GHS Classification Result

Chemical Name:2-hydroxyethyl methacrylate
CAS:868-77-9

Result:
ID: 20A2058
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Since its flash point is 97degC (c.c.) (HSDB, 2002), which is above 93degC, the substance is not flammable liquid.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - The substance contains an acrylic group in the form of an unsaturated bond. Since no test results were available, classification is not possible.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - The rat LD50 values documented are 8700, 5564, 5050, 11200, and > 4000mg/kg bw. Of these values, 5564mg/kg bw, which was obtained in the tests complied with FDA protocol, was used as the basis to classify the substance into "Not classified".
1 Acute toxicity (Dermal) Not classified - - - - Based on the rabbit LD50 values, 3000mg/kg bw (DFGOT, 1999) and > 3000mg/kg bw (SIDS, (accessed July 2008)), the substance was classified into "Not classified" using JIS classification criteria (Category 5 in the United Nations classification).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - Since Draize tests using rabbits resulted in the primary skin irritation index of 0.08 out of 8 maximum (24h) (SIDS, (accessed July 2008)), the substance was classified into "Not classified".
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
In rabbits, the substance was highly irritating, and caused corneal ulceration, which disappeared 15 days after the application (SIDS, accessed in July 7, 2008). Based on this result, the substance was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
4 cases of positive results were obtained from patch tests in humans (SIDS, (accessed July 2008)). Similarly, in guinea pig maximization tests using adjuvant (OECD guidelines 406, non-GLP tests), 7 out of 15 animals showed positive reactions and the substance was evaluated to be sensitizing. Thus, the substance was classified into Category 1. Among other tests, there are 20 human cases of positive reactions including "invalid" evaluations (SIDS, accessed July 2008).
5 Germ cell mutagenicity Not classified - - - - Based on negative results obtained from in vivo mutagenicity tests (micronucleus tests) (SIDS, accessed July 2008), the substance was classified into "Not classified". Among in vitro tests documented, negative results have been reported in Ames tests (SIDS (accessed July 2008)) and chromosomal aberration tests using cultured cells of Chinese hamsters (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council) (accessed July 2008)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In combined repeated oral dose toxicity study with reproduction/developmental toxicity tests using rats, no effects on fertility and the development of offspring were observed (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council) (accessed in July 2008)). However, since sufficient data on teratogenic effects was not provided, the substance was classified into "Classification not possible".
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In combined repeated oral dose toxicity study with reproduction/developmental toxicity tests using rats, slight elevation of urea nitrogen was detected in male rats at 30mg/kg or above in blood biochemistry tests. In addition, absolute weight of the kidney increased in female rats at 100mg/kg or above (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council) (accessed in July 2008)). However, since these changes observed were insignificant and thus the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Its 72h-ErC50 = 710mg/L for algae (Pseudokirchn eriella subcapitata), its 48h-EC50 = 380mg/L for crustaceans (Daphnia magna), and its 96h-LC50 is > 100mg/L for fish (medaka) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1996). Based on these results, the substance was classified into "Not classified".
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since its classification for acute toxicity is "Not classified", and it is water soluble (water solubility = 1000000mg/L (PHYSPROP database, 2008)), the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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