Chemical Name:Dipotassium peroxydisulfate
CAS:7727-21-1
ID: | 1-395-1) |
Classifier: | Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE) |
Year Classified: | FY2008 |
Reference Manual: | GHS Classification Guidance by the Japanese Government (Sep, 2008) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not classified | - | - | - | - | Although the "adjacent oxygen atom" associated with explosive properties is included, it was classified into Not classified because it was classified into Class 5.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1492(ICSC, 2002)). |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid |
7 | Flammable solids | Not classified | - | - | - | - | Although the "adjacent oxygen atom" associated with explosive properties is included, it was classified into Not classified because it was classified into Class 5.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1492(ICSC, 2002)). |
8 | Self-reactive substances and mixtures | Not classified | - | - | - | - | Although the "adjacent oxygen atom" associated with explosive properties is included, it was classified into Not classified because it was classified into Class 5.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1492(ICSC, 2002)). |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid |
10 | Pyrophoric solids | Not classified | - | - | - | - | Non-combustible inorganic compounds. |
11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Non-combustible inorganic compounds. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included. |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid |
14 | Oxidizing solids | Category 3 | Warning | H272: May intensity fire; oxidizer |
P370+P378: In case of fire: Use ... for extinction. P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking. P220: Keep/Store away from clothing/.../combustible materials. P221: Take any precaution to avoid mixing with combustibles/... P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Since it was classified into Class 5.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1492(ICSC, 2002)), it was classified into Category 3. | |
15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic compound |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
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1 | Acute toxicity (Oral) | Category 4 | Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
It was classified into Category 4 from LD50 value 1,130 mg/kg (male) (SIDS (2005), NICNAS (2001), IUCLID (2000)) of the oral administration test employing a rat. In addition, in EU classification, it is Xn; R22 (EU-Annex I) and is equivalent to Category 3-4. | |
1 | Acute toxicity (Dermal) | Not classified | - | - | - | - | Since LD50 value of the dermal administration test employing rats was >10,000 mg/kg (SIDS (2005), NICNAS (2001)), it was classified into "Not classified". |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable". |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified | - | - | - | - | Since it is written that LC50 value of 1-hour inhalation exposure test employing rats is >42.9 mg/L (SIDS (2005), IUCLID (2000)), 4-hour equivalent LC50 value is >10.7 mg/L when applying the dust standard due to a solid. Therefore, it was classified into "Not classified". |
2 | Skin corrosion/irritation | Category 2 | Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P362: Take off contaminated clothing and wash before reuse. |
For animals, although "not irritating" has been described in the skin irritation test with rabbits (SIDS (2005)), the details including exposure time are unknown. For humans, there is a description of "irritative" in the test in which a 17.5% solution of this substance was applied for 4 hours (SIDS (2005)). For humans, SIDS (2005) has described "can cause skin irritation" in 5% or more solution of this substance as a conclusion. Therefore, it was classified into Category 2. In addition, it can be classified as Xi in the EU classification; R36/ 37/ 38 (EU-Annex I), being equivalent to Category 2-3. | |
3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | For animals, there is a description of "It is the eye irritation test employing eight rabbits and any of average score value in the cornea, the iris, and the conjunctiva is 0."(SIDS (2005)). Moreover, in NICNAS (2001), there is a description of "marginal irritation to rabbit eyes" about the same test. Furthermore, although SIDS (2005) has a description of "Peroxydisulfuric are harmful to human eyes", since other data cannot be found, classification is not possible due to insufficient data. In addition, the EU classification is Xi; R36/37/38 (EU-Annex I), and is equivalent to Category 2. |
4 | Respiratory sensitization | Category 1 | Danger | H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled |
P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ... |
For humans, it has been described that "2, 3, and 3 of 52 persons of manufacturing factory employees were positive to this substance alone, the related substance of Diammonium salt (CAS No.7727-54-0) alone, and both of this substance and Diammonium salt, respectively. The correlation trend was indicated between positive results and slight decrease of lung function." in vivo immunological test (skin prick test) (SIDS (2005)). Moreover, there is also a report of occupational asthma in beauticians, and it has been concluded that "test results in humans show that the substance is a respiratory sensitizer in occupational exposure"in SIDS (2005). As mentioned above, it was classified into Category 1. In addition, it can be classified as Xi; R42/43 (EU-Annex I) in the EU classifications, which is equivalent to Category 1. | |
4 | Skin sensitization | Category 1 | Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
For humans, it has been described in SIDS (2005) that there are two positive reports including one in study auxiliary service and another in beauticians in the patch test to which a 2.5% solution of the substance was applied. Moreover, about the relative substance of diammonium salt (CAS No.7727-54-0), it has been described that "eczema, skin diseases, and pimples were developed" (SIDS (2005)) or that "allergic dermatitis was observed" (NICNAS (2001)) as occupational exposures in beauticians, and it has been concluded that "test results in humans show that the substance is a skin sensitizer in occupational exposure" in SIDS (2005). As mentioned above, it was classified into Category 1. In addition, it can be classified as Xi; R42/43 (EU-Annex I) in the EU classifications, which is equivalent to Category 1. | |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Classification is not possible because there is no data. In addition, there is a description of "negative" in the in vivo mutagenicity test (micronucleus test employing mouse erythrocyte) and in the in vivo genotoxicity test (UDS test using rat hepatocytes), respectively, for Disodium peroxydisulfate (CAS No.7775-27-1) which is a substance (SIDS (2005), NICNAS (2001)). |
6 | Carcinogenicity | Classification not possible | - | - | - | - | Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible. In addition, it is recommended to refer also to the category result of the Diammonium salt (CAS No.7727-54-0) which is a relative substance. |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | Classification is not possible because there is no data. Refer to the classification result of a related substance, Diammonium salt (CAS No.7727-54-0). |
8 | Specific target organ toxicity - Single exposure | Category 2 (systemic toxicity), Category 3 (respiratory tract irritation) | Warning |
H371: May cause damage to organs (systemic toxicity) H335: May cause respiratory irritation (respiratory tract irritation) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
The single-dose studies which calculates oral lethal dose of rats has a description that "a hypoactivity (depression), shallow breathings (weak breathing), and respiratory distress were acknowledged. Such symptoms were recovered within four days in live animals" (SIDS (2005)). This impact was seen within the limits of the guidance value of Category 2. Moreover, there is also a description of "nasal discharges and dyspnea" (SIDS (2005)) as human impacts. As mentioned above, it was classified into Category 2 (systemic toxicity) and Category 3 (Respiratory tract irritation). In addition, it is recommended to also refer to the category result of the Diammonium salt (CAS No.7727-54-0) which is a relative substance. | |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | In the 28-day repeated oral administration test to male rats, there is the description that "no toxic effect was detected" (SIDS (2005)), but the details are unknown because the data is non-public. Since there is no other test data, classification is not possible because of lack of sufficient data. In addition, also refer to the classification result of the related substance, Diammonium salt (CAS No.7727-54-0). |
10 | Aspiration hazard | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 3 from 48 hours LC50=92mg/L of the crustacea (Daphnia magna) (AQUIRE (2008)). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified | - | - | - | - | Although it was considered to be toxicity factor that aqueous solution changed as a strong base, toxic effect was eased by the buffer action in the environmental water, it was classified into Not classified. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |