GHS Classification Result

Chemical Name:3,6-diazaoctanethylenediamin; triethylenetetramine
CAS:112-24-3

Result:
ID: 20A2046
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Since its flash points documented are 143degC (Merck, 14th (2006)), 135degC (Chapman (2008)), 129degC (Hommel (1996)), all of which are >= 110degC, the substance was classified into "Not classified".
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Since its autoignition points documented are 338degC (Sax, 11th (2004)) and 335degC (Hommel (1996)), both of which are higher than 70degC, the substance was classified into "Not classified".
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Not classified - - - - It is classified into Class 8 (corrosives) according to the United Nations Recommendations on the Transport of Dangerous Goods. However, its packing instruction code is IBC02, in which steel, aluminum and metal are designated as container materials. Based on this information, the substance was classified into "Not classified".

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on the rat LD50 values of 2500, 2780, 3750 (SIDS (1998)), and 4340mg/kg (PATTY, 5th (2001), SIDS (1998)), the substance was classified into "Not classified" in accordance with JIS classification criteria (Category 5 in the United Nations classification).
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rabbit LD50 of 550mg/kg (SIDS (1998)) and 805mg/kg (PATTY, 5th (2001), SIDS (1998)), the substance was classified into Category 3.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
In rabbit skin tests, the substance caused not only erythema and edema, but also necrosis in several tests (SIDS (1998)). Thus, the substance was classified into Category 1.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
Rabbit eye tests resulted in severe corneal damage (SIDS (1998)). Furthermore, some data indicate its dermal corrosiveness (SIDS (1998)). Thus, the substance was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - Insufficient data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
In skin sensitization tests using guinea pigs (maximizing tests), 80% and 90% of treated animals showed positive reactions, concluding that the substance was sensitizing (SIDS (1998)). Positive results have been also obtained from auricular edema tests against mice (SIDS (1998)). In human cases and epidemiological studies, many reports indicate that the substance is skin sensitizing (SIDS (1998)). Based on these positive skin sensitization cases documented in animals and humans, the substance was classified into Category 1.
5 Germ cell mutagenicity Not classified - - - - Based on negative results obtained from micronucleus tests using mice that underwent intraperitoneal administration (in vivo mutagenicity tests using somatic cells) (SIDS (1998)), the substance was classified into "Not classified". Among in vitro mutagenicity tests, positive results were represented by several indicators such as reverse mutation using bacteria and chromosomal aberration tests using cultured mammalian cells (SIDS (1998)).
6 Carcinogenicity Classification not possible - - - - 2-year or life-long administration of the substance onto mouse skin resulted in no development of skin tumors, and no increase in frequencies of tumorigenesis in other body parts (SIDS (1998)). However, documented data include only dermal tests and male mice. Thus, classification is not possible due to insufficient data available.
7 Reproductive toxicity Classification not possible - - - - In both oral administration tests using rats, and dermal administration tests using rabbits during gestational periods including organogenetic periods, no adverse effects were observed on development of the offspring including fetuses and teratogenicity (SIDS (1998)). However, classification is not possible due to insufficient data available on effects on reproductive functions and fertility of parents. As additional relevant notes, although abnormality in treated rat fetuses occurred at significantly higher frequencies, this was thought to be secondary effects of copper deficiency caused by chelation (SIDS (1998)).
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
Reversible, slight inflammation of mucous membranes and inhibition of respiration were observed in mice, rats, rabbits, and guinea pigs (SIDS (1998)). In addition, exposure to aerosol caused reversible respiratory tract irritation (SIDS (1998). Based on these documents, the substance was classified into Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In 4-month oral administration tests using rats, excitation of the central nervous system, decreased proteins in serum, decreased hemoglobin, and decreased hippuric acid were observed at 215mg/kg (SIDS (1998)). Also, in 10-month oral administration tests using rats, increased excitability and stimulated tactile reflexes were observed at 0.8mg/kg (SIDS (1998)). In human exposure cases, increased lymphocytes and neutrophil, drowsiness, headache, gastric pain, fatigue, weakness, and decreased appetite have been documented (SIDS (1998)). Although these results from animal tests and human exposure cases suggested adverse effects on blood and the central nervous system, the substance was classified into "Classification not possible" due to insufficient data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its 48-hour EC50 = 31.1mg/L for crustaceans (Daphnia magna) (SIDS, 2004), the substance was classified into Category 3.
11 Hazardous to the aquatic environment (Long-term) Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its classification for acute toxicity is Category 3, and it is not rapidly degradable (complied with OECD302B, degradability in 28-day tests: 0% (SIDS, 2004)), the substance was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information