GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：2-(1,3-Thiazol-4-yl)-1H-benzoimidazole
CAS：148-79-8
Result：
| ID: | 2-055 |
| Classifier: | Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE） |
| Year Classified: | FY2008 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （Sep, 2008） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid |
| 7 | Flammable solids | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included. |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | It is an organic compound not containing oxygen, fluorine or chlorine. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | The organic compound not including peroxy group in molecule. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | It was classified into "Not classified" from LD50 value of 4,700 to 5,100 mg/kg (JECFA (2001)) of the oral administration test (GLP) employing a rat. |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | From a description of LD50 value of >2,000 mg/kg (JECFA (2001)) in the dermal administration test employing rabbits, it was classified into "Not classified". |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable". |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | Saturated vapor pressure level at 25degCis 8.23*10^-5 mg/m3. Since LC50 value with >0.4 mg/L of the 4-hour inhalation exposure test employing rats (JECFA (2001)) is larger than saturated vapor pressure level, classification cannot be specified when applying the dust and mist standard, and classification is not possible. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | Classification is not possible since there is no data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | Classification is not possible because of insufficient data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Although there is a description of "positive" in the mutagenicity test employing in vitro bacteria (NTP DB (Access on October 2008)), classification is not possible because there is no data of in vivo examination. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | HSDB (2003) has a description that "there is no evidence of carcinogenicityity in any of the short-term and long-term examinations in many of animals", however, classification is not possible since no evaluation by major international evaluation agencies has been made. |
| 7 | Reproductive toxicity | Category 1B |
|
Danger | H360: May damage fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
A primary document (Food Chem Toxicol.22 (1984)) of the study with mice published in JECFA (2001) was acquired for the thorough review and found a description as follows, "Significant body weight reduction with fetuses, significant increase in external surface abnormalities such as cleft palates, significant decrease in the number of live fetuses and significant increase of skeletal abnormalities such as fusion of vertebral arch and vertebra were observed at the dose level where suppression of body weight, increase in weight of the liver, heart, lien and kidney can be observed." For the reasons stated above, it was classified as Category 1B. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (kidney) |
|
Danger | H370: Causes damage to organs (kidney) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
The oral administration test employing a mouse has a description that "the nephrotoxicity of dose-dependent is caused. The effect of this substance reaches to the maximum in 2 or 3 days then is recovered afterward" (JECFA (2001)). Since these influences were seen within the limits of the guidance value of Category 1, they were taken as Category 1 (kidney). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (kidney, thyroid, hematopoietic system) |
|
Warning | H373: May cause damage to organs through prolonged or repeated exposure (kidney, thyroid, hematopoietic system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
There are descriptions of "Thyroid weight increase, hypertrophy of a thyroid follicle cell, hyperplasia of red corpuscle of bone marrow, the increase in the number of blood platelets" occur in 13-weeks oral administration test employing rats. (JECFA (2001)) and of "splenic extramedullary hematopoiesis increase, vacuolization of the dose-dependent nephric tubule in the female, and the increased hemosiderin deposition of a lienal" are produced " in 52-weeks oral administration test employing dogs (JECFA (2001)). Since these influences were seen within the range of the guidance value of Category 2, it was classified into Category 2 (kidney, thyroid gland, blood system). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 48 hours EC50=0.31mg/L of the crustacea (Daphnia magna) (AQUIRE (2008)). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Since acute toxicity was Category 1 and there were no rapid degradability (BIOWIN), it was classified into Category 1. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |