GHS Classification Result

Chemical Name：benzyl alcohol
CAS：100-51-6

Result：
ID: 20A2028
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Not classified - - - - Its flash point is 101degC (Ullmanns (E) (2003), which is > 93degC.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen that is chemically bonded only to carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		The rat LD50 values are documented to be 1610mg/kg (SIDS (2008)) (Directive 84/449/EEC guidelines compliant), 1230mg/kg (PATTY (5th, 2001)), 2080mg/kg (SIDS (2008)), and 3100mg/kg (PATTY (5th, 2001)). Based on the data complying with EEC guidelines, and selecting the category of greater hazard, the substance was classified into Category 4.
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Since the rabbit LD50 = 2000mg/kg (SIDS (2008)), the substance was classified into Category 4.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Among documented rat LC50 values: > 4.178mg/L (SIDS (2008)) (OECD TG 403; GLP-compliant), rat LC50 values: 8.9mg/L (SIDS (2008)), and 8.84mg/L (4-hour conversion: 12.5mg/L/4h) (PATTY (5th, 2001)); the GLP-compliant data of > 4.178mg/L and the category of greater hazard (8.9mg/L) were considered in evaluation. Based on JIS classification criteria, the substance was classified into Category 3. Since its toxic concentration (2012 ppmV) is higher than 90% of saturated vapour pressure concentration (123.6 ppmV; 25degC), it was judged that the substance was in the vapour state.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Not classified - - - - The primary skin irritation index values (PII values) of 1.56 and 1.83 were documented from 2 rabbit Draize tests (ECETOC TR 66 (1995)). Since both values are less than 2.3, the substance was classified into "Not classified".
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Since results of eye irritation tests using rabbits (OECD TG 405) showed that the substance was moderately irritating (SIDS (2008)), it was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Classification not possible due to lack of data. Although positive reactions were detected in 1% of 2261 volunteers who took patch tests, on the other hand, no sensitization reactions were detected in 25 people tested, to whom the maximum administration doses (10% concentration, 48 hours * 5 times) were applied.
5 Germ cell mutagenicity Not classified - - - - Based on negative results (SIDS (2008)) from in vivo micronucleus tests using mice that underwent intraperitoneal administration (OECD TG474) (in vivo mutagenicity tests using somatic cells), the substance was classified into "Not classified". Many in vitro mutagenicity studies, such as Ames tests, point mutation tests using E. coli, and cytogenetical tests using CHO cells, have been documented, and 13 out of 20 cases (excluding some ambiguous results) yielded negative results (SIDS (2008)) and 3 cases yielded positive results (SIDS (accessed in June 2008)).
6 Carcinogenicity Not classified - - - - According to evaluations of carcinogenicity tests (OECD TG451), industrial benzyl alcohol showed no carcinogenic effects after 2 years of exposure at the doses that cause no toxic effects (<= 400mg/kg bw in rats and <= 200mg/kg bw in mice). Therefore, the substance was classified into "Not classified". As additional notes, the maximum dose used in the 2-year study was determined by preliminary studies (16-day and 13-week tests) (SIDS (2008); NTP TR 343 (1989)).
7 Reproductive toxicity Classification not possible - - - - According to 4-generation, oral administration studies using rats, no effects on fertility, lactation, development, or teratogenicity were documented at the administration dose of 750mg/kg/day and under. However, data on developmental toxicity of the offspring were insufficient and thus the substance was classified into "Classification not possible".
8 Specific target organ toxicity - Single exposure Classification not possible - - - - The rat LD50 values (oral route) are 1230mg/kg and 1660mg/kg, and the mouse LD50 (oral route) is 1360mg/kg; from inhalation tests using rats or mice (RTECS (2007)), neurotoxic symptoms such as drowsiness, coma, and motor ataxia were documented (RTECS (2007)). However, since these data were of List 3, the substance was classified into "Classification not possible".
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In forced oral administration tests using rats (50, 100, 200, 400, and 800mg/kg/d for 13 weeks), neurotoxic symptoms (labored breathing and coma) were observed at 800mg/kg/d, a dose that is equivalent to the guidance values of "Not classified" (SIDS (2008); IUCLID (2000)). However, since there were no data on other exposure routes, the substance was classified into "Classification not possible".
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Since its 96-hour LC50 = 460mg/L for fish (fathead minnow) (SIDS, 2004), 48-hour EC50 = 230mg/L for crustaceans (Daphnia magna), and 72-hour EC50 = 770mg/L for algae (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1997), the substance was classified into "Not classified".
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since it is water soluble (water solubility = 40g/L (SIDS, 2004)) and its classification for acute toxicity is "Not classified", the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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