GHS Classification Result

Chemical Name：Benzophenone
CAS：119-61-9

Result：
ID: 1-403
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Classification not possible - - - - Classification not possible due to lack of data
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		From a description of LD50 value 1,900 mg/kg of the oral administration test employing a rat (NTP TR533 (2006)) and LD50 value 1,600 mg/kg of the oral administration test employing a mouse (Patty (5th, 2001)), LD50 value 1,900 mg/kg of a rat was adopted and it was classified into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - From a description of LD50 value of 3,535 mg/kg (NTP TR533 (2006)) in the dermal administration test employing rabbits, it was classified into "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - There have been descriptions of "slight irritation" and "erythema, desquamation, and slight to moderate edema" in the patch tests for 24 hours employing guinea pig (Patty (5th, 2001)) and "slight irritation" in the Draize tests in which 20% solution was applied to rabbits for 24 hours (IUCLID (2000)). Moreover, it has been described that "slight to medium edema with dyskeratosis and local necrosis occurred, and medium irritation was shown with 2.0 of skin irritation index" in the test in which crack skin of rabbits was treated with 20% solution (Patty (5th, 2001)). Classification is not possible because of inadequate data.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Slight to moderate redness occurred in crystallographic droppings test to eyes of rabbits in the conjunctiva and the nictitating membrane from 1 hour to 24 hours. From the description of "Slight redness was seen in one of three rabbits till 48 hours and all the eyes became normal 14 days after."(Patty (5th, 2001)), it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Not classified - - - - It was classified into "Not classified" from description of "no sensitizing potential" in the skin sensitization tests employing guinea pig (the Open Epicutaneous test, Maximization test, Draize test, and Freund's Complete Adjuvant test) (Patty (5th, 2001)).
5 Germ cell mutagenicity Not classified - - - - It was classified into "Not classified" based on a statement that the in vivo mutagenicity test using a somatic (micronucleus tests which employs the erythrocyte of a mouse) was "negative" (NTP DB (Access on September 2008)).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is a description that "tubular adenoma and leukemia broke out" in the oral administration test for two years employing a rat (NTP DB (Access on September 2008)) and another description that "liver cell cancer and sarcoma occurred" in the oral study for two years employing a mouse (NTP DB (Access on September 2008)). Since NTP DB (Access on September 2008) concluded that "there is a certain amount of evidence that this article causes oncogenesis in male rats and male and female mice, and an ambiguous evidence that it causes oncogenesis in female rats", it was classified into Category 2. In addition, no evaluation by major international evaluation agencies is made.
7 Reproductive toxicity Not classified - - - - There are descriptions as follows, "There was no effect on the survival capacity after birth or development ratio of overall deformation and mutation among fetuses" (NTP DB (Access on September 2008)) at the dose level where liver and kidney weight of mother animals increasesd in the repeated oral administration test applied to rats of 6-19 day pregnancy and " Changes related to this substance were not found in estrogen cycles, reproductive capability, child-birth, breast-feeding, sperm parameters, serum hormones or expressions of necrosis but suppression of the body weight increase among male child animals was observed. No effect was found among male and female child animals on the number of child-birth, survival capability, anogenital distances"at the dose level where suppression of the body weight increase with mother animals was observed, in the 2 generation repetitive oral administration study with rats" (HSDB (2007). Moreover, there is a description as follows in the repetitive oral administration study with rats of 6-29 day pregnancy, "Although dose dependent reduction in the average body weight of fetuses per 1 litter was observed, no change was found in the pre-birth survival rate, fetal deformation or mutation. Although dose dependent death of mother animals, premature birth and miscarriage were found, there were administration mistakes and deviations in animal species in these dose groups" (NTP DB (Access on September 2008). Therefore, premature birth and miscarriage recognized at the dose level where death among mother animals was recognized in the study using rabbits were not adopted for the decision making due to the possibility of secondary effects and it was classified into "Not classified", judged from other study results.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Classification is not possible as there is no data. In addition, there is a description of "pharyngitis" (ICSC (1997)) as an acute toxicity condition at the time of inhalation.
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, kidney, blood system, bone marrow) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney, blood system, bone marrow) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It is written in 2-year repeated oral administration test in rats and mice that" nephropathia increased in male rats and male and female mice, " "centrolobular hypertrophy of hepatocytes increased in male and female rats and mice, and multinuclearity and chronic inflammation of hepatocytes also increased in male and female mice", "hyperplasia of lymphatic follicle of lien significantly increased" and "myelofibrosis was found in 30 mg/kg dose groups and 60 mg/kg dose groups in male and female rats" (NTP TR 533 (2006)). Moreover, it is written in 28-day repeated oral administration test in rats that "cythemolysis, serum albumin, and kidney weight increased in female rats (Patty (5th, 2001)), and "the number of red blood cells, hemoglobin, hematocrit level, and bilirubin, etc. changed in relation to administration "about the same test in HSDB (2007). All these effects were found within the scope of the guidance value of Category 2. Therefore, it was classified into Category 2 (liver, kidney, blood system, and bone marrow).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 72 hours EC50=3.5mg/L of the algae (Pseudokirchneriella subcapitata) (Environmental Agency eco-toxicity tests of chemicals (1998)).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 2 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 0% (Existing Chemical Safety Inspections Data (1980)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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