Chemical Name：2-[2-(2-butoxyethoxy)ethoxy]ethanol; TEGBE; triethylene glycol monobutyl ether; butoxytriethylene glycol
CAS：143-22-6

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on the rat LD50 obtained from List 1 source (5300mg/kg, 6660mg/kg, and 5170mg/kg) (accessed July 2008), DFGOT (vol.9 2007)), the substance was classified into "Not classified".
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Since the rabbit LD50 = 3540mg/kg (SIDS (accessed July 2008)), the substance was classified into "Not classified" using JIS classification criteria (Category 5 in the United Nations classification).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Not classified	-	-	-	-	Based on its rat LCLo > 200mg/L/1H, which is equivalent to 50mg/L/4H (SIDS (accessed July 2008)), the substance was classified into "Not classified".
2	Skin corrosion/irritation	Not classified	-	-	-	-	In several 24-hour skin irritation tests using rabbits, various conclusions were drawn: the substance was not, slightly, or moderately irritating (SIDS (accessed in July 2008)). In some of the tests that concluded that the substance was moderately irritating, congestion of blood in the capillary was noted, but the irritation score was only Grade 3 (Given that grades were calculated with10 as the maximum rating, not 8, Grade 3 generally represents a severe case of capillary congestion), which suggested no development of erythema or edema. In addition, 24-hour administration may have contributed to stronger reactions than shorter-term tests. Overall, taking negative results into account, the substance was classified into "Not classified".
3	Serious eye damage/eye irritation	Category 2A		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	After applications of the substance into the eyes of rabbits, redness and swelling of the conjunctivas were observed at every observation time and in all treated animals, and the total testing score was 21 (out of 110 maximum) (SIDS (accessed July 2008)). In addition, a different test, in which various concentrations of the substance were applied, resulted in that the substance was highly irritating and was scored 5 (out of 10 maximum) (SIDS (accessed July 2008)). Based on these results, the substance was classified into Category 2A.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Negative results were obtained from in vitro mutagenicity tests (Ames tests) (SIDS (accessed July 2008), DFGOT vol.9)), but since there was no in vivo test data available, the substance was classified into "Classification not possible".
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available.
7	Reproductive toxicity	Classification not possible	-	-	-	-	In oral route exposure tests using rats during the organogenetic period, no effects were detected on the development of offspring (SIDS (accessed July 2008)). However, the tests did not provide any data on the reproductive functions and fertility of parental animals. As such, classification is not possible.
8	Specific target organ toxicity - Single exposure	Not classified (oral, dermal, inhalation)	-	-	-	-	In the oral route, dermal route, and inhalation (mist) tests conducted, no effects were observed at administration doses (3200mg/kg for oral, 2000mg/kg for dermal, and 200mg/L for inhalation) that were higher than the upper limit of Category 2 guidance values (SIDS (accessed July 2008)). Therefore, the substance was classified into "Not classified" (oral, dermal, inhalation).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	A 21-day dermal administration test using rabbits is the only repeated exposure test documented on this substance; no toxic effects were found (SIDS (accessed July 2008)). However, this test alone with only one dose administered (1000mg/kg/day) does not provide sufficient information for the evaluation of systemic toxicity. Thus, classification is not possible.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.