GHS Classification Result

Chemical Name:2-ethylhexyl acrylate
CAS:103-11-7

Result:
ID: 20A2033
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Since its flash point is 87degC (Ulmmanns (6th, 2003)), the substance was classified into Category 4 (flash point > 60degC and <= 93degC).
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - The substance contains an acrylic group in a form of an unsaturated bond. Since no testing results were available, classification is not possible.
9 Pyrophoric liquids Not classified - - - - Since its flash point is 252degC (Howard (1986), ICSC (2003), ICSC (J) (2003), NFPA (11th, 2004)), which is >= 70degC, the substance was classified into "Not classified".
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on the rat LD50 values of 5700mg/kg, 4430mg/kg (EU-RAR, 2005), 5660mg/kg, and 6400-12800mg/kg (PATTY (5th, 2001)), the substance was classified into "Not classified".
1 Acute toxicity (Dermal) Not classified - - - - Based on the rabbit LD50 values of > 10000mg/kg and 14180mg/kg (EU-RAR, 2005), the substance was classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Although the mouse LC 50 value of > 0.6mg/L is documented (IUCLID (2000)), the exposure period was not provided. In a different test, its LC50 was > 450mg/m3 (RTECS (2006)), but the exposure period and animal species tested were not provided. Thus, due to lack of data, the substance was classified into "Classification not possible".
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - - Although its mouse LC50 of > 7.713mg/L/30min. (4-hour conversion: > 0.964mg/L/4h) (IUCLID (2000)) was documented, classification is not possible. In other studies, in which rat TCLo was 6.2g/m3/L/6h (equivalent to 9.3g/m3/L/4h) (RTECS (2000)), no mortality occurred, which indicates that "Not classified" is the appropriate classification. Overall, the substance was classified into "Not classified" based on the rat data.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Based on average Draize test scores of erythema in rabbits: 3.2 (24 hours after the treatment) and 2.7 (72 hours after the treatment) (EU-RAR, 2005), the substance was classified into Category 2.
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
In rabbit tests, necrosis of the cornea was observed, but its recovery status was not provided (EU-RAR, 2005). Also, the substance is documented to be less irritating to the eyes than to the skin (EU-RAR, 2005). Based on these documents, the substance was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
In 2 of 4 patients with dermatitis from UV-cured lacquers, reactions to the substance were observed (DFGOT (vol. 16, 1999)). In addition, in the patch tests a patient with an allergy to polyethylene glycol dimethacrylate produced positive reactions to the substance of 0.5% concentration 72 hours after exposure (DFGOT (vol. 16, 1999)), all of the 7 male volunteers tested showed positive reactions (EU-RAR (2005)), and 14 persons tested also showed positive reactions (EU-RAR (2005)). Furthermore, in guinea pig maximization tests using adjuvant, 11 out of 19 animals treated with 3% concentration showed positive reactions. Based on these results, the substance was classified into Category 1.
5 Germ cell mutagenicity Classification not possible - - - - In micronucleus tests using the cultured mouse bone marrow cells, no clear results were obtained (EU-RAR, 2005). Among in vitro tests, negative results were observed from Ames tests and unscheduled DNA synthesis tests; and weak positive reactions were obtained from mouse lymphoma tests, HPRT tests using CHO cells, and sister chromatid exchange tests using rat hepatocytes: no sturdy positive reactions were noted in these tests. Therefore, the substance was classified into "Classification not possible".
6 Carcinogenicity Classification not possible - - - - In dermal application tests using mice (males: C3H/HeJ), incidences of mammary adenoma, squamous cell carcinoma, and malignant melanoma increased in intermediate to high dose groups; incidences of basal cell carcinoma increased in intermediate dose groups; and incidences of hemangioma increased in high dose groups. In dermal application tests using mice (males: NMRI), increased incidences of tumors were not noted (EU-RAR, 2005). Although these positive results were obtained, the IARC rated the substance as Group 3, (HSDB (2004)), and there is a discription that results from dermal tests with mice do not provide evidence that the substance is carcinogenic (SIDS (J), accessed in October 2008)). Consequently, the substance was classified into "Classification not possible".
7 Reproductive toxicity Classification not possible - - - - In inhalation tests using rats, no effects on reproductive organs in both sexes, embryos, teratogenicity, and the offspring were observed (EU-RAR, 2005). However, since information on reproductive functions was lacking, the substance was classified into "Classification not possible".
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects) Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
In oral administration tests using rats (administration doses unknown) (EU-RAR (2005)), apathy, a narcotic state, and diarrhea were observed. In oral administration tests using mice (2500 and 5000mg/kg) (EU-RAR, 2005), decreased spontaneous motor activity, ataxia, and abdominal breathing were observed. Since inactivity and motor ataxia, etc, were observed, the substance was classified into Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Category 2 (Inhalation: nasal cavity) Warning H373: May cause damage to organs through prolonged or repeated exposure (Inhalation: nasal cavity) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In 90-day inhalation tests using rats (vapor), degeneration of olfactory epithelium of the nasal cavity was observed (EU-RAR, 2005). Thus, the substance was classified into Category 2 (nasal cavity (inhalation)).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its 48h-EC50 = 1.3mg/L for crustaceans (Daphnia magna) (EU-RAR, 2005), the substance was classified into Category 2.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Its classification for acute toxicity is Category 2, it is rapidly degradable (degradability in 28 days based on OECD TG301F = 75% (EU-RAR, 2005)), and its potential for bioconcentration is estimated to be low (logKow = 3.9 (EU-RAR, 2005)). From this information, the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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