GHS Classification Result

Chemical Name:Hydrazine sulfate
CAS:10034-93-2

Result:
ID: 2-098
Classifier: Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Although it is hydrazine salt, it has been classified into Class 8 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods and was classified into Not classified. In addition, this TDG classification is based on the UN No.2923 by Merck KGaA data from March 2009.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Not classified - - - - Since it was classified into Class 8 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods and it is not Class 4.1(II), 4.1(III), it was classified into Not classified. In addition, this TDG classification is based on the UN No.2923 by Merck KGaA data from March 2009.
8 Self-reactive substances and mixtures Not classified - - - - Since it was classified into Class 8 (not 4.1) and PG III in the United Nations Recommendations on the Transport of Dangerous Goods, it was classified into Not classified. In addition, this TDG classification is based on the UN No.2923 by Merck KGaA data from March 2009.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Since it was classified into Class 8 (not 4.2) and PG III in the United Nations Recommendations on the Transport of Dangerous Goods, it was classified into Not classified. In addition, this TDG classification is based on the UN No.2923 by Merck KGaA data from March 2009.
11 Self-heating substances and mixtures Not classified - - - - Since it was classified into Class 8 and PG III, not Class 4.2 (II) and 4.2 (III), in the United Nations Recommendations on the Transport of Dangerous Goods, it was classified into Not classified. In addition, this TDG classification is based on the UN No.2923 by Merck KGaA data from March 2009.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not classified - - - - Since it was classified into Class 8 and PG III, not Class 5.1 (I), 5.1 (II) and 5.1(III), in the United Nations Recommendations on the Transport of Dangerous Goods, it was classified into Not classified. In addition, this TDG classification was considered to be based on UN No.2923 by Merck KGaA data from March 2009.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
From a description of LD50 value of 670 mg/kg (BUA 205 (1996)) and 601 mg/kg (HSDB (2005)) in the oral administration test employing rats, it was classified into Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - Although there is a description that LD50 value of the dermal administration test employing a rabbit is 91 mg/kg (BUA 205 (1996)) for [ID 56] Hydrazine (CAS 302-01-2), since it is not data of the substance itself, classification is not possible.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Although it is written that LC50 value of the 4-hour inhalation exposure test employing rats about [ID56] Hydrazine (CAS 302-01-2) is 0.35-0.76 mg/L (BUA 205 (1996)), classification is not possible since it is not data of this substance itself.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - Although it has been described as human data that "no irritation on the skin was shown even if 25% hydrazines sulfate or its concentrated solution was applied for 24 hours in the skin exposure test in volunteers" (CERI/NITE Hazard Assessment Report (2004)), this is a test data with dissolved solution for 24 hours. In addition, although it has also been described that "there was no macroscopically observable symptom" (CERI/NITE Hazard Assessment Report (2004)) in the tests in which the substance-dipped sponges were fixed to the external ears of rabbits for 24 hours, since all of the tests were conducted in 1950s with insufficient data, classification is not possible.
3 Serious eye damage/eye irritation Classification not possible - - - - Although in HSDB (2005), there is a description of "There was no damage." in the eye irritation test where 0.02 mol concentrations of diluted solution (about 0.26%) was dropped employing rabbits with a corneal being removed, since it is the excessive condition that a corneal is removed and dropped to allow a chemical to penetrate easily and is the test with a diluted solution, classification is not possible.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
It was classified as Category 1 since it has been described that "allergic contact dermatitis arose to plant employee who employed hydrazine sulfate" (EHC 68 (1987)), or that "it may have sensitizing properties to humans and cause contact dermatitis" (BUA 205 (1996)).
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Although in vivo genotoxicity test (sister chromosome fission exchange test employing a mouse) is negative (BUA 205 (1996)), in vitro mutagenicity test employing a Salmonella typhimurium is positive (EHC 68 (1987)), and there is a description of methylation (IARC 71 (1999)) of DNA in the body cell in vivo genotoxicity test employing a hamster. Although there is no data of in vivo mutagenicity test as sulfate, as hydrochloride salt (CAS number 2664-70-4), it is positive in body cell in vivo mutagenicity test (mouse spot test) (CERI/NITE Hazard Assessment Report (2004)). Although the water solubility of this substance was 1/10 of Hydrazine hydrochloride, it was considered that the affection comparable to that of Hydrazine hydrochloride reaches on a cell, and it was classified into Category 2.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
IARC evaluates Hydrazines as group 2B (IARC 71 (1999), EHC 68 (1987)) and NTP evaluates Hydrazine and Hydrazine sulfate as R (NTP RoC (11th, 2005)). Priority was given to the classification of IARC and it was classified into Category 2. In addition, as for tests in which this article was administered to animals, there is a report that hepatocellular carcinoma was developed in the 2-year drinking water medication test which employed hamsters (IARC 71 (1999)), and there are descriptions that lung adenomas was developoed in the repeated oral dose study employing rats and mice and that liver cancer was developed in the 36-week forcible oral administration examination employing mice (EHC 68 (1987)).
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, liver), Category 3 (respiratory tract irritation) Danger
Warning
H370: Causes damage to organs (nervous system, liver)
H335: May cause respiratory irritation (respiratory tract irritation)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
There is a datum dermal administration test on Hydrazine which calculated the lethal dose employing rabbits, which has a description that "main influences of Hydrazine and Hydrazine sulfate salt are hepatotoxicity and the nephrotoxicity" as consideration (BUA 205 (1996)). Although these influences were seen within the limits of the guidance value of Category 1, it is unknown whether it is a view in the example of survival. About human data, as an accidents cases about [ID 56] Hydrazine (CAS 302-01-2), CERI/NITE Hazard Assessment Report (2004) has an case that "a worker who got the burn in explosion accident went into coma after 14 hours and his brain showed neurological symptoms, such as an activity fall, and the bloody urine and the impaired liver function without a kidney damage were seen three days after the accident", and another case that "the steep rise of the enzyme value relevant to the local irritation of nausea, vomiting, the exposure skin and a conjunctiva, and a top respiratory tract and liver toxicity were seen in workers exposed to steam for 4 to 5 hours. Since it was satisfactory to apply this data to the article, it is classified into Category 1 (a nervous system, liver) and Category 3 (Respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, adrenal gland), Category 2 (kidney, blood system, central nervous system) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (liver, adrenal gland)
H373: May cause damage to organs through prolonged or repeated exposure (kidney, blood system, central nervous system)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In several cases where cancer patients were prescribed Hydrazine sulfate, it was reported that "disorders of the central nervous system were seen in some, and when the dosing period was long severe cases of polyneuropathy syndrome were observed" (ATSDR (1997)). However, the report concluded that "The subjects were not healthy individuals so it is possible that the symptoms which presented may be caused by underlying conditions," so it was not used. On the other hand, HSDB (2005), which is the source of information for List 2, contains reports on humans that "a man who received oral administration for 3-4 months presented hepatic encephalopathy, kidney failure and severe coagulopathy," and "a man who received it for 7 weeks suffered severe cerebropathia." For animals, there are reports that "brown discoloration was observed as non-tumorous lesions in the adrenal gland" in a 25-week oral carcinogenicityity study in mice and that "hepatic lesions, reticuloendothelial cell hyperplasia, liver cirrhosis and bile duct hyperplasia were observed" in 15- and 25-week oral gavage administration study in hamsters (EHC 68 (1987)). Since the effects for both mice and hamsters are within the range of guidance values for Category 1, it was classified as Category 1 (liver, adrenal gland) and Category 2 (kidney, blood system, central nervous system).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - No data available
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

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Model SDS by MHLW

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