GHS Classification Result

Chemical Name:Diammonium peroxydisulfate
CAS:7727-54-0

Result:
ID: 1-395-2)
Classifier: Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Although the "adjacent oxygen atom" associated with explosive properties is included, it was classified into Not classified because it was classified into Class 5.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1444(ICSC, 2001)).
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Not classified - - - - Since it was classified into Class 5.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1444(ICSC, 2001)), it was classified into Not classified.
8 Self-reactive substances and mixtures Not classified - - - - Although the "adjacent oxygen atom" associated with explosive properties is included, it was classified into Not classified because it was classified into Class 5.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1444(ICSC, 2001)).
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Non-combustible inorganic compounds.
11 Self-heating substances and mixtures Not classified - - - - Non-combustible inorganic compounds.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Category 3 Warning H272: May intensity fire; oxidizer P370+P378: In case of fire: Use ... for extinction.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P221: Take any precaution to avoid mixing with combustibles/...
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Since it was classified into Class 5.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1444(ICSC, 2001)), it was classified into Category 3.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
It was classified into Category 4 from LD50 value of 495 mg/kg (female) (SIDS (2005), NICNAS (2001), IUCLID (2000)) of the oral administration test employing a rat (OECD TG 401, GLP). In addition, in EU classification, it is Xn; R22 (EU-Annex I) and is equivalent to Category 3-4.
1 Acute toxicity (Dermal) Not classified - - - - Since LD50 value of the dermal administration test employing rats (OECD TG 402, GLP) was >2,000 mg/kg (SIDS (2005), NICNAS (2001), IUCLID (2000)), it was classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - LC50 value of 4-hour inhalation exposure test employing rats (OECD TG 403, GLP) is >2.95 mg/L (SIDS (2005), NICNAS (2001), IUCLID (2000)). When applying the dust standard due to a solid, classification cannot be specified, classification is not possible.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
For animals, the descriptions of "zero of mean score value of erythema/ edema" (SIDS (2005)) and "edema having disappeared within 24 hours (NICNAS (2001)) have been shown in a 4-hour skin irritation/corrosion test in which non-diluted solution was applied to rabbits (OECD TG 404, GLP). For humans, "irritative" has been described in either the patch test in which a 5% solution of the substance was applied, or the test in which a 17.5% solution of the substance was applied for 4 hours (SIDS (2005)). SIDS (2005) has described "slightly irritating" for rabbits and "can cause skin irritation" in a 5% or more solution of the substance for humans as a conclusion. Therefore, it was classified into Category 2. In addition, it can be classified as Xi in the EU classification; R36/ 37/ 38 (EU-Annex I), being equivalent to Category 2-3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
For animals, there is a description of "The symptom of conjunctivitis was observed for 48 hours after application in slight to mild."(SIDS (2005)) in Draize test employing rabbits (OECD TG 405, GLP). Moreover, for the same test, there is also a description "The author of the literature has concluded that "This substance has eye irritation from the test result where conjunctivitis and iritis were observed in slight to mild."(NICNAS (2001)). As mentioned above, it was classified into Category 2B. In addition, the EU classification is Xi; R36/37/38 (EU-Annex I), and is equivalent to Category 2.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ...
For humans, it has been described that "2, 3, and 3 of 52 persons of manufacturing factory employees were positive to this substance alone, the related substance of Peroxydisulfuric acid dipotassium salt (CAS No.7727-21-1, hereinafter described as dipotassium salt) alone, and both of this substance and dipotassium salt, respectively. The correlation trend was indicated between positive results and slight decrease of lung function." in vivo immunological test (skin prick test) (SIDS (2005)). Moreover, there is also a report of occupational asthma in beauticians, and it has been concluded that "test results in humans show that the substance is a respiratory sensitizer in occupational exposure"in SIDS (2005). As mentioned above, it was classified into Category 1. In addition, it can be classified as Xi; R42/43 (EU-Annex I) in the EU classifications, which is equivalent to Category 1. Moreover, it can be displayed as Sah (ACGIH-TLV/BEI (2005)) in the German MAK list.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
