GHS Classification Result

Chemical Name：2-methoxy-1-methylethyl acetate
CAS：108-65-6

Result：
ID: 20A2040
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Its flash point is 42degC (NFPA (13th, 2006)), which is >= 23degC and <= 60degC.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 354degC (NFPA (13th, 2006)), which is >= 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the rat LD50 values documented (> 10000mg/kg (males), > 8532mg/kg (females), and > 13700mg/kg b.w. (males)) (SIDS (accessed June 2008)), the substance was classified into "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Based on the rabbit LD50 (> 5000mg/kg) (SIDS, accessed June 2008), the substance was classified into "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Its acute toxicity values for rats (4-hour exposure values) are: LC0 > 31.01mg/L (5737 ppm) (SIDS (accessed in June 2008)), LC0 > 9.342mg/L (1728 ppm) (DFGOT vol. 5 (1993)), LD50 > 19.82mg/L (3667 ppm) (SIDS (accessed in June 2008)). Because these values are lower than 90% of the saturated vapour pressure concentration, criterion values for gases were adopted. Since no categories were appropriate, classification is not possible.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - No detailed information is available other than descriptions that the substance was not irritating based on the primary skin irritation index of 0.0 obtained from rabbit tests (SIDS (accessed June 2008)), and that the substance caused slight irritation or cutaneous irritation (DFGOT vol. 5 (1993), PATTY (5th, 2001)). Based on JIS classification criteria, the substance was classified into "Not classified" (Category 3 in the United Nations GHS classification).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Applications into rabbit eyes resulted in moderate redness of the conjunctivas, mild conjunctival chemosis, mild iritis, and corneal clouding, with their scores 0.8, 0.5, 0.1, and 0.2, respectively. Since these symptoms disappeared 4 days after application, the substance was considered to be slightly irritating (SIDS (accessed in June 2008).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - Several tests using guinea pigs (Magnusson-Kligman maximization tests and the method of Maguire) concluded that the substance did not produce sensitization (SIDS (accessed June 2008), DFGOT vol. 5 (1993)). Based on these results, the substance was classified into "Not classified".
5 Germ cell mutagenicity Classification not possible - - - - Although in vitro mutagenicity tests (Ames tests and chromosomal aberration tests) yielded negative results (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council) (accessed June 2008)), there were no in vivo test data available. Thus, classification is not possible.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Not classified - - - - In combined repeated oral dose toxicity study with the reproduction/developmental toxicity tests using rats, body weight gain was significantly suppressed in parents of both sexes, but no significant differences from control were observed in indices that measure reproductive functions of parents, fertility, and development of the offspring (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council) (accessed in June 2008)). In addition, in oral administration tests using pregnant rats during the organogenetic period, no effects were observed on development of the offspring including teratogenicity (SIDS (accessed in June 2008)). As results suggested no adverse effects on reproductive functions, fertility, and development of the offspring including teratogenicity, the substance was classified into "Not classified".
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects, Respiratory tract irritation） Warning H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In oral administration to rats at 500-10000mg/kg, lethargy was observed at all doses tested (SIDS (accessed in June 2008), and in dermal administration to rabbits, narcotic effects were documented as main symptoms (DFGOT vol. 5 (1993)). Furthermore, in 2-week inhalation exposure tests, degeneration of olfactory epithelium in nasal cavities were observed in mice at 1.62mg/L (90-day correction: 0.25mg/L) or above as an acute change, and the degeneration worsened and expanded with increased exposure concentrations. In some of the treated animals, inflammatory exudate was observed in their lumens (SIDS (accessed in June 2008)). From these observations, the substance was classified into Category 3 (narcotic effects and respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In combined repeated oral dose toxicity study with the reproduction/developmental toxicity tests using rats, decreased body weight gain and reduced food consumption were observed at 1000mg/kg/day, however, at 300mg/kg/day or below, no effects of exposure were observed. Its NOAEL was 300mg/kg/day (90-day conversion: approx. 150mg/kg/day) for both sexes and serious toxic effects were not detected (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council) (accessed in June 2008)). On the other hand, in 2-week inhalation exposure tests, a slight increase in the eosinophilic granularity of the proximal convoluted tubules of the kidneys were detected mostly in male rats at 5.39mg/L (90-day conversion: 0.83mg/L) or above. In addition, degeneration of olfactory epithelium in nasal cavities in rats was detected at 16.18mg/L, and in mice, degradation occurred rapidly at concentrations of 1.62mg/L (90-day conversion: 0.25mg/L) or above, and it became more severe and extensive with increased exposure concentrations. In some of the treated animals, inflammatory exudate was observed in their lumens (SIDS (accessed in June 2008)), but its toxicological significance is unclear since the symptoms may be recoverable (the substance is a respiratory tract irritant by single exposure). From these results, symptoms observed in male rat kidney are mild, and histological changes in nasal cavities of rats and mice, especially of mice, were detected at concentrations within the range of Category 2 guidance values. However, since details of these tests were not provided, the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Based on its 72h-ErC50 > 1000mg/L for algae (Pseudokirchn eriella subcapitata), 48h-EC50 of 370mg/L for crustaceans (Daphnia magna), and 96h-LC50 > 100mg/L for fish (medaka) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1997), the substance was classified into "Not classified".
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since it is water soluble (water solubility > 100g/L (EU-RAR, 2006)) and its classification for acute toxicity is "Not classified", the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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