Chemical Name：N,N'-(3,3'-Dichlorobiphenyl-4,4'-diyl)diammonium dichloride
CAS：612-83-9

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Although it was equivalent to the U.N. GHS acute toxicity Category 5 employing a rat from LD50 value 3,820 mg/kg (CaPSAR (1993), IUCLID (2000)) of the oral administration test, they fell under unadopted category in Japan and were classified into "Not classified".
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	Classification is not possible because there is no data. EU classification is Xn; R21 (EU-Annex I). In addition, there is a data of LD80 value 1,000 mg/kg (CICAD 2 (1998)) of the dermal administration test employing rabbits about free base (CAS 91-94-1).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	Classification not possible due to lack of data
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Classification not possible due to lack of data
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	Classification is not possible because there is no data. Also, for free bases (CAS 91-94-1), "no irritation" has been indicated in data from the skin irritation test with rabbits (IUCLID (2000)).
3	Serious eye damage/eye irritation	Category 1		Danger	H318: Causes serious eye damage	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician.	From a description of "It has severe eye irritation compared with a free base and causes actinic erythema and corneal opacity and AOI is 84, and 70 even after 7 days."(ACGIH (7th, 2001), IUCLID (2000)) in the eye irritation test employing rabbits, it was classified into Category 1.
4	Respiratory sensitization	Classification not possible	-	-	-	-	Classification is not possible since there is no data.
4	Skin sensitization	Classification not possible	-	-	-	-	Classification is not possible since there is no data. It can be classified as R43 (EU-Annex I). Also, for free bases (CAS 91-94-1), there is a description of "having caused contact dermatitis in working employees" (CICAD 2 (1998)).
5	Germ cell mutagenicity	Category 2		Warning	H341: Suspected of causing genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Although there are descriptions that TA1535 was "negative" in the in vitro mutagenicity test (reverse mutation test employing bacterial cells), that TA100 and TA1537 were "positive only in case of having S9 metabolic activation" and that TA98 was "positive" (ACGIH (7th, 2001), NTP DB (Access on September 2008)), there is no data of in vivo examination. However, for the isolation base with lower solubility than that of this substance (CAS 91-94-1), since there was a description of "positive" in the body cell in vivo mutagenicity test (the micronucleus tests which employs the mouse bone marrow cell, the chromosome aberration test using the mouse bone marrow cell) (CICAD 2 (1998)), this data was applied to this substance and it was classified into Category 2.
6	Carcinogenicity	Category 2		Warning	H351: Suspected of causing cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	The evaluation is divided as IARC's classification is Group 2B (suppl.7 (1987)), NTP's classification is R (NTP RoC (11th, 2005)), and European Union classification is 2 (EU-Annex I), however, the evaluation year of NTP RoC (11th, 2005) is 1981, and the evaluation year of EU is unknown. Since the argument of whether animal data can apply to humans was also insufficient, it classified into Category 2 by giving priority to the classification of IARC (1987).
7	Reproductive toxicity	Classification not possible	-	-	-	-	Classification is not possible because there is no data. Moreover, There is a description about free bases (CAS 91-94-1)as follows, "Although increase in the development of lymphocytic leukemia was observed among newborns from pregnant mice administered in the subcutaneous administration study with mice, no statistically significant defference has been shown."(CICAD 2 (1998).
8	Specific target organ toxicity - Single exposure	Category 3 （Respiratory tract irritation）		Warning	H335: May cause respiratory irritation (respiratory tract irritation)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	Since it was described as "upper respiratory tract irritation ant" by ACGIH (7th, 2001), it was classified into Category 3 (Respiratory tract irritation).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	For humans, there are reports that "upper respiratory tract infections and pharyngitis were observed in workers using this substance, but a causal relation could not be established" (ACGIH (7th, 2001), ATSDR (1998)). Since the data is insufficient, however, classification is not possible.
10	Aspiration hazard	Classification not possible	-	-	-	-	Classification not possible due to lack of data

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 96 hours LC50=0.66mg/L of the fish (Oryzias Latipes) (MOE eco-toxicity tests of chemicals (2002)).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and there were no rapid degradability (BIOWIN), it was classified into Category 1.