GHS Classification Result

Chemical Name:2,2'-thiodiethanol; thiodiglycol
CAS:111-48-8

Result:
ID: 20A2043
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Its flash point is 160degC (Merck (14th, 2006), which is higher than 93degC.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 260degC (ICSC (2005)), which is higher than 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) in the molecule, with oxygen chemically bonded only to carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Since the rat LD50 values documented are all >= 5000mg/kg (SIDS (2004)), the substance was classified into "Not classified".
1 Acute toxicity (Dermal) Not classified - - - - Since the rabbit LD50 = 23600mg/kg (SIDS (2004)), the substance was classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Although the rat LCLo of > 5.4mg/L/1h = 1.4mg/L/4h (SIDS (2004)) had been documented, classification is not possible due to insufficient data.
2 Skin corrosion/irritation Not classified - - - - Skin irritation tests using rabbits (complied with OECD guideline 404) concluded that the substance was not an irritant, based on the observation of slight erythema (score 1) in 1 of 3 treated rabbits (SIDS (2004)). From these results, the substance was classified into "Not classified" (also "Not classified" in the United Nations classification).
3 Serious eye damage/eye irritation Not classified - - - - In rabbit tests (complied with OECD guidelines 405), no effects on the cornea and irises were observed. Slight redness in conjunctivas was observed in 2 out of 3 treated rabbits with the maximum average score 5.3 out of 110, concluding that the substance was not an irritant (SIDS (2004)). In other rabbit studies, the substance was evaluated to be a slight irritant. However, the only average score that met the Category 2 criteria was represented by Score 1 for corneal clouding which occurred in 1 of 2 treated rabbits, and the symptom was recoverable (SIDS (2004)). From these results, the substance was classified into "Not classified".
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - In skin sensitization tests using guinea pigs (maximization tests) (compiled with OECD guidelines 406), the substance was not sensitizing to skin by challenge (SIDS (2004)). Thus, the substance was classified into "Not classified".
5 Germ cell mutagenicity Not classified - - - - Based on negative results yielded from in vivo mutagenicity tests using somatic cells (micronucleus tests using the mouse bone marrow cells: complied with OECD guidelines 474) (SIDS (2004)), the substance was classified into "Not classified". Among in vitro mutagenicity tests, Ames tests resulted negative, and chromosomal aberration tests using CHO cells resulted positive (SIDS (2004)).
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Classification not possible - - - - In developmental toxicity tests in which pregnant rats underwent oral administration during the organogenetic period, decreased body weight in maternal animals and increased frequencies of skeletal mutation (dumbbell ossification of thoracic vertebral bodies) in some animals were observed; no adverse effects on development of the offspring such as teratogenicity were observed (SIDS (2004)). However, data are lacking in terms of the effects on reproductive functions and fertility of parental animals that were exposed to the substance prior to mating. Thus, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 3 (Respiratory tract irritation) Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since irritation to mucous membranes has been observed in inhalation tests using rats (saturated vapour) (SIDS (2004)), the substance was classified into Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In 28-day (OECD guidelines 407) and 90-day (comparable to the current OECD guidelines 408) repeated oral administration tests using rats, NOAEL were 1000mg/kg/day (90-day correction: 311mg/kg/day) and 500mg/kg/day, respectively; and common toxic effects observed were decreased body weight gain and increased kidney weight at high administration doses (>= 1000mg/kg/day) (SIDS (2004)). Similarly, in other repeated oral administration tests (2 weeks and 90 days), no serious toxicity was observed other than its effects on body weight and kidney weight at high doses (SIDS (2004)). The results of 28-day and 90-day repeated oral route exposure tests with rats, in which its NOAEL for both test durations exceeded upper limits of the Category 2 guidance values, leads to its classification into "Not classified" (oral route). However, due to lack of data on other exposure routes, the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Based on 96-hour LC50 > 10000mg/L for fish (a species of chub), 48-hour EC50 > 500mg/L for crustaceans (Daphnia magna), and 72-hour ErC50 > 500mg/L for algae (SIDS, 2006), the substance was classified into "Not classified".
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since it is water soluble (water solubility = 1000000mg/L (PHYSPROP database, 2008)) and its classification for acute toxicity is "Not classified", the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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