GHS Classification Result

Chemical Name：1,3-dichlorbenzene
CAS：541-73-1

Result：
ID: 20A2056
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Its flash point (63-72degC) is between 60 and 93degC.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point (640degC) is higher than 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing chlorine (but not oxygen or fluorine), which is bonded only to carbon.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		The rat LD50 values documented are 580 and 1200mg/kg for males, and 1000 and 2300mg/kg for females (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (vol.6), 2008). Based on the lower male LD50 values, the substance was classified into Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - Besides the rat LD50 of > 2000mg/kg (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (vol.6), 2008), no other data is documented. Thus, classification is not possible due to insufficient data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Its rat LC50 values documented are > 17.6mg/L and 10.8mg/L (10.8mg/L = 1793 ppm) (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (vol.6), 2008). Based on the lower LC50 value of two, the substance was classified into Category 3. Since its rat LC50 of 10.8mg/L (4-hour conversion value) is lower than its saturated vapour pressure concentration of 2832 ppm or 17.0mg/L, the test was conducted presumably in a vaporous state.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		The patch tests applied to the skin of rabbits for 24 hours resulted in that the substance caused marked irritation (DFGOT vol.1 (1991)). Based on this result, the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		The tests using rabbits resulted in mild to marked chemosis and slight clouding of the cornea (DFGOT vol.1 (1991), IUCLID (2000), BUA No.8 (1987). Based on these results, the substance was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Not classified - - - - Based on negative results (BUA report (1994)) obtained from chromosomal aberration tests using the bone marrow cells of Chinese hamsters that underwent oral administration (OECD test guidelines, GLP-compliant), the substance was classified into "Not classified". Although positive results were obtained from micronucleus tests using the bone marrow cells of mice that underwent intraperitoneal administration (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (vol.6) (accessed on May 2008)), the results were considered to be insignificant. In vitro mutagenicity tests using microorganisms yielded negative results.
6 Carcinogenicity Not classified - - - - There is no data on carcinogenicity of meta isomers in humans and other animals. Based on its placement into Group 3 by IARC, the substance was classified into "Not classified".
7 Reproductive toxicity Classification not possible - - - - No adverse effects of the substance on the development of offspring, such as embryotoxicity and teratogenic potential, were observed in pregnant rats that underwent oral exposure during the organogenetic period (DFGOT vol.1 (1991), Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (vol.6) (2008)). However, due to insufficient data on the reproductive functions and fertility of parental animals that were exposed prior to mating, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 1 (liver) Danger H370: Causes damage to organs (liver) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In single administration tests in which mice were orally administered at 300mg/kg, signs of liver damage were observed in the form of significant increase in liver weight and serum ALT, and extensive hepatocyte necrosis (IARC vol.73 (1999)). Based on these results, the substance was classified into Category 1 (liver). All animals exposed to a saturated vapour (>= 2000 ppm) at 20degC for 7 hours showed hyperactivity, increased respiration rate, irregular respiration, hyporeflexia, trembling, and balance disorders (DFGOT (1991)). However, due to insufficient data on the nervous system, classification was not possible.
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In rats that underwent repeated oral administrations for 90 days, the following changes in liver function were observed: increased liver weight and degradation of hepatocytes at doses >= 147mg/kg/day; increased frequencies of hepatocyte necrosis at 588mg/kg/day; and increased GOT and cholesterol at >= 9mg/kg/day (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (vol.6) (2008)). In rats that were administered for 10 days, the following were observed: slight and sporadic hepatocyte necrosis at >= 147mg/kg/day (90-day correction: 16.3mg/kg/day); and increased incidences of hepatocyte degradation at >= 368mg/kg/day (90-day correction: 40.9mg/kg/day) (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (vol.6) (2008)). In rats that were administered for 28 days, the following were observed that were indicative of hepatotoxicity: increased liver weight and enzyme inductions in the liver in dosage >= 100mg/kg/day (90-day correction: 31.1mg/kg/day); and raised serum transaminase values and hepatocellular hypertrophies in dosage of 500mg/kg/day (90-day conversion: 155.5mg/kg/day) (BUA No.133 (1994)). From these results, it is clear that doses within the range of Category 2 guidance values are linked to signs of liver damage. Thus, the substance was classified into Category 2 (liver).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since its 48-hour EC50 = 1.2mg/L for crustaceans (Daphnia magna) (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (vol.6) (2008)), the substance was classified into Category 2.
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its classification for acute toxicity is Category 2, and it is not rapidly degradable (non-biodegradable, BOD degradability: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1983)), the substance was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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