GHS Classification Result

Chemical Name：Tritolyl phosphate
CAS：1330-78-5

Result：
ID: 1-460
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Not classified - - - - Since the flash point by Sax(8th,1992) is 210degC, it was classified into to Not classified.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data
9 Pyrophoric liquids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 410degC (HSDB,2003)).
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - It is stable in water (insoluble in water, Lide(88th,2007)).
13 Oxidizing liquids Classification not possible - - - - Although it is an organic compound including oxygen having chemically bound to elements other than carbon and hydrogen, classification is not possible due to lack of data.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - LD50 values of the oral administration test employing a rat are described to be 5,190 mg/kg, >4,640 mg/kg, and >15,800 mg/kg (EHC 110 (1990)). Although the latest LD50 value is >4,640 mg/kg, definite value 5,190 mg/kg was adopted, and it was classified into "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - From a description of LD50 value of >7,900 mg/kg (EHC 110 (1990)) in the dermal administration test employing rabbits, it was classified into "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Not classified - - - - It was classified into "Not classified" since there has been a description that "it has been reported that although o- and p-objects moderately irritated and m-object slightly irritated the skin of guinea pig, there was no irritation to isomer mixture " in the skin irritation test with guinea pig (the 4th volume of MOE Risk Assessment (2005)). In addition, there has been a description in RTECS (2008) of "mild" with unknown exposure time in the skin irritation test with rabbits.
3 Serious eye damage/eye irritation Classification not possible - - - - Although there is a description of "Steam may stimulate an eye only at high temperatures."(HSDB (2003)), since data is inadequate, classification is not possible.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Classification is not possible since there is no data.
5 Germ cell mutagenicity Classification not possible - - - - Although there are descriptions of "unscheduled DNA synthesis was not induced" in the body cell in vivo genotoxicity test (UDS test employing rat hepatocytes) (MOE Risk Assessment, Volume 4 (2005) ) and "negative" (NTP DB (Access on November 2008)) in chromosome aberration test using CHO culture cells in the in vitro mutagenicity test, in SCE test employing CHO culture cells, and in the reverse mutation test employing a Salmonella typhimurium, since there is no result of the in vivo mutagenicity test, classification is not possible.
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made, classification is not possible. In addition, there is a description that "neoplasm generating which is relevant to this mixture was not foreseen" in the two-year study in which male and female rats and male and female mice were administered with mixed feed of the preparation (21% of m-isomers, 4% of p-isomers, less than 1% of o-isomers, and others are structure un-identifying) containing 79% of this isomeric form mixture (NTP TR433 (1994)).
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is a description as follows in the study using rats of 6-18 day pregnancy, "Although the death rate of mother animals increased at higher dose levels, no significant defference was observed in the development frequency of deformation" (EHC 110 (1990)). Moreover,there is s description as follows in the study where preparation with o- isomer content rate of less than 9% was orally administered to rats, "Dose independency was observed in the increase of sperm morphology abnormalities and the number of females giving birth to live pups markedly decreased. Although the number of child animals per litter and their survival capability decreased, no effect on the generation was observed (EHC 110 (1990)), and after thorough review of the primary literature (Toxicology, 46 (1987)), it was classified in Category 1B, since there is a description as follows, "Neither of female and male parent animals showed clinical symptoms and body weight decrease."
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		As for the human case, there is a description that "the recovery takes time because it is easily changed from the muscle weakness of the leg to significant paralysis. Although axonal degeneration is seen histopathologically, the individual difference is large" (EHC 110 (1990)), therefore, it classified into Category 1 (nervous systems). In addition, there is no animal data for this article (isomer mixture). The single-dose oral administration test on o-isomer with the strongest toxicity which employed rats has a description that "the degeneration of the spinal cords was seen" within the limits of the guidance value of Category 2 (EHC 110 (1990)).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system), Category 2 (adrenal gland) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (nervous system)
H373: May cause damage to organs through prolonged or repeated exposure (adrenal gland) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		As an impact on human, there is a description of "The occurring case of the laborers who became permanent paralysis of the legs at the manufacturing plant of this substance (less than 1% of o-isomer) has been reported, and 6-10% of o-isomer had been exposed to him at the manufacturing process."( MOE Risk Assessment, Volume 4 (2005)). For animals, although there is a description of "Authors concluded that hazard was low in the short term since the impact was not seen histopathologically" in the three months oral administration test employing rats by the pharmacy which hardly contains o-isomer (EHC 110 (1990)), it has been described that, in the test where this substance containing 1% o-isomer was administered orally for 13 weeks forcibly or administered with feed to the rat, "the cytoplasmic vacuolization of the adkidney adrenal gland were seen dose-dependently" in both cases. (NTP TR433 (1994)) and the impact on the adrenal gland were seen within the range of guidance of Category 2. Although it was thought that the hazard varied greatly depending on the content of o-isomer, priority was given to the the human case exposed to 6-10% of o-isomer for the nervous system, and it was classified into Category 1 (nervous system) and Category 2 (adrenal gland).
10 Aspiration hazard Classification not possible - - - - The kinematic viscosity of the substance is 60 cSt (25degC) and 4.0 cSt (100degC) (EHC 110 (1990)). Therefore, although the kinematic viscosity at 40C falls within the range of >4.0 mm2/s to <60 mm2/s range, the classification is not possible since there is the guidance value between the range.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=0.15mg/L of the fish (Bluegill) (MOE Risk Assessment (2003)).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Although acute toxicity was Category 1, since there were rapid degradability (Existing Chemical Safety Inspections Data (1977)) and bio-accumulation was low (BCF=165 (MOE Risk Assessment (2003))), it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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