GHS Classification Result

Chemical Name:2-Hydroperoxy-2-phenylpropane
CAS:80-15-9

Result:
ID: 1-440
Classifier: Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Although the peroxide group is included in chemical structure, since the calculation value of oxygen balance was -231 it was classified into Not classified.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Since the flash point by NFPA (13th,2002) is 79degC, it was classified into Category 4.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not applicable - - - - Organic peroxide
9 Pyrophoric liquids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 380degC (IUCLID,2000)).
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Classification not possible - - - - Classification not possible due to lack of data
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Type E Warning H242: Heating may cause a fire P411+P235: Store at temperatures not exceeding ... degC/... degF. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P234: Keep only in original container.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P410: Protect from sunlight.
P420: Store away from other materials.
P501: Dispose of contents/container to ...
It was classified into Class 5.2 and Type E in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.3107(ICSC, 2005)).
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
It was classified into Category 4 from LD50 value 382 mg/kg (DFGOT vol.3 (1992), Patty (5th, 2001), IUCLID (2000)) of the oral administration test employing a rat. In EU classification, Xn; R21/22 (EU-Annex I).
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
There is LD50 value 0.5-1.0 mL/kg of dermal administration test employing rats as information other than List1 (equivalent 530-1,060 mg/kg) (HSDB (2002)), and it classified into Category 3 from low value of 530 mg/kg. Data of unknown animal species includes LD50 value >200 mg/kg (Patty (5th, 2001)). In EU classification, Xn; R21/22 (EU-Annex I).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Dusts and mists) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Saturated vapor pressure level of this substance at 25degC is 4 ppm. Since LC50 value of the 4-hour inhalation exposure test employing rats is 220 ppm (Patty (5th, 2001), IUCLID (2000)), equivalent is 1.4 mg/L by applying the mist standard, and it was classified into Category 4.
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
It has been described that "severe irritation and damages" (DFGOT vol.3 (1992)) were observed in the skin irritation test with rabbits, and that serious erythema, dropsy, and blister formation within 2 or 3 days without immediate effect were indicated in its primary literature (Am. Ind. Hyg. Assoc. J. 19 (1958)). Moreover, it was classified as Category 1 since the decision of IUCLID (2000) to this data was corrosive. It can be classified as C in the EU classification; R34 (EU-Annex I).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
There is a description of "severe irritation and damage" (DFGOT vol.3 (1992)) in the eye irritation test employing rabbits, and in the primary literature (Am.Ind.Hyg.Assoc.J.19 (1958)), it has been described as "Dropping of high concentrated solution into the eyes of rabbits will affect the cornea, the iris, and the conjunctiva greatly." On the other hand, the judgment of IUCLID (2000) to this data was "highly irritating", and since the evaluation was divided, it was classified into Category 1 on the basis of skin type 1.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Classification is not possible since it has only been described that "it has been known to have a skin sensitizing potential " as human toxicity (HSDB (2002)) with no data in the source of information of List1.
5 Germ cell mutagenicity Not classified - - - - Since there are descriptions that a body cell in vivo mutagenicity test (micronucleus tests which employs mouse erythrocyte) was "negative" (NTP DB (Access on September 2008)), and the productive cell in vivo administration cost mutagenicity test (dominant lethal tests) which employs mice for the source of information of List2 was "negative" (HSDB (2002)), it was classified into "Not classified."
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made, classification is not possible. In addition, DFGOT vol.3 (1992) have a description that "the tumor initiation effect of Hydroperoxide cannot be disregarded at all at present, however a potential of not showing an initiation effect is high".
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system) Warning H371: May cause damage to organs (respiratory system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
There is a description of "Critical inflammations in airway and lungs were seen by necropsy in the test where the lethal dose is found" in the vapor inhalation exposure test employing rats (Patty (5th, 2001)), and LD50 value is 382 mg/kg. The paragraph of the effects of short term exposures of ICSC (2005) of List.3 has described as "It shows corrosion behavior to a respiratory tract.... Inhalation of it may cause lung oedema." Although the lung oedema case in humans was not identified by search in the literature, since the lung influence at neighborhood LD50 value of an animal was equivalent to guidance value within the range of Category 2, it was classified into Category 2 (respiratory system).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - It is written in repeated oral administration test in rats (for seven weeks, 3 times/week) that "cystinotic effects occurred" (Patty (5th, 2001)), etc. Although effects were found within the scope of the guidance value of Category 2, as a result of scrutinizing primary literature (Am.Ind.Hyg.Assoc.J.19 (1958)), clear effects were not obtained besides "weight loss, and decreased weight gains." Therefore, since data is insufficient, classification is not possible.
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 96 hours LC50=3.9mg/L of the fish (Rainbow Trout) (IUCLID (2000)).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 2 and there were no rapid degradability (not readily degradable, the decomposition by BOD(standard test method (4 weeks)): 0% (Existing Chemical Safety Inspections Data (2004)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

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Model SDS by MHLW

MHLW Website (in Japanese Only)


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