GHS Classification Result

Chemical Name：Dodecan-1-ol
CAS：112-53-8

Result：
ID: 1-273
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition temperature 275degC (Lide,88th,2007)).
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Although the oral administration test employing a rat showed that LD50 value >12.8 mL/kg of (10,600 mg/kg), >36 mL/kg (29,880 mg/kg) (above, SIDS (1992)), >10,600 mg/kg, and >12,800 mg/kg (above, Patty (5th, 2001)), since all of them exceeded the baseline of Category 4, they were classified into "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Since LD50 value of the dermal administration test employing guinