GHS Classification Result

Chemical Name：2-hydroxyethyl acrylate
CAS：818-61-1

Result：
ID: 20A2057
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Its flash point is 101degC (HSDB (2003)), which is higher than 93degC.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - The substance contains an acrylic group in the form of an unsaturated bond. Since no test results are available, classification is not possible.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 370degC (GESTIS (accessed July 2008)), which is higher than 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Since all documented rat LD50 values (540, 650, 540, 610, and 1070mg/kg) (SIDS (accessed July 2008)) fell within the range of 300-2000mg/kg, the substance was classified into Category 4.
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Among the rat and rabbit LD50 values documented (SIDS (accessed in July 2008)), lower rabbit values were used for evaluation. Of four LD50 values documented (154, 154, 250, and 298mg/kg), 2 values were equivalent to Category 2 and the other 2 values were equivalent to Category 3. Thus, the substance was classified into Category 2.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		In 4-hour exposure tests using rats, 1 out of 6 treated rats died at 1.87mg/L, and 5 out of 6 treated rats died at 2.37mg/L (SIDS (accessed in July 2008)). Based on these outcomes, its rat LC50 (4 hours) is estimated to be 1.87-2.37mg/L, with these values equivalent to the Category 4 guidance values. Given that its saturated vapour concentration is 69.3 ppm (0.329mg/L), the tests were presumably conducted in mist states. By exposing rats for 7 hours, it was reported that LC0 = 1.25mg/L (4-hour correction: 2.19mg/L) and LC100 = 10.58mg/L (4-hour correction: 18.52mg/L) (SIDS (accessed in July 2008)).
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		After the undiluted substance was applied to normal or damaged rabbit skins for 24 hours, extensive necrosis (epidermis), subcutaneous bleeding, and pitting edemas were observed (SIDS (accessed July 2008)). Necrosis was observed in several 24-hour application tests, concluding that the substance was highly irritating (SIDS (accessed July 2008)). However, in 4-hour application tests, the substance was concluded to be moderately irritating and not corrosive based on observations of moderate erythema and severe edemas, and necrosis of epidermis in 2 out of 6 treated rabbits (SIDS (accessed July 2008)). Based on the latter test results, the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		After the undiluted substance was applied to the eyes of rabbits, the substance was concluded to be highly irritating, with observations of bulla, corrosion and/or ulceration, severe corneal necrosis, and blepharitis (SIDS (accessed July 2008)). In other rabbit tests, extensive conjunctivitis and corneal clouding were observed, concluding that the substance was highly irritating and may cause severe injury (Grade 5 on a scale of 1-10). These symptoms continued for 7 days after the application, suggesting possible permanent visual impairment (SIDS (accessed July 2008)). From these results that indicate its irreversible effects on the eyes, the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Positive results were obtained from all of the several tests documented: maximization tests using guinea pigs, skin sensitization tests using Buehler tests, and mouse local lymph node assays (SIDS (accessed July 2008)). Furthermore, according to epidemiological studies and case reports, there have been many cases of positive reactions documented in humans who were previously exposed to acrylic compounds containing this substance and subsequently took patch tests (SIDS (accessed July 2008)). Based on these data and reports, the substance was classified into Category 1.
5 Germ cell mutagenicity Not classified - - - - Negative results were obtained from both in vivo mutagenicity tests using somatic cells (micronucleus tests using the bone marrow cells of rats that underwent oral administration, and chromosomal aberration tests using the bone marrow cells of rats that underwent inhalation exposure) (SIDS accessed July 2008)). Based on these results, the substance was classified into "Not classified".
6 Carcinogenicity Not classified - - - - No evidence of carcinogenicity was obtained in 18-month inhalation tests using rats (SIDS (accessed in July 2008)). Similarly, no evidence of carcinogenicity was found in 2-year oral route exposure tests using mice, in which incidences of tumors did not increase in treated mice (results from Carcinogenicity Studies (Ministry of Health, Labour and Welfare) (2005)), However, in rats that underwent oral exposure for 2 years, basophilic micro foci increased in treated male rats, in the form of hepatocyte adenoma and preblastomatous lesions, which were considered to be a suggestive evidence of carcinogenic effects (Results from Carcinogenicity Studies(Ministry of Health, Labour and Welfare)(2005)). Since rat oral tests yielded unclear conclusions, and rat inhalation tests and mouse oral test resulted negative, the substance was classified into "Not classified".
7 Reproductive toxicity Classification not possible - - - - Exposure to pregnant rats that underwent inhalation exposure during the organogenetic period showed toxicity to maternal animals, but no effects on the development of offspring (SIDS (accessed July 2008)). Since no data was available on the effects of the substance on the reproductive functions and fertility of parental animals that were exposed prior to mating, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects, Respiratory tract irritation） Warning H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In acute toxicity tests using rats that underwent oral administration, lowered levels of activity were observed as general symptoms at all doses tested. And in other tests, loss of righting reflexes were documented (SIDS (accessed in July 2008)). In addition, lethargy was observed at all doses tested in acute toxicity tests using rabbits that underwent dermal administration (SIDS (accessed in July 2008)). Based on these results, the substance was classified into Category 3 (narcotic effects). In terms of respiratory irritation, exposing rats via inhalation for 8 hours under saturated vapour pressure did not cause mortality, but was associated with dyspnea and severe irritation of the mucous membranes (SIDS (accessed in July 2008)). Also, inhalation exposure at 3 ppm caused irritation of the nasal cavities, and cases of respiratory tract irritation among plant workers have been documented (SIDS (accessed in July 2008)). Based on these documents, the substance was classified into Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In 28-day inhalation exposure (vapour) tests using rats, corneal irritation was shown at 5 ppm, and irritation of the nasal cavities (ulcerative rhinitis) and breathlessness were observed at 10 ppm (90-day conversion: 0.015mg/L). Furthermore, at 25 ppm (90-day conversion: 0.037mg/L), severe respiratory distress were observed. Thereafter, the animals exhibited drastic loss of body weight and died of respiratory failure.(SIDS (accessed in July 2008)). These studies indicated that exposure to the substance affects the respiratory system and eyes. Doses that induced symptoms were 10-25 ppm (90-day conversion: 0.015-0.037mg/L), which are equivalent to Category 1 guidance values. Thus, the substance was classified into Category 1 (respiratory system). 97-day oral exposure tests using dogs and 100-day oral exposure tests using rats both yielded negative results (SIDS (accessed in July 2008)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its 48h-EC50 = 5.2mg/L for crustaceans (Daphnia magna) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1998), the substance was classified into Category 2.
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since its classification for acute toxicity is Category 2, it is rapidly degradable (28-day BOD degradability = 78% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1991)), and its potential for bioconcentration is estimated to be low (LogPow = -0.21 (PHYSPROP database, 2008)), the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information