GHS Classification Result

Chemical Name：5-Allyl-1,3-benzodioxole
CAS：94-59-7

Result：
ID: 2-021
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Not classified - - - - Since the flash point by HSDB(2005) is 100degC(closed type), it was classified into Not classified.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Classification not possible - - - - Although the unsaturated bond is included in chemical structure, classification is not possible with no data.
9 Pyrophoric liquids Classification not possible - - - - Classification not possible due to lack of data
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		It was classified into Category 4 from LD50 value 1,950 mg/kg (JECFA (1980), HSDB (2005)) of the oral administration test employing a rat. In addition, in EU classification, it is Xn; R22 (EU-Annex I).
1 Acute toxicity （Dermal） Not classified - - - - From a description of LD50 value of >5,000mg/kg (HSDB (2005)) in the dermal administration test employing rabbits, it was classified into "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - There are descriptions, "moderately irritating" (HSDB (2005)) in the 24.hour study with rabbits and "not irritating" (HSDB (2005)) in the skin irritation test with mouse. Since the primary literature of these data is not available and details are unknown, classification is not possible. Moreover, there is a description, "Moderate" (RTECS (2007)) in the 24 hour Draize test with rabbits, although it is from an information source of List 3.
3 Serious eye damage/eye irritation Classification not possible - - - - Classification not possible due to lack of data
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Although there is a "negative" (HSDB (2005)) description in the Maximization test of humans (25 volunteers), classification is not possible because of insufficient data since it is the source of information from List2.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there were descriptions of "positive" (HSDB (2005)) in the body cell in vivo genotoxicity test (SCE test employing rat hepatocytes, DNA adduct formation test employing rat hepatocytes) and "positive" (mouse lymphoma test) (NTP DB (Access on October 2008)) in the in vitro mutagenicity test, and "negative" (chromosome aberration test employing a CHO cell) (NTP DB (Access on October 2008)), it was classified into Category 2 by experts' judgment. In addition, EU classification is Muta. Cat. 3; R68 (EU-Annex I).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it is classified into group 2B (IARC 10 (Suppl.7 1987)) according to IARC and was classified into Category R (NTP RoC (11th 2005)) according to NTP, it classified into Category 2. In addition, the European Union classification is Cat.2; R45 (EU-Annex I).
7 Reproductive toxicity Classification not possible - - - - Since there is no datum for the reproductive developmental toxicity study, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system) Warning H371: May cause damage to organs (central nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since "nausea, shock, cyanosis, hallucinations, circulatory collapse, spasm, a miosis, dizziness, sensory paralysis, aphasia, and respiratory depression" were described as a human acute symptom by HSDB (2005), it was classified into Category 2 (central nervous systems). Moreover, the examinations employing the rabbit which was data of the information source of List3 also has a description of "spastic paralysis and motor ataxia" within the limits of the guidance value of Category 2 (RTECS (2007).) .
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, skeletal muscle) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, skeletal muscle) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Since "damage in liver" (JECFA (1980)) was observed in the oral administration test in male and female rats, and "skeletal muscle atrophy", "severe liver fat infiltration" and "atrophy and necrosis of hepatocytes " (JECFA (1980), HSDB) were observed in the oral administration test in male and female dogs within the limits of the guidance value of Category 2, it is classified into Category 2 (liver, skeletal muscles).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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