GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：4-(1,3-benzothiazol-2-yldisulfanyl)morpholine
CAS：95-32-9
Result：
| ID: | 1-454 |
| Classifier: | Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE） |
| Year Classified: | FY2008 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （Sep, 2008） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid |
| 7 | Flammable solids | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included. |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | The organic compound not including peroxy group in molecule. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | From LD50 value >2,000 mg/kg (Health, Labor and Welfare Ministry report (Access on October 2008)) of the acute oral toxicity test (OECD TG 401, GLP) employing a rat, it was classified into "Not classified". |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable". |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | Classification is not possible since there is no data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | Classification is not possible since there is no data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Although there is description of "positive" in the in vitro mutagenicity test (chromosome aberration test using a Chinese hamster culture cells (CHL/IU) (OECD TG473, GLP)) (Health, Labor and Welfare Ministry reports (Access on October 2008)), classification is not possible because there is no data of in vivo examination. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | There is a report that "reproductive/developmental toxicity effects attributable to the administration of the substance in parents and their offspring were not observed until the highest dose of 1,000 mg/kg " in an reproductive/developmental toxicity screening oral administration test (OECD TG421, GLP) in rats (Ministry of Health, Labor and Welfare Report (Access on October 2008)). However, in this study the data on teratogenicity in the offspring is insufficient. Since there is no other experimental data, classification is not possible. |
| 8 | Specific target organ toxicity - Single exposure | Not classified | - | - | - | - | There is a description of "Abnormalities were not seen in the general state and autopsy finding even if 2,000 mg/kg was administrated in male and female" in the acute oral toxicity test employing rats (OECD TG 401, GLP) (Health, Labor and Welfare Ministry reports (Access on October 2008)). As mentioned above, it was classified into "Not classified ". |
| 9 | Specific target organ toxicity - Repeated exposure | Not classified | - | - | - | - | It is written in 28-day repeated oral administration test in rats (OECD TG407, GLP) that" there were no changes resulting from administration in behavioral function (FOB), sensory response, grip strength, motor activity, urine test, hematologic test, biochemical exam of blood, autopsy, and histological examination by administration of up to 1,000 mg/kg (90-day equivalent: 311 mg/kg) (Ministry of Health, Labour and Welfare reports (Access on October 2008)). As mentioned above, it was classified into "Not classified ". |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 96 hours LC50=0.49mg/L of the fish (Oryzias Latipes) (MOE eco-toxicity tests of chemicals (2002)). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Since acute toxicity was Category 1 and there were no rapid degradability (BIOWIN), it was classified into Category 1. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |