GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Hexadecan-1-yl(trimethyl)ammonium chloride
CAS：112-02-7
Result：
| ID: | 1-389 |
| Classifier: | Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE） |
| Year Classified: | FY2008 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （Sep, 2008） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid |
| 7 | Flammable solids | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included. |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Although it is an organic compound including not oxygen and fluorine but chlorine, since the chlorine was included as ammonium salt, it was classified into "Not applicable". |
| 15 | Organic peroxides | Not applicable | - | - | - | - | The organic compound not including peroxy group in molecule. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
It classified into Category 4 from least fatal dose of 400 mg/kg (RTECS (1999)) of the oral administration test employing a mouse, and 400 mg/kg |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | It is described as LD50 value 4.3 mL/kg (equivalent: 4,162 mg/kg) (RTECS (1999), USCh (2001)) of the oral administration test employing a rabbit. Although this LD50 value corresponded to the U.N. GHS acute toxicity Category 5, it fell under unadopted category in Japan and was classified into "Not classified". |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable". |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
It was classified into Category 2 from the descriptions of skin irritation of liquid of the substance (HSDB (2003)) and tissue damages in human (GESTIS (Access on October 2008)). |
| 3 | Serious eye damage/eye irritation | Category 2 |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
From the description that, in humans, the steam and the liquid of this substance have eye irritation (HSDB (2003)) and the damages, such as corneal opacity and conjunctiva dropsy are found (GESTIS (Access on October 2008)), it was classified into Category 2. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | Classification is not possible since there is no data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | Classification is not possible since there is no data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Although it is described as negative (HSDB (2003), USCh (2001)) in the reverse mutation test employing in vitro bacteria, classification is not possible because there is no data of in vivo examination. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | Since there is no data, and no evaluation of major international evaluation agencies such as IARC is made, classification is not possible. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Although it is described in the dermal administration test (GLP) using rabbits of 7-18 day pregnancy that no effect on mother animals other than skin irritation are observed nor fetal toxicity (USCh (2001)), classification is not possible due to insufficiency of data, because it was the study at a low dose rate of 40mg/kg. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Respiratory tract irritation） |
|
Warning | H335: May cause respiratory irritation (respiratory tract irritation) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
It was classified into Category 3 (Respiratory tract irritation) based on a description that human exposure to vapor causes Respiratory tract irritation (HSDB (2003)). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | In a 20-day dermal administration test with rabbits (GLP), it was reported that at a dose of 10 mg/kg no toxicity was observed apart from skin irritation (USCh (2001)). A dose of 10 mg/kg is within the range of guidance values for Category 1, and since there is no experimental data with higher does or longer periods, classification is not possible. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 48 hours EC50=0.01mg/L of the crustacea (Daphnia magna) (AQUIRE (2008)). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Since acute toxicity was Category 1 and there were no rapid degradability (BIOWIN), it was classified into Category 1. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |