GHS Classification Result

Chemical Name：1,2,3-trichlorobenzene
CAS：87-61-6

Result：
ID: 1-290-2）
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Not classified - - - - Since it was classified into Class 6.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.2321 (HSDB (2008)), it was classified into Not classified.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Since it was classified into Class 6.1 an PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.2321 (HSDB (2008)), it was classified into Not classified.
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - Although it is an organic compound including chlorine, not oxygen and fluorine, chlorine has bound only to carbon.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		There is a description of 1,830 mg/kg (4th volume (2005) of the MOE risk assessment), DFGOT vol.3 (1992), >5,000 mg/kg (DFGOT vol.3 (1992)), and 756 mg/kg (HSDB (2004)) as LD50 value of the oral administration test employing a rat. The category to which multiple data corresponded was adopted and it was classified into Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - There is a description, "There is no irritation,"(DFGOT Vol.3 (1992)) in the 4-hour study where 500mg of this substance was administered into the skin of rabbits. On the other hand, there is a description, "moderately irritating in the skin" as an effect on human health in HSDB (2004). classification is not possible due to insufficiency of data, because there is no other datum.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		For animals, it has been described that "In the test where 100 mg of this substance was medicated to the conjunctival sac of a rabbits' eye lids, mild corneal opacity, moderate to severe redness and edema of the conjunctiva were seen in 2/3 rabbits, and such symptoms disappeared in 72 hours."(DFGOT vol.3 (1992)). For humans, there are descriptions of "In some people, a minimal eye irritation with 3 to 5 ppm may occur." in the clause of the human health effect of HSDB (2004) and of "An eye is irritated and redness and pain are found in the eye as acute symptoms." in MOE Risk Assessment, Volume 4 (2005)). As mentioned above, it was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Classification is not possible since there is no data.
5 Germ cell mutagenicity Classification not possible - - - - Although there is a description of "slightly positive" by a body cell in vivo mutagenicity test (micronucleus tests which employed mouse erythrocyte) (DFGOT vol.3 (1992)), EU-RAR which is about isomer 1,2,4-trichlorobenzene (2003) described on this test that "a question lingers in the validity of positive finding since the test protocol is not so suitable"On the other hand, there is a description that the in vitro mutagenicity test (chromosome aberration test employing a chinese hamster cells and ames test employing salmonella typhimurium) was "negative" (CaPSAR (1993), NTP DB (Access on December 2008), and DFGOT vol.3 (1992)). As mentioned above, since there is not enough data for classifying, classification is not possible.
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - In the MOE Risk Assessment, vol. 4 (2005), it was reported that in a gavage oral administration study in 6-15 day pregnant rats, "a significant increase in liver weight and decreases in hemoglobin concentration and hematocrit value were observed in mother animals, but the number of fetuses, fetal weight and malformations in the skeleton and organs were not observed." HSDB (2004) also reported about the same study that "the abnormalities in the pregnancy results do not appear to be related to the exposure." Incidentally, in a gavage oral administration study in 6-15 day pregnant rats, it was reported that "liver and thyroid pathologies and decreases in hematocrit value and hemoglobin concentration were observed in mother animals. Slight osteogenic changes in fetuses were observed, but there were no severe malformations" (Patty (5th, 2001), DFGOT vol. 3 (1992)), and that "a teratogenic study showed no embryotoxicity and fetotoxicity" in DFGOT vol. 3 (1992). It is also reported in a 13-week feeding study in rats that "no effects on the weight of reproductive organs or on the tissues were observed in males and females" (MOE Risk Assessment, vol. 4 (2005)). However, since there is no data concerning effects on the reproductive functions and the data is insufficient classification is not possible.
8 Specific target organ toxicity - Single exposure Category 2 (digestive system), Category 3 (respiratory tract irritation) Warning H371: May cause damage to organs (digestive system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		As for humans, The paragraph of the clinical effect of HSDB (2004) has descriptions that "headache, nasal drainage, cough, breathlessness, chest pain, bronchus spasm, and rarely upper airway swelling and acute lung injury may occur as results of inhalation exposure", that "cough after inhalation, tachypnea, and wheezes are common" and that "there is a possibility of nausea, vomiting, and diarrhea when oral ingestion is carried out." Moreover, the paragraph of human influence of the 4th volume (2005) of MOE Risk Assessment has a description that "an airway is stimulated, cough and pain in the throat were seen as acute symptoms, and stomachache, diarrhea, nausea, and vomiting were developed by oral ingestion." As mentioned above, it was classified into Category 2 (digestive system) and Category 3 (Respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, thyroid) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, thyroid) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It has been described that, in the 13-weeks mixed feed administration test employing rats, " the weight increase of liver and kidney in female, increase of hepatic cell capacity and anisokaryosis increase in male and female, follicle reduction in thyroid gland, increase of the height of a follicular cell, colloid density reduction."(MOE Risk Assessment, Volume 4 (2005)), CaPSAR (1993), Patty (5th, 2001), DFGOT vol.3 (1992)). Since these symptoms were seen within the range of the guidance value of Category 2, it was classified into Category 2 (liver, thyroid). In addition, for humans, although there are descriptions of "The woman who had immersed the work clothes in Chlorobenzenes and washed them for a long period of time had experienced the aplastic anemias."(MOE Risk Assessment, Volume 4 (2005)), Patty (5th, 2001) and of "Some worker of 28 workers who was exposed to Trichlorobenzenes complained headache, giddiness, deep sleep, and indigestion" (MOE Risk Assessment, Volume 4 (2005))), the isomer has not been identified and it is unknown whether it is the influence due to this substance, it is not adopted.
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

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Model SDS by MHLW

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