GHS Classification Result

Chemical Name:2-[(Tolyloxy)methyl]oxirane
CAS:26447-14-3

Result:
ID: 2-014
Classifier: Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Not classified - - - - Since the flash point by IUCLID(2000) is approx. 125degC (closed type), it was classified into Not classified.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Classification not possible - - - - Although the strained epoxy ring is included, classification is not possible with no data.
9 Pyrophoric liquids Classification not possible - - - - Classification not possible due to lack of data
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Although there is description of LD50 value 5,800 mg/kg (Patty (5th, 2001)), 4,300 mg/kg (IUCLID (2000)) and 5,140 mg/kg (HSDB (2006)) of the oral administration test employing a rat and minimum value of 4,300 mg/kg corresponded to the U.N. GHS acute toxicity Category 5, it fell under unadopted category in Japan and was classified into "Not classified".
1 Acute toxicity (Dermal) Not classified - - - - Since it was written that LD50 value of the dermal administration test employing rats was >2,150 mg/kg (Patty (5th, 2001), IUCLID (2000)), and LD50 value of the dermal administration test employing rabbits was >2,000 mg/kg (IUCLID (2000)), it was classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - - Since it is written that LC50 value of the 4-hour inhalation exposure test employing rats is 1,220 ppm (equivalent: 8.19 mg/L) (Patty (5th, 2001), it was classified into "Not classified" by applying the mist standard from saturated vapor pressure level of this substance (25degC)with 0.38 mg/L . In addition, it is written in the information source of List2 that LC50 value of aerosol inhalation exposure test employing rats is 4.8-8.5 mg/L (IUCLID (2000)).
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Based on the description, "Draize score 5.2/8, moderate skin irritaqtion,"(Patty (5th, 2001)) in the study with rabbits it was classified in Category 2. Incidentally, EU division is Xi; R38 (EU-Annex I).
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Although Patty (5th, 2001) has described as "slightly irritating, It recovers rapidly." about the test employing rabbits, IUCLID (2000) has described as "moderately irritating, Draize Index 7.3", and since the substance is a skin irritation substance, it was classified into Category 2 according to Fig. 3.3.1 of U.N. GHS second edition.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
For humans, there are descriptions of "positive" in 2 of 4 lab technicians with occupational contact dermatitis in the patch test (HSDB (2006)) and of "hives reaction with pharyngeal tingling pain and hoarse voice" in the patch test in humans with clinical histories, such as a feeling of sweet itch and throat constriction by occupational exposure (HSDB (2006)). For animals, there is a description of "potent skin sensitizer" in the test with guinea pig (Patty (5th, 2001)). As mentioned above, it was classified into Category 1. In addition, it can be classified as R43 (EU-Annex I).
5 Germ cell mutagenicity Classification not possible - - - - Although Patty (5th, 2001) has described that "the biologically significant increase of a chromosome aberration is not found in the exposed human peripheral blood lymphocyte," when the cited reference (Mutat.Res.203 (1988)) was investigated, it was a test result about occupation exposure in the epoxy resin factory, and since there is a description that "the background level is high and the sensitivity is inadequate for detection of the cytogenetic influence of the feeble genetic toxicity substance", it is not adopted for classification. Classification is not possible because there is no other in vivo data. In addition, EU classification is Cat.3 and R68 (EU-Annex I).
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - Although there is a description as follows in HSDB (2006), "In inhalation exposure test effects on genital glands and fetuses were observed at a lower level of concentrations than the general toxicity level (2.55mg/m3), "classification is not possible due to insufficiency of data, because no more information is available from the cited literature (Indirect Food Additives and Polymers: Migration and Toxicology (2000)).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Although there is a description of "central nervous system prevention, myasthenia, liver damage, and a necrosis of a nephric tubule epithelium" in the acute toxicity tests employing rats, mice, and guinea pig (HSDB (2006)), classification is not possible since administration period and dose are unknown.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to lack of data
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 96 hours LC50=2.8-5.6mg/L of the fish (Rainbow Trout) (HSDB (2006), IUCLID (2000))
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 2 and there were no data about rapid degradability, it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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