GHS Classification Result

Chemical Name：3-(Methylsulfanyl)propanal
CAS：3268-49-3

Result：
ID: 1-437
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since the flash point by IUCLID(2000) is 63degC(closed type), it was classified into Category 4.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 255degC (ICSC,1997)).
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		From LD50 value 490 mg/kg (male), 1,050 mg/kg (female) (SIDS (2003)) of the acute oral toxicity test (OECD TG 401, GLP) employing a rat, it was classified into Category 4.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Among LD50 value with 2,631 mg/kg (SIDS (2003)) of the dermal administration test employing rats (OECD TG 402), and LD50 value with 748-1,700 mg (SIDS (2003)) of the dermal administration test employing rabbits (OECD TG 402), it was classified into Category 3 from 748 mg/kg whose test year was new, and value was low.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is written that LC50 values are 1,036-1,105 ppm (male) and >1,105 ppm (female) in 4-hour inhalation exposure test employing rats (OECD TG 403, GLP) (SIDS (2003)), LC50 value is judged to be 1,036-1,105 ppm in SIDS (2003). Since saturated vapor pressure level of this substance (20degC)is 1,970 ppm, it was classified into Category 3 by applying the gas standard.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		A result of "slight irritation" and that of "necrosis" are described in SIDS (2003) for the 4-hour skin irritation test using rabbits. Since SIDS (2003) has drawn a conclusion, "There is skin irritation," based on many experimental results including these, it was classified in Category 2.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Since in SIDS (2003), there is a description of "The conjunctival edema which was not recovered during the observation and the corneal opacity were seen" in the eye irritation/corrosion test employing rabbits (OECD TG 405) and SIDS (2003) has concluded as "It causes irreversibly damage" based on this experiment result, it was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		It was classified as Category 1 since it was described as "skin sensitizing potential" SIDS (2003) in the Maximization tests (OECD TG406) employing guinea pig by GLP and non-GLP, and it was concluded as "mild skin sensitizing" in SIDS (2003).
5 Germ cell mutagenicity Not classified - - - - From a description of "negative" (SIDS (2003)) in the body cell in vivo mutagenicity test (micronucleus test employing a mouse) (OECD TG 474, GLP), it was classified into "Not classified".
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - There are descriptions as follows in SIDS (2003), "No effect was found on genital organs" in the 28 day oral administration study using rats and "No effect was found on reproductive organs" in the 9 day inhalation exposure test using male and female rats. Moreover, there is a description as follows, "No effect has been found on implantation, embryos and fetuses at the dose level where reduction in mother animals' body weight and food consumptions, " in the pre-birth developmental toxicity study (OECD TG 414, GLP). Since there is no data, however, for the effect on reproductive organs and post-birth children, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 1／2 (systemic toxicity) Danger H370: Causes damage to organs (systemic toxicity) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there were descriptions of "breathing difficulty, nasal mucus, crackle, ataxia, and locomotor activity reduction" (SIDS (2003)) in the acute oral toxicity test employing rats (OECD TG 401, GLP) and "locomotor activity reduction and ataxia" (SIDS (2003)) in the dermal administration test employing rabbits (OECD TG 402), since the dose was unknown, it classified into Category 1/2 (systemic toxicity).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, central nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, central nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It is written in 28-day oral administration test in rats (OECD TG 407) that" there were decrease in the number of red blood cells, fall in hemoglobin level, increase in bilirubin, and deposition of pigment and blood to red pulp in the histopathological examination in males and females of 521 mg/kg (90-day equivalent : 162 mg/kg) group, and slight increase in creatinine in males of 104 mg/kg and 521 mg/kg groups" (SIDS (2003)), and it is concluded in SIDS (2003) that" 521 mg/kg group occurs slight hemolyzing property NOAEL: 104 mg/kg". Moreover, it is written in 21-day dermal administration test in rats that "there were no hematological, biochemical, and histological changes by administration of up to 1,650 mg/kg" (IUCLID (2000)). On the other hand, in 100- day inhalation exposure test in rats, " effects on redox function of liver (decrease in oxygen demand, decrease in catalase activity, and decrease in blood lactic acid and pyruvic acid), and central nervous system effect" (IUCLID (2000)) correspond to Category 1by judging from the guidance value, however, it was classified into Category 2 (liver, and central nervous system) according to this guidance, since it is data of List2, and does not comply with the acceptance criteria 1b3).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 72 hours EC50=0.99mg/L of the algae (Pseudokirchneriella subcapitata) (MOE eco-toxicity tests of chemicals (1998)).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Although acute toxicity was Category 1, since there were rapid degradability (the decomposition by DOC: 92% (SIDS (2005))) and there were no bio-accumulation (Logk=0.34 (IUCLID (2000))), it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information