About animals, it has been described that "it is suspicious since all of 20 animals were positive in hypodermic although being negative in dermal" (SIDS (2005)) in the maximization test with 20 guinea pig (OECD TG 406). About humans, it has been described that "12 of 49 beauticians were positive" in the patch test (SIDS (2005)), and it has also been described that "eczema, skin diseases, and pimples were developed" (SIDS (2005)) or that "allergic dermatitis was observed" (NICNAS (2001)) as occupational exposures in beauticians. It has been concluded that "test results in humans show that the substance is a skin sensitizer in occupational exposure" in SIDS (2005). As mentioned above, it was classified into Category 1. In addition, it can be classified as Xi; R42/43 (EU-Annex I) in the EU classifications, which is equivalent to Category 1. Moreover, it can be displayed as Sah (ACGIH-TLV/BEI (2005)) in the German MAK list.
5 Germ cell mutagenicity Classification not possible - - - - Although there is a description of "negative" (SIDS (2005) and NICNAS (2001)), respectively in the in vitro mutagenicity test (chromosome aberration test employing Chinese hamster ovaria fibroblasts and the Ames test employing a Salmonella typhimurium and bacillus coli), classification is not possible because there is no data of in vivo examination. In addition, there is a description of "negative" in the in vivo mutagenicity test (micronucleus test employing mouse erythrocyte) and in the in vivo genotoxicity test (UDS test using rat hepatocytes), respectively, for Disodium peroxydisulfate (CAS No.7775-27-1) which is a substance (SIDS (2005), NICNAS (2001)).
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no sufficient data, classification is not possible. In addition, the dermal administration test for 51 weeks employing female mice has a description that "there is no skin cancers promoter activity in this substance" (SIDS (2005)), and another description that "there is data of the skin cancer formation resulting from this substance, however, the size of study groups was small and dosing regimens didn't meet the guideline, therefore final conclusions cannot be drawn" (NICNAS (2001)).
7 Reproductive toxicity Classification not possible - - - - It is reported that "no effects on fertility, fertility rate, fetal abnormality, fetal survival, sperm formation and spermatogenic cycle were observed until the highest dose of 250 mg/kg" (SIDS (2005)) in a reproductive/developmental toxicity screening study in rats (OECD TG 421, GLP). However, in this study the data on teratogenicity in the offspring is insufficient. Since there is no other experimental data, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system), Category 3 (respiratory tract irritation) Warning H371: May cause damage to organs (central nervous system)
H335: May cause respiratory irritation (respiratory tract irritation)
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
In the oral administration test employing rats (OECD TG 401, GLP), "nerve tremor, salivation, dacryorrhea, paleness, locomotor activity reduction, and ataxia were observed. There is a description of "These symptoms have recovered within five days in living animals."(SIDS (2005)). This impact was seen within the limits of the guidance value of Category 2. Moreover, there is a description of "Respiratory distress was seen" in 4-hours inhalation exposure test employing rats (GLP) (SIDS (2005)). There is a description that, as a conclusion, "This substance shows Respiratory tract irritation in occupational exposure."(SIDS (2005)). As mentioned above, it was classified into Category 2 (central nervous system) and Category 3 (Respiratory tract irritation). In addition, ICSC (2001) has described that "Effect of short term exposure. : ... It irritates the respiratory tract. Inhalation of dust may cause an asthmatic reaction.
9 Specific target organ toxicity - Repeated exposure Category 2 (respiratory system) Warning H373: May cause damage to organs through prolonged or repeated exposure (respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In animal case, in the 13-week inhalation exposure test to rats (OECD TG 413, GLP), "an increase in rale and rapid respiration" (SIDS (2005)) were observed in female rats within the limits of the guidance value of Category 1, and "an increase in hemoglobin value and hematocrit value, inflammation in the airway in female rats, an increase in rale, rapid respiration, weight reduction, decreased weight gains, feed intake reduction, an increase in the relative and absolute lung weight, an increase in relative brain weight, inflammation in the airway, excessive mucus secretion in the bronchi and, as a serious symptom, alveolar histiocytosis were observed in male and female rats" (SIDS (2005)) within the limits of the guidance value of Category 2Therefore, it is classified into Category 2 (respiratory systems). In addition, ICSC (2001) shows that "effects of long term or repeated exposure: repeated or prolonged inhalation exposure may cause asthma."
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 3 from 96 hours EC50=33mg/L of the algae (Scenedesmus) (AQUIRE (2008)).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Although it was considered to be toxicity factor that aqueous solution changed as a strong base, toxic effect was eased by the buffer action in the environmental water, it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

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