GHS Classification Result

Chemical Name:sodium carbonate
CAS:497-19-8

Result:
ID: 20A2055
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Not classified - - - - Nonflammable (IUCLID (2000)).
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Nonflammable (HSDB (2003)).
11 Self-heating substances and mixtures Not classified - - - - Nonflammable (HSDB (2003)).
12 Substances and mixtures which, in contact with water, emit flammable gases Classification not possible - - - - No data available.
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available.
15 Organic peroxides Not applicable - - - - Not organic compounds.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances with a melting point > 55degC are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - The rat LD50 values of 2800mg/kg and 4090mg/kg (SIDS (accessed July 20008)) are both classified into "Not classified" using JIS classification criteria (Category 5 in the United Nations classification).
1 Acute toxicity (Dermal) Not classified - - - - Based on the rabbit LD50 > 2000mg/kg (SIDS (accessed July 2008), the substance was classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Based on its rat LC50 of 1.2mg/L (4-hour conversion value) (SIDS (accessed July 2008)), the substance was classified into Category 4.
2 Skin corrosion/irritation Not classified - - - - In 4- and 24-hour dermal administration tests using rabbits, scores for erythema and edema were 0, indicating that the substance was not irritating (SIDS (accessed in July 2008). Similarly, in 4-hour patch tests with humans, scores for erythema and edema were 0, concluding that the substance was not irritating (SIDS (accessed in July 2008)). In the case of both rabbits and humans on which the substance was applied onto damaged skin, the primary irritation index was >= 2, indicating that the substance was slightly irritating (SIDS (accessed in July 2008), ECETOC No.66 (1995)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
The rabbit tests have yielded inconsistent results in that the substance was found to be not irritating and highly irritating (SIDS (accessed in July 2008)). In one of the tests, symptoms of the corneas, irises, and conjunctivas (redness and chemosis) developed in all of the cases in which the eyes were not washed after the application. These symptoms remained unrecoverable 14 days after the application, and were quantified by the maximum mean total Draize score (MMTS) of 105. Yet, in another rabbit test in which the eyes were not washed after the application, severe cases of corneal clouding were observed 1 hour after the exposure and these symptoms continued for 7 days. The average Draize scores were 3.8 for corneas and 2 for irises, and corneal pannus and keratoconus occurred in some of the treated animals. These results revealed that the substance caused serious and irreversible eye damage, and thus it was classified into Category 1. Its pH = 11.58 (5 wt% aqueous sol. at 25degC) (HSDB (2003)).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Insufficient data available.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In oral administration tests using rats, mice and rabbits during the organogenetic period, no toxic effects were found on maternal animals and the development of offspring including teratogenicity (SIDS (accessed in July 2008)). However, since there was no data on the reproductive functions and fertility of parental animals, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation, Narcotic effects) Warning H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects)
H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects)
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the tests using rats, mice, and guinea pigs, symptoms of respiratory disorder such as dyspnoea and wheezing were observed immediately after the inhalation exposure and they disappeared after 3-4 hours (SIDS (accessed in July 2008)). Based on these results, the substance was classified into Category 3 (respiratory tract irritation). In oral administrations to rats, symptoms such as motor ataxia, prostration, and lethargy were observed, and they disappeared 5 days after the administration among surviving rats (SIDS (accessed in July 2008)). In dermal administrations, although lethargy was observed 24 hours after the administration, no mortality occurred (SIDS (accessed in July 2008)). Since these symptoms observed were recoverable, the substance was classified into Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the tests in which rats underwent inhalation exposure at 70mg/m3/4h (0.0467mg/L/6h) for 3.5-months, localized effects such as hyperplasia and desquamation of bronchial epithelium, and perivascular oedema were observed (SIDS (accessed in July 2008)). However, these symptoms are not considered to be severe toxic effects. In addition, these tests were conducted using only male rats and one dose, and lack other information. As such, classification is not possible.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Since its 48 h-EC50 = 250mg/L for crustaceans (Daphnia magna) (SIDS 2002), the substance was classified into "Not classified".
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - It is water soluble (water solubility = 5307mg/L, PHYSPROP database 2008) and as its classification for acute toxicity is "Not classified", the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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