GHS Classification Result

Chemical Name：Hexane-1,6-diyl diacrylate
CAS：13048-33-4

Result：
ID: 1-306
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Not classified - - - - Since the flash point by OSHA(2004) is 132degC(Cleveland Open-cup Tester), it was classified into Not classified.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Classification not possible - - - - Although the unsaturated bond is included in chemical structure, classification is not possible with no data.
9 Pyrophoric liquids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 235degC (OSHA, 2004)).
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Although LD50 value 5,000 mg/kg of the oral administration test employing a rat (HSDB (2004)) corresponded to the U.N. GHS acute toxicity Category 5, it fell under unadopted category in Japan and was classified into "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Although LD50 value with 3,600 mg/kg (HSDB (2004)) of the dermal administration test employing rats corresponds to the U.N. GHS acute toxicity Category 5, it was classified into "Not classified" since it was rejected classification at home.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - Although it has been described that there is a possibility of irritant dermatitis in humans (HSDB (2004)), the expression time of the symptom is unknown. Moreover, although "severe" irritation with a 24-hour application in rabbits (RTECS (2003)) has been described, irritation with a 4-hour application is unknown. Therefore, classification is not possible. European Union classification Xi; R36/ 38 (EU-Annex I) are equivalent to Category 2.
3 Serious eye damage/eye irritation Classification not possible - - - - Although EU classification Xi; R36/38 (EU-Annex I) is equivalent to Category 2, since there is no other information, classification is not possible.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		It was classified as Category 1 from description that it was a German MAK list Sensitisation substance (Sh) (ACGIH-TLV/BEI (2005)), and allergic dermatitis among the printing industry workers and sensitizing potential at the resin paint factory were observed through a cotact to this substance (HSDB (2004)). It can be classified as R43 (EU-AnnexI) in the EU classification, which is equivalent to Category 1.
5 Germ cell mutagenicity Classification not possible - - - - Although it is negative in the genotoxicity test employing in vitro bacteria (NTP DB (Access on September 2008)), classification is not possible because there is no data of in vivo examination.
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made, classification is not possible. In addition, the test administered 50 mg of this article to the skin of mouse for 80 weeks (it is 2 times per week) showed that fibrosarcoma was seen in one out of 50 animals, and it is described that a rate is very small compared with positive control group (HSDB (2004)).
7 Reproductive toxicity Classification not possible - - - - Although in an oral administration study in 6-15 day pregnant rats irritation or white parts in the stomach were observed at doses of 500 mg/kg and urinary stain, rough hair coat, salivation etc. were observed at doses of 1,000 mg/kg in mother animals, no abnormalities were observed in the ovaria or uterus. (HSDB (2004)). Furthermore, in an oral administration study in 6-15 day pregnant rats there is a report of a minimum toxicity value of 7,500 mg/kg (RTECS (2003)), and the effects are at doses far above 1,000 mg/kg. However, since there is no data in the information sources in List 1, classification is not possible.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Although it is described that low molecular weight acrylic ester has mucosa irritation (HSDB (2004)), since it is unknown whether this substance is included or not, classification is not possible.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although it is reported (HSDB (2004)) that congestion of the lungs, bleeding and cloudy swelling of the liver and kidney were observed in laboratory animals when it was administered as acrylic ester, the dosing period and dosage are unknown and the test substance cannot be identified as the substance under discussion, so classification is not possible.
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=0.38mg/L of the fish (Oryzias Latipes) (Environmental Agency eco-toxicity tests of chemicals (1998)).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 1 and there were no data about rapid degradability, it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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