GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：lead acetate, basic; lead acetate
CAS：1335-32-6
Result：
| ID: | 20A2061 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2008 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （Sep, 2008） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solid | Not classified | - | - | - | - | Nonflammable (NAERG, 2004) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Nonflammable (NAERG, 2004) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Nonflammable (NAERG, 2004) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Its water solubility is 6.25g/100ml (Ullmanns (2003)). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | No data available. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances with a melting point > 55degC are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | Data on this substance was not found. Regarding its health hazards, it is preferable to refer to those of inorganic lead such as lead acetate (CAS 301-04-2: ID 47). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | According to DFGOT vol.17 (2002), there is no data available for the local effects of lead or inorganic lead compounds on skin and mucous membranes. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | According to DFGOT vol.17 (2002), there is no data available for the local effects of lead or inorganic lead compounds on skin and mucous membranes. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Category 2 |
|
Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Data on this substance was not found. However, according to documents of IARC 23 (1980), NTP DB (accessed in Feb 2006), and DFGOT vol.17 (2002) on lead acetate (CAS 301-04-2: ID 47), the following have been reported: negative results from heritable mutagenicity tests, in vivo mutagenicity tests using germ cells not conducted, positive results from in vivo mutagenicity tests using somatic cells (chromosomal aberration tests), and in vivo genotoxicity tests using germ cells not conducted. Based on these documents, the substance was classified into Category 2. |
| 6 | Carcinogenicity | Category 1B |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
According to the IARC, inorganic lead is classified into 2A and organolead is classified into Group 3 (IARC 87 (2006)). Although basic lead acetate is not classified as a simple substance, sufficient evidence has been gained from animal tests that the substance is carcinogenic (IARC 87 (2006)). In fact, high rates of kidney tumor development have been documented from several, long-term oral route exposure tests using mice and rats (IARC 87 (2006)). In addition, the substance is classified into Category 3 in the EU classification (EU-Annex 1 (accessed July 2008)). Taking IARC's classification and evaluation of lead compounds into account, the substance was classified into Category 1B. |
| 7 | Reproductive toxicity | Category 1 |
|
Danger | H360: May damage fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Data on this substance was not found. However, inorganic lead compounds are known to possess developmental neurotoxicity and reproductive toxicity. Based on expert judgement, the substance was classified into Category 1. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (kidney, digestive system, cranial nervous system) |
|
Danger | H370: Causes damage to organs (kidney, digestive system, cranial nervous system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
The classification of this substance was done by reviewing the effects of inorganic lead compounds. In persons whose blood lead level was above 1250 or 1500microg/L after acute lead poisoning, functional disorders of the epithelium of the proximal renal tubules were detected (DFGOT 17 (2002)). In 31 patients with lead poisoning (blood lead levels 400 to 1750microg/L), on the other hand, no clinical signs of kidney damage were seen. (DFGOT vol.17 (2002)). Colic pain is an early symptom of acute poisoning with high concentrations of lead, which often involves symptoms such as abdominal pain, constipation, cramps, nausea, vomiting, anorexia, and weight loss. Exposure to high lead concentrations, that cause severe gastrointestinal dysfunction, may also cause encephalopathy (ATSDR, 2007). Based on the information, the substance was classified into Category 1 (kidney, digestive system, and cranial nervous system). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood system, kidney, nervous system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (blood system, kidney, nervous system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
The classification of this substance was done by reviewing the effects of inorganic lead compounds. The section of DFGOT vol.17 (2002), "Lead and its inorganic compounds", describes the kidney, blood pressure, thyroid gland, and nervous system, and the section on threshold values provides the following summary: "The most sensitive parameter of the toxic effects of lead in both men and women is the reduction in performance in neurobehavioral test systems. Other toxic effects of lead?especially effects on the peripheral nervous system and the kidneys, and the inhibition of haem synthesis?reach relevant levels only at much higher concentrations. Therefore, a threshold concentration for occupational exposure to lead must be derived from the NOAEL (no observed adverse effect level) for effects on the central nervous system." Based on these descriptions, the substance was classified into Category 1 (blood system, kidney, and nervous system). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |