GHS Classification Result

Chemical Name：Tributan-1-ylamine
CAS：102-82-9

Result：
ID: 1-292
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since the flash point by ICSC(2005) is 63degC(closed type), it was classified into Category 4.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 210degC (ICSC,2005)).
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - It is an organic compound not containing oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		LD50 value of the oral administration test employing a rat includes 540 mg/kg (Patty (5th, 2001) and 114 mg/kg (RTECS (2008)).). From LD50 value 540 mg/kg described in the information source of List1, it was classified into Category 4.
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From a description of LD50 value of 250 mu L/kg (equivalent: 195 mg/kg) (Patty (5th, 2001), RTECS (2006)) in the dermal administration test employing rabbits, it was classified into Category 2.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is written that mortality with 75 ppm of exposure level: 4/6 in 4-hour inhalation exposure test employing rats (Patty (5th, 2001), and LC50 value is considered to be <75 ppm. Since saturated vapor pressure level of this substance (25degC)is 122.89 ppm, it was classified into Category 1 by applying the gas standard.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		The irritation of Amines was evaluated as Grade 1-10 in the 24 hour skin irritation test with rabbits and this substance is presumed to be stimulating, because there is a description, "Grade 4" (Patty (5th, 2001)), although it is not a datum of 4-hour exposure. Moreover, since there are descriptions, "It has skin irritation" (Patty (5th, 2001, ICSC (2005)), "burns in the skin" and "stimulating" (HSDB (2002), it was classified in Category 2, although reversibility is not unknown.
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Although there is description that when Grade 1-10 estimates the irritation of amines in the eye irritation test employing rabbits, this substance shows "Grade 1: slight necrosis when 0.5 mLof non-diluted substance is instilled in the eye."(Patty (5th, 2001) effect), the level of irritation is unknown. Moreover, there is a description of "Almost all aliphatic Amins has eye irritation" (Patty (5th, 2001)), "It has serious influence and may cause dacryorrhea, conjunctivitis, and cornea dropsy," "It has irritation" (HSDB (2002)), and "It has a slight irritation."(ICSC (2005)). Although the level of irritation ranges from severe to mild, since this substance was a skin irritation substance, it was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Although there is a description that "skin sensitization is caused" (Patty (5th, 2001), HSDB (2002)), classification is not possible because of unknown details and insufficient data.
5 Germ cell mutagenicity Classification not possible - - - - Classification is not possible because there is no data of in vivo examination. In addition, there is a description of "negative" in the in vitro mutagenicity test (Ames test employing a Salmonella typhimurium) (NTP DB (Access on November 2008)).
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified into Category 3 (Respiratory tract irritation) based on a description that "the lung irritation is deduced from decrease in a breathing rates" by the test which calculates RD50 value (50% breathing rates inhibitory concentrations) in inhalation exposures employing a mouse (HSDB (2002)). In addition, Patty (5th, 2001) has descriptions that aliphatic amines "showed very strong stimulus property and will stimulate mucosa and airway when steamy exposure of the animal is carried out by high concentrations", and that "a single dose in concentrations proximate for deaths causes tracheitis, bronchitis, pneumonia and lung edemas. "Moreover, the oral study on this article using the mammal (species unknown) has a description of "lethargy, agitation" (RTECS (2008)), and another description that "headache, nausea, vomit, dizziness, agitation and convulsion are caused" (HSFS (1999)).
9 Specific target organ toxicity - Repeated exposure Category 2 (central nervous system) Warning H373: May cause damage to organs through prolonged or repeated exposure (central nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the 19-day inhalation exposure test to male and female rats, "nasal irritation, disquiet, incoordination and trembling were observed" (Patty (5th, 2001), HSDB (2002)). Although these symptoms were observed within the limits of the guidance value of Category 1, it was classified into Category 2 (central nervous systems) since the OECD TG compliance and GLP were unknown. Moreover, although there is the description that "tracheitis, bronchitis, pneumonia and lung edema are caused by repeated inhalation exposure to sublethal concentration of aliphatic amines" (Patty (5th, 2001)), it is not adopted to categorize since the period and the concentration of exposure are unknown. In addition, "there are reports of central nervous system irritation" (Patty (5th, 2001) and (HSDB (2002)).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48 hours EC50=8mg/L of the crustacea (Daphnia magna) (AQUIRE (2008)).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 2 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 2% (Existing Chemical Safety Inspections Data (2002)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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