GHS Classification Result

Chemical Name：2,3-Dibromopropan-1-ol
CAS：96-13-9

Result：
ID: 2-047
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Classification not possible - - - - Classification not possible due to lack of data
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Classification not possible - - - - Classification not possible due to lack of data
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		It was classified into Category 4 from LD50 value of 681mg (RTECS (2008))/kg of the oral administration test employing a rat. In addition, in EU classification, Xn; R20/22 (EU-Annex I).
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from LD50 value of 316mg/kg (RTECS (2008)) of the dermal administration test employing a rabbit. In addition, the EU classification is R24 (EU-Annex I).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Saturated vapor pressure level at 25degCis 118.4 ppm (1.06 mg/L). Since LC50 value with 9.92 mg/L of the 4-hour inhalation exposure test employing rats (RTECS (2008)) was larger than saturated vapor pressure level, it was classified into "Not classified" by applying the dust and mist standard. In addition, the EU classification is R20/22 (EU-Annex I).
2 Skin corrosion/irritation Classification not possible - - - - Classification is not possible because there is no data. In addition, it has been described that "hyperkeratosis and epithelial neoplasm on the dosing side of skin of almost half of rats with dose of 375 mg/kg" (NTP TR400 (1993)) were observed in the repeated dermal administration test with rats.
3 Serious eye damage/eye irritation Classification not possible - - - - Classification not possible due to lack of data
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Classification is not possible since there is no data.
5 Germ cell mutagenicity Not classified - - - - Since it was negative in the body cell in vivo mutagenicity test (micronucleus test which employed the the mouse bone marrow cell) (IARC 77 (2000), NTP DB (Access on September 2008), NTP RoC (11th, 2002), NTP TR 400 (1993)), it was classified into "Not classified".
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		IARC evaluates it as group 2B (IARC 77 (2000)), Japan Society for Occupational Health evaluates it as 2B (Recommendation of Occupational Exposure Limits (2006)), classification of NTP is R (NTP RoC (11th, 2002)) and the European Union classification is 2 (EU-Annex I). Priority was given to the classification of IARC and it was classified into Category 2. In addition, there is a description that "the increase in lung adenomas and localized hyperplasia of the bronchus lid epithelium were seen" in the 36 to 39-week dermal administration test employing male mice, and in the 39 to 42-week dermal administration test employing female mice (IARC (2000)), and there is possibility of being carcinogenicity on respiratory organs.
7 Reproductive toxicity Classification not possible - - - - In a morphological study of sperm and an examination of vaginal cells in rats (NTP TR400 (1993)) it is reported that the sperm motility of the administered rats was not affected but that their sperm concentration decreased. On the other hand, it is reported that there were no changes in the length of the estrus period or the relative frequency of the various estrus stages (NTP TR400 (1993)). Since the effect on reproductive functions is unclear, classification is not possible. Incidentally, the EU classification is Cat. 3; R62 (EU-Annex I).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Classification not possible due to lack of data
9 Specific target organ toxicity - Repeated exposure Category 2 (digestive system, kidney, liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (digestive system, kidney, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It is written in 48 to 55-week dermal administration test in rats that "there were hyperkeratosis in anterior stomach and esophagus, increased rate of incidence of epithelial hyperplasia in nose, pleomorphism of cells in liver, and apparent basophilic cellular changes, in addition, nuclear enlargement in kidney, ulcer and acanthokeratodermia in anterior stomach, vasodilatation in liver, hyperplasia of kidney in males, and epithelial dysplasia in anterior stomach, and hyperplasia of bile duct in females" (IARC 77 (2000), NTP TR400 (1993)). Moreover, it is written in 36 to 42-week dermal administration test in rats that there were epithelial dysplasia of anterior stomach, and increased rate of incidence of pleomorphism of bronchiolar epithelium (IARC (2000), NTP TR400 (1993)). Since all were found within the scope of the guidance value of Category 2, it was classified into Category 2 (digestive system, kidney, liver). Since there is a possibility of incidence by inhalation of the applied sample about the respiratory system, and classification cannot be specified, it is not adopted, however, cautions are required since it could have some adverse effects on the respiratory system. Refer to the carcinogenicity section about the respiratory system. In addition, it is written in sperm morphology test and cytodiagnosis of vagina that "the weight of tails, testis, and epididymis of rats administered remarkably decreased"(NTP TR400 (1993)), the testis is considered to be a target organ, however, it is not adopted because a route of administration is unknown, and classification cannot be specified.
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 96 hours LC50=71mg/L of the fish (Fathead Minnows) (AQUIRE (2008)).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 3 and there were no rapid degradability (BIOWIN), it was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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