous system).
9	Specific target organ toxicity - Repeated exposure	Category 1 (blood system, kidney, nervous system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (blood system, kidney, nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In the study in which beagle dogs were fed a diet containing the substance for 90 days, effects on bone marrow and nephrosis were observed at the administration dose of 71.3mg/kg bw or higher (HSDB, 2005, IUCLID, 2000). In addition, the section of DFGOT vol.17 (2002), "Lead and its inorganic compounds", describes the kidney, blood pressure, thyroid gland, and nervous system, and the section on threshold values provides the following summary: "The most sensitive parameter of the toxic effects of lead in both men and women is the reduction in performance in neurobehavioral test systems. Other toxic effects of lead?especially effects on the peripheral nervous system and the kidneys, and the inhibition of haem synthesis?reach relevant levels only at much higher concentrations. Therefore, a threshold concentration for occupational exposure to lead must be derived from the NOAEL (no observed adverse effect level) for effects on the central nervous system." Based on these descriptions, the substance was classified into Category 1 (blood system, kidney, and nervous system).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.