GHS Classification Result

Chemical Name:4-chlorotoluene
CAS:106-43-4

Result:
ID: 20A2034
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 3 Warning H226: Flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Since its flash point is >= 23degC and <= 60degC, the substance was classified into Category 3 according to GHS classification criteria for flammable liquids.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 595degC (Hommel, 1996).
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains chlorine (but not oxygen or fluorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on the rat LD50 values of 1900mg/kg bw (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment), vol. 6, 2008 (original literature, 1964)), 2100mg/kg bw (SIDS accessed in 2008), 2273mg/kg bw (SIDS accessed in 2008), and 2389mg/kg bw (SIDS accessed in 2008), the substance was classified into "Not classified" (Category 5 in the United Nations classification).
1 Acute toxicity (Dermal) Not classified - - - - Based on the rat LD50 of > 5000mg/kg bw (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment), vol. 6, 2008, SIDS 2005) and the rabbit LD50 of > 2000mg/kg bw (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment), vol. 6, 2008, SIDS 2005), the substance was classified into "Not classified" (Category 5 or "Not classified" in the United Nations classification).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Since its LC50 (rats) is 26900mg/m3 1hr (4-hour conversion: 13.45mg/L, Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment), vol. 6, 2008, BUA report 38, 1989)) and its saturated vapour pressure exceeds 17.9mg/L, the substance was classified into Category 4 according to the criteria for a mist.
2 Skin corrosion/irritation Not classified - - - - Rabbit studies (FDA guidelines) have documented that the substance is not an irritant (SIDS, 2005), or it is associated with slight erythema (score: 1) and is slightly irritating (SIDS, 2005). From these results, the substance was classified into "Not classified".
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Rabbit studies (FDA guidelines) concluded that the substance was slightly irritating (Score 1 for slight conjunctival redness and edemas, which disappeared within 7 days) (SIDS 2005). Similarly, Draize tests using rabbits concluded that the substance was slightly irritating (Score 2 for slight conjunctival redness and edemas, which disappeared within 14 days) (SIDS 2005). From these results, it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Based on positive results from maximization tests using guinea pigs (OECD guidelines 406, GLP-compliant) (SIDS 2005), the substance was classified into Category 1.
5 Germ cell mutagenicity Not classified - - - - Based on negative results from in vivo mutagenicity tests using somatic cells (micronucleus tests) (SIDS 2005), the substance was classified into "Not classified".
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In reproductive and developmental toxicity tests in which female rats underwent oral administration, single administrations caused embryonic toxicity, and 2-month administrations at 550mg/kg bw caused an increase in embryonic mortality rates and rates of losing pre-implantation embryos. In addition, hypertrophy of the liver in fetuses and underdevelopment of the liver were observed (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment), vol. 6, 2008). However, because no information on parental animals is available, the substance was conservatively classified into Category 1B.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No data available.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - The 29-day repeated oral administration tests using rats (OECD guidelines 407, GLP) resulted in NOAEL of 200mg/kg bw/day (90-day correction: 64mg/kg bw/day) and increased liver weight at a high dose (800mg/kg bw/day, 90-day correction: 256mg/kg bw/day). In histopathological studies, few cases of moderate inflammatory-cellular focal infiltrates in the liver and vacuoles in the hepatocytes were detected (SIDS 2005). Furthermore, in 14-day repeated oral administration tests using rats, NOAEL was 600mg/kg bw/day (90-day correction: 83mg/kg bw/day) (SIDS 2005). Based on these results, it was difficult to choose between Category 2 and "Not classified" and thus the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its 48-hour EC50 = 1.65mg/L for crustaceans (Ceriodaphnia) (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (vol. 6), 2008; SIDS, 2006), the substance was classified into Category 2.
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its classification for acute toxicity is Category 2, and it is not rapidly degradable (non-biodegradable, BOD degradability: 0% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1979)), the substance was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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