GHS Classification Result

Chemical Name:tetrahydro-2-furylmethanol; tetrahydrofurfuryl alcohol
CAS:97-99-4

Result:
ID: 20A2026
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Its flash point is 84degC (Merck No. 9213), which is <= 93degC and >= 60degC.
7 Flammable solid Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified - - - - Its autoignition point is 282degC (HSDB (2003)), which is > 70degC.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Since exposure to the substance at 2000mg/kg did not cause mortality in rats (OECD TG 423) (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council) (2008)), the substance was classified into "Not classified".
1 Acute toxicity (Dermal) Classification not possible - - - - Insufficient data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - - Since its rat LC50 (6hr) = 52.8mg/L (4-hour conversion: 79.2mg/L) (SIDS (2005)), the substance was classified into "Not classified".
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Since the substance is documented as moderately irritating to guinea pigs and humans (SIDS (2005), PATTY (5th, 2001), it was classified into Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
In several studies using rabbits, the substance was characterized as "not irritating," "irritant," and "moderate to severe irritation." While information regarding the effects of the substance on humans is scarce, one literature addressed the substance as a severe eye irritant (SIDS (2005)). Based on these results and information, the substance was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible - - - - In vitro mutagenicity tests (Ames tests and chromosomal aberration tests) provided negative results only (SIDS (2005)). Since there were no in vivo data available, classification is not possible.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In the preliminary reproductive toxicity screening tests, the substance was orally administered to male rats for 47 days, starting 14 days before mating; and female rats underwent oral administration that started 14 days before mating and ended after 4 days from the onset of lactation (OECD TG 421). In these tests, extended estrous cycle and failed parturition were observed, and early embryo resorption was detected in females being administered 500mg/kg/day by uterus examination. At the administration dose of 150mg/kg/day or higher, a prolonged gestational period, and decreased pregnancy rate, delivery rate, birth rate, and survival rate 4 days after birth were observed (SIDS (2005)). Furthermore, oral administration tests at 500mg/kg/day or higher during the organogenetic period resulted in early resorption in 100% of treated female rats (SIDS (2005)). At these toxic doses, decreased body weight gain and decreased food consumption in parental animals were observed. Because reproductive toxicity, such as early resorption, and decreased delivery rate and birth rate were detected at the doses that cause general toxicity to parental animals, the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects) Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
According to DHP 13th (2002), the substance was characterized as "fatal dose: 2300mg/kg, irritation: +, CHS effects: +", which indicates its effects on the central nervous system at the doses above the guidance values. The oral administration of 2000mg/kg to rats caused decreased locomotor activity and hypotonia 1 hour after administration, which disappeared the following day (SIDS (2005)). In addition, the following symptoms were noted: loss of coordination, prostration, vasodilation at 2.38mg/L/4hr (vapour) (PATTY (5th, 2001)); narcotic effects in acute toxicity tests using mice (LD50 = 2300mg/kg) (RTECS (2000)); and acute symptoms via inhalation such as giddiness, drowsiness, and unconsciousness (ICSC (J) (1994)). Based on these documents, the substance was classified into Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Category 2 (spleen, testis) Warning H373: May cause damage to organs through prolonged or repeated exposure (spleen, testis) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In 2 studies in which rats underwent 13-week inhalation exposure (vapour) at 50-500ppm (0.209-2.089mg/L/6hr), hypoactivity and intermittent whole spasms occurred and hyperactivity followed. Intermittent systemic spasm occurred in a dose-dependent fashion (SIDS (2005)), and the symptom became hardly noticeable in 1 hour. Since 500 ppm is only slightly above the upper limit of the Category 2 guidance values, these observed neurotoxic effects are considered to be not serious. 28-day repeated oral administration tests using rats resulted in capsulitis of the spleen and necrosis of seminiferous epithelium of testes at 150mg/kg/day (90-day correction: 46.7mg/kg/day) or above (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Council) (accessed in May 2008). From these results, the substance was classified into Category 2 (spleen, testis).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Based on its 96-hour LC50 > 100mg/L for fish (medaka), 48-hour EC50 > 92mg/L for crustaceans (Daphnia magna), and 72-hour EC50 > 100mg/L for algae (Pseudokirchneriella subcapitata) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 2002), the substance was classified into "Not classified".
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - It is water soluble (water solubility > 250g/L (SIDS, 2006)) and its classification for acute toxicity is "Not classified". Based on the information, the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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