GHS Classification Result

Chemical Name:o-nitroaniline
CAS:88-74-4

Result:
ID: 20A2015
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - Although oxygen balance data are available (-196.9), there are no data on exothermic decomposition energy. Thus, classification is not possible.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solid Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Classification not possible - - - - No data available.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Since its autoignition point is 521degC, the substance does not ignite spontaneously at room temperature.
11 Self-heating substances and mixtures Classification not possible - - - - Melting point: 69-71degC (CERI 2006). Since the substance is solid with its melting point <= 140degC, the current testing method is not applicable.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available.
15 Organic peroxides Not applicable - - - - Containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - The substance is solid with its melting point at 69-71degC (CERI 2006). Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Of the rat LD50 values of 1838mg/kg (female) and 3560mg/kg (male) (SIDS (2001)) documented, the female value, which is the lower of the two, was used for the basis to classify the substance into Category 4.
1 Acute toxicity (Dermal) Not classified - - - - Based on the rabbit LD50 > 20000mg/kg (SIDS (2001)), the substance was classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - The documented LC50 of > 2.529mg/L (SIDS (2001)) failed to specify an appropriate category, thus, classification is not possible.
2 Skin corrosion/irritation Not classified - - - - In the 24-hour Draize Test in which the substance was applied to rabbit skin, the substance was found to be not irritating (SIDS (2001)). Thus, it was classified into "Not classified".
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
In the Draize Test using rabbits, the substance was found to be slightly irritating (SIDS (2001)). Thus, it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Not classified - - - - In both the maximizing test in guinea pigs (SIDS (2001)) and patch test in humans (SIDS (2001)), the substance was found to be not sensitizing. Thus it was classified into "Not classified".
5 Germ cell mutagenicity Not classified - - - - Based on negative results obtained from micronucleus tests in which mice underwent intraperitoneal administration (SIDS (2001)) and tests conducted by Bayer in 1993 and Monsant in 1989 (IUCLID (2000)), the substance was classified into "Not classified". Also, reverse mutation tests using microorganisms yielded negative results (SIDS (2001)). Regarding the positive results obtained from chromosomal aberration tests using CHL/IU (SIDS (2001)), cytotoxicity was extremely high and the data has little biological significance.
6 Carcinogenicity Classification not possible - - - - No data available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
In Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Tests using rats (exposure period of approx. 9 weeks), high doses were associated with decreased litter size, decreased offspring survival rate at 4 days after birth, and increased offspring mortality, which were statistically significant. In the same tests, general toxicity, such as decreased body weight and clinical symptoms, were observed in parental animals (SIDS (2002)). Therefore, the substance was classified into Category 2.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Classification is not possible because doses that were associated with observed symptoms in oral route and inhalation exposure tests using rats (SIDS (2001), HSDB (2008)) were not provided.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Tests using rats (exposure period of approx. 9 weeks), no effects of the substance were observed except for decreased body weight gain at a high dose administration (450mg/kg/day) (SIDS (2001)). In addition, in 28-day inhalation tests using male rats, no adverse effects were observed other than subtle changes in blood parameters such as increased methemoglobin at a high dose administration (90mg/m3) (SIDS (2001)). Despite these results, classification is not possible due to insufficient data: the only species tested was rats, only screening tests were performed, and only male rats were used.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
Since its 24-hour EC50 = 8.3mg/L for crustaceans (Daphnia magna) (SIDS, 2003), the substance was classified into Category 2.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Its classification for acute toxicity is Category 2 and it is not rapidly degradable (non-biodegradable, degradability: 0% (SIDS, 2003)), 72-hour NOEC is >= 100mg/L (SIDS, 2003) for algae (Pseudokirchneriella subcapitata) (SIDS, 2003). Based on the information, the substance was classified into "Not classified".


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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