GHS Classification Result

Chemical Name:2-butoxyethyl acetate; butylglycol acetate
CAS:112-07-2

Result:
ID: 20A2045
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Its flash point (71degC (HSDB 2002)) is between 60degC and 93degC.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 340degC (HSDB (2002)), which is >= 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - It contains oxygen (but not fluorine or chlorine), with oxygen chemically bonded only to carbon.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - 4 out of 5 rat LD50 values documented (3000 (males), 2400 (females), 1600, 7000, and 2360mg/kg bw) (SIDS (accessed June 2008)) are equivalent to the "Not classified" category of JIS classification (Category 5 in GHS classification).
1 Acute toxicity (Dermal) Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Since the rabbit LD50 = 1500mg/kg (SIDS (accessed June 2008)), the substance was classified into Category 4.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Although the rat LC50 of > 400ppm (4 hours) (SIDS (accessed June 2008)) was documented, classification is not possible due to insufficient data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - In Draize tests using rabbits, the substance was found to be moderately irritating after 24 hours of exposure (ATSDR (1998)). In other tests, only slight irritation was observed in 4 out of 6 animals, which reflected the primary skin irritation index value of 0.17 (SIDS (accessed June 2008)). Furthermore, in 4-hour exposure tests, the substance was evaluated to be not irritating, and the average score for erythema was the lowest possible value for irritants (ATSDR (1998)). From these results, the substance was classified into "Not classified" in accordance with JIS classification criteria (Category 3 in GHS classification).
3 Serious eye damage/eye irritation Not classified - - - - In Draize tests using rabbits, mild redness of the conjunctivas and discharge were observed after 24 hours, which disappeared in 48 hours. Since the substance was evaluated to be not irritating (Draize irritation score = 0.67) (SIDS (accessed June 2008)), it was classified into "Not classified".
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Negative results from skin sensitization tests (Guinea pig maximization tests) have been documented for ethylene glycol monobutyl ether, which is a hydrolyzate of ethylene glycol monobutyl ether acetate in the body (SIDS (accessed June 2008)). However, since no data were available specifically for this substance, classification is not possible.
5 Germ cell mutagenicity Classification not possible - - - - Regarding ethylene glycol monobutyl ether, negative results have been documented from both in vitro tests and in vivo mutagenicity tests (micronucleus tests using the bone marrow cells of rats and mice that underwent intraperitoneal administration) using somatic cells (SIDS (accessed June 2008)). However, since no data specifically on this substance were available, classification is not possible.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since this substance is hydrolyzed into butyl ether in the body, use of data on ethylene glycol monobutyl ether is appropriate for evaluation of ethylene glycol monobutyl ether acetate (SIDS (accessed June 2008)). In 2-year inhalation exposure tests using rats and mice that were applied with ethylene glycol monobutyl ether, frequencies of developing both benign and malignant pheochlromocytoma in adrenal medulla increased in female rats, making the results ambiguous. However, in mice, occurrences of angiosarcoma in livers increased in males, and occurrences of squamous papilloma or squamous cell carcinoma increased in females, providing evidence of carcinogenicity (SIDS (accessed June 2008)). Based on these results and the fact that this substance has been classified into A3 by ACGIH (2003), the substance was classified into Category 2.
7 Reproductive toxicity Classification not possible - - - - Ethylene glycol monobutyl ether, a byproduct resulted from hydrolysis of ethylene glycol monobutyl ether acetate in the body, was applied to 2 generations of mice that underwent oral route exposure in reproductive tests. In these tests, surviving offspring numbers decreased due to the treatment (SIDS (accessed June 2008)). In oral route or inhalation exposure tests using rats, rabbits, or mice that were exposed to the substance during the organogenetic period, decreased numbers of surviving implantation and fetuses, increased numbers of non living implantation and resorption of embryos, and loss of implanted embryos were observed at doses that trigger maternal toxicity (SIDS (accessed June 2008), ATSDR (1998)). However, since no direct data on this very substance were available, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 2 (erythrocyte, kidney) Warning H371: May cause damage to organs (erythrocyte, kidney) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
In dermal acute toxicity tests using rats (LD50 = 1500mg/kg: equivalent to Category 2), the following are documented: hemoglobinuria, bloody urine, decreased erythrocytes / hemoglobin, and necrosis of renal tubules accompanied with glomerular lesion of kidneys. In oral acute toxicity tests (LD50 = 2400-3300mg/kg: equivalent to "Not classified"), hemoglobinuria, bloody urine, nephrosis, expansion of renal tubules, necrosis of renal tubules, and degeneration of hyaline droplets were observed. In addition, hemoglobinuria and bloody urine have been also observed by inhalation exposure at 400ppm (2.6mg/L: equivalent to Category 2), although they were less severe. Based on toxic symptoms observed with oral and dermal administrations, erythrocytes and kidneys were considered as target organs; and the LD50 values for these organs indicated that these symptoms occurred at the doses in the range of Category 2 guidance values or higher. Thus, the substance was classified into Category 2 (erythrocyte, kidney).
9 Specific target organ toxicity - Repeated exposure Category 2 (hematopoietic system) Warning H373: May cause damage to organs through prolonged or repeated exposure (hematopoietic system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In 30-day inhalation tests using rats (4-hour exposure), mortality, hemoglobinuria, hematuria, decreased numbers of erythrocytes and hemoglobin, hypertrophy of the kidneys, and nephrosis were observed at 400 ppm/4h (90-day, 6-hour correction: ca.0.71mg/L/6h). In addition, 4-week inhalation exposure tests using rats, rabbits, or cats (6-hour exposure), characteristics of anemia, such as decreased hemoglobin, hematocrit, and erythrocytes, were observed at 2.3mg/L (90-day equivalent: ca. 0.71mg/L), which is the dose equivalent to Category 2 guidance values (SIDS (accessed in June 2008)). Thus, the substance was classified into Category 2 (hematopoietic system). As relevant notes, ethylene glycol monobutyl ether, a byproduct resulted from hydrolysis of ethylene glycol monobutyl ether acetate in the body, was also studied. Applying this byproduct at 62.5-125 ppm (Category 2 equivalent) or above to rats and mice in 14-week inhalation exposure tests, hemolytic anemia was shown in both animals, and signs of anemia were observed in the liver, kidney, bone marrow, and spleen (SIDS (accessed in June 2008)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its 48h-EC50 = 67.5mg/L (EU-RAR, 2006) for crustaceans (Daphnia magna), the substance was classified into Category 3.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Its classification for acute toxicity is Category 3, it is rapidly degradable (6.5-day DOC degradability > 90% (EU-RAR, 2006), and its potential for bioconcentration is estimated to be low (bioconcentration factor for fish (estimate) = 3.8 (EU-RAR, 2006)). Based on this information, the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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