GHS Classification Result

Chemical Name:N-isopropyl-N'-phenyl-p-phenylenediamine
CAS:101-72-4

Result:
ID: 20A2031
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (Si, Ge, As, Sb, Bi, etc.).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - The substance does not contain oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable - - - - The substance does not contain a peroxide-related atomic group (O-O).
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the rat LD50 values of 522mg/kg for males and 701mg/kg (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), 2003) plus 900mg/kg for females (SIDS, 2000), the substance was classified into Category 4.
1 Acute toxicity (Dermal) Not classified - - - - Since no mortality occurred in rabbits administered at 5010 and 7940mg/kg (SIDS, 2000), the substance was classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - Old documents indicate that the substance is not irritating to slightly irritating to humans without providing definite conclusions (SIDS (2000)). Furthermore, in rabbit studies, the substance was determined to be slightly irritating, since 1 out of 3 treated rabbits showed signs of irritation 12 hours after the treatment, but they disappeared within 24 hours (IUCLID (2000)). Based on these test results in humans and rabbits , the substance is indicated to be "no irritating" in the SIDS. Thus, the substance was classified into "Not classified".
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
In rabbit tests, the following was documented: mild erythema was seen in the conjunctivas 24 hours after application, but they disappeared in 48 hours (SIDS, 2000); moderate irritation was observed 24 hours after application (SIDS, 2000); the results ranged from not irritating to slight irritating (IUCLID, 2000); and mechanical irritation was seen in 2 out of 3 rabbits treated (IUCLID, 2000). Based on these descriptions, the substance was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
In skin sensitization tests using guinea pigs, reactions were observed in 70% of the animals (SIDS, 2000), thus, the substance was classified into Category 1.
5 Germ cell mutagenicity Classification not possible - - - - No test results using germ cells are not available. In vivo genotoxicity tests (SCE) yielded negative results (BUA 207, 1996, IUCLID 2000) while in vitro mutagenicity tests (chromosomal aberration tests) (SIDS 2000) and in vitro genotoxicity assays (SCE) (SIDS 2000) both gave positive results. Based on these results, the substance was classified into "Classification not possible".
6 Carcinogenicity Classification not possible - - - - Since no data on humans and animals are available, the substance was classified into "Classification not possible".
7 Reproductive toxicity Classification not possible - - - - No sufficient data available for classification.
8 Specific target organ toxicity - Single exposure Category 2 (liver, kidney, blood system) Warning H371: May cause damage to organs (liver, kidney, blood system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
In oral route tests using rats, toxic symptoms were observed in the liver (centrilobular hepatocytes hypertrophy, increased mitotic figures of hepatocytes, and extramedullary hematopoiesis of the liver), kidney (regeneration of urinary tubules and infiltration of lymphocytes in kidney medulla), and spleen (excessive extramedullary hematopoiesis) at 455mg/kg bw or above (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), 2003). Therefore, the substance was classified into Category 2 (liver, kidney, blood system).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, blood system) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In 28-day repeated oral administration tests using rats, toxic symptoms were observed in the blood (decreased erythrocytes, hemoglobins, and hematocrit values), liver (swelling, hypertrophy of acidophilic hepatocytes, fatty degeneration of the intermediate zone of the lobule, and necrosis of single cells), and spleen (swelling, hemosiderin deposition, and reinforced increase of extramedullary hematopoiesis) at 100mg/kg bw (90-day conversion: 31mg/kg bw) or above (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council), 2003). Therefore, the substance was classified into Category 2 (liver, blood system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its 96-hour EC50 = 0.34mg/L for fish (rainbow trout) (SIDS, 2000), the substance was classified into Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since its acute toxicity is Category 1 and it is not rapidly degradable (non-biodegradable, BOD degradability: 2.2% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1994)), the substance was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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