GHS Classification Result （Revision of the past classification result）

Chemical Name：Methylamine
CAS：74-89-5

Result：
ID: 1-423
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - - -
2 Flammable gases （including chemically unstable gases） - - - - - -
3 Aerosols - - - - - -
4 Oxidizing gases - - - - - -
5 Gases under pressure - - - - - -
6 Flammable liquids - - - - - -
7 Flammable solids - - - - - -
8 Self-reactive substances and mixtures - - - - - -
9 Pyrophoric liquids - - - - - -
10 Pyrophoric solids - - - - - -
11 Self-heating substances and mixtures - - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - - -
13 Oxidizing liquids - - - - - -
14 Oxidizing solids - - - - - -
15 Organic peroxides - - - - - -
16 Corrosive to metals - - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is a description of LD50 value 100-200 mg/kg (ACGIH (7th, 2001), DFGOT vol.7 (1996)), and 698 mg/kg (DFGOT vol.7 (1996), IUCLID (2000)) of the oral administration test where 40% solution was administered to a rat. Moreover, there is description of 100-200 mg/kg (DFGOT vol.7 (1996), Patty (5th, 2001) and IUCLID (2000), HSDB (2008)) as LD50 value of the test where 10% solution was administered orally to a rat. Since two or more LD50 values fall within the range of Category 3, it was classified into Category 3.
1 Acute toxicity （Dermal） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Gases） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Since LC50 values of the 4-hour inhalation exposure test employing rats were 4,400 mL/m3 (4,400 ppm), and 6,400-9,100 mL/m3 (6,400-9,100 ppm) (DFGOT vol.7 (1996)), it was classified into Category 4.
1 Acute toxicity （Inhalation: Vapours） Not applicable - - - - Since it was gas on a GHS definition, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Dusts and mists） Not applicable - - - - Since it was gas on a GHS definition, it was classified into "Not applicable".
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there is no data of skin irritation test with this substance (gas), the solution seems to have a skin corrosion from descriptions that 40% solution causes a necrosis on skin of rabbits (Patty (5th, 2001)) and that "40% solution causes a necrosis on skin of guinea pig 40%" (ACGIH (7th, 2001)). It was classified as Category 1with unknown further data and without subdivision. In addition, a solution with 10% or more of this substance concentration can be classified as R34 in the EU classification (EU-Annex I).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Although there is no data of eye irritation test with this substance (gas), it has been described that "serious irritation was developed in eyes of rabbits" with 40% solution (ACGIH (7th, 2001)), or that "corneas were damaged 5 minutes after exposure" (Patty (5th, 2001)). This substance was classified into Category 1since it was a skin corrosive substance, and there have been descriptions of "irritative, European Union classification: risk of serious damage to eyes" in the eye irritation test with 40% solution employing rabbits (IUCLID (2000)) and of "corrosive to eyes" in the section of short term exposure, ICSC (2003) although there was no description about recovery properties.
4 Respiratory sensitization Classification not possible - - - - It has been described that "one worker had an allergic or irritative bronchitis" (ACGIH (7th, 2001), NTP DB (Access on January 2009), and Patty (5th, 2001)).
4 Skin sensitization Classification not possible - - - - Classification is not possible since this case is the only case report with non-public and unspecified data.
5 Germ cell mutagenicity Classification not possible - - - - Although there is a description of "positive" (NTP DB (Access on January 2009), IUCLID (2000)) in a productive cell in vivo heritable mutagenicity test (dominant lethal test by inhalation exposure employing a rat), there is a statement that "the test details are unknown and it cannot be evaluated."(IUCLID (2000)). Classification is not possible because there is no other data of in vivo examination. In addition, there are descriptions of "positive" in the mouse lymphoma assays and "negative" (NTP DB (Access on January 2009)) in the reverse mutation test employing salmonella as an in vitro mutagenicity test.
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - There is a description as follows in the inhalation exposure test using pregnant rats, "Although fetal death after implantation increased depending on the dose level, evaluation cannot be made, because study details are unknown" (DFGOT vol.7 (1996). Moreover, there is a description as follows in the reproductive toxicity study via oral administration using female rats, "Although no effect related with administration was observed on estrous cycles, reproductive capabilities, pregnancy, live baby birth, breast feeding, average body weight of baby animals at birth and at weaning, significant decrease in the number of fetuses per litter was observed"(NTP DB (Access on January 2009), IUCLID (2000)). It has been concluded as follows regarding this in IUCLID (2000), "No evaluation can be made because details of results are unknown." On the other hand, there are descriptions as follows in the reproductive toxicity study via administration into the ventral cavity using female mice, " No toxicity was observed in mother animals and child animals" (NTP DB (Access on January 2009), IUCLID (2000)) and "No reproductive toxicity was observed" (IUCLID (2000)). Classification is not possible, because sufficient data are not available as mentioned above.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system) Danger H370: Causes damage to organs (respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In Japan Assoc. of Industrial Health (1979) recommendations, there are descriptions of "Cough and breathing difficulty occur," "Oppressive irritation at 100 to 500 ppm occurs, and temporary irritation of the eye, nose, and throat at 20-100 occur in a short time." and "The inflammation of tracheal gill, bronchus, and lungs and the lung blister occur if the high concentration at lethal dose or near the lethal dose was inhaled." in animals. Moreover, there are descriptions of "Dronchial pneumonia occurred and was critical depending on dosage" in the inhalation exposure test employing rats (DFGOT Vol.7 (1996)) and of "Corrosiveness is shown to the airway. When high concentration is inhaled, lung edemas may occur."(ICSC (2002)). Furthermore, there is description of "Aliphatic amines may irritate an airway and cause difficulty breathing, upper respiratory tract disorder, bronchitis, pneumonia and lung oedema. Moreover, headache, nausea, weakness and anxiety neurosis may be temporarily caused after inhalation" (HSDB (2008)), and there is description of "This guideline is based on the information on low molecular weight amines including Methyl amine." in BASF Chemical Emergency Medical Guidelines Aliphatic amines (Reviewed 2006) which is the attribution of this information. As mentioned above, it was classified into Category 1 (respiratory system).
9 Specific target organ toxicity - Repeated exposure Category 2 (respiratory system, liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (respiratory system, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the 4-month nasal i inhalation exposure test in male and female rats, "there are reports of functional disorders in nervous system, liver and blood enzyme, and changes in immunologic indicators and the shape of organs, but there is no report about detailed method or data " (DFGOT vol.7 (1996), IUCLID (2000)). Moreover, HSFS (2004) shows that "the substance may cause lung irritation and bronchitis. High-concentration exposure may have effects on liver function." Therefore, it is classified into Category 2 (respiratory systems, liver).
10 Aspiration hazard Not applicable - - - - Due to the fact that the substance is gas according to the GHS definition, it is classified as "Not applicable".

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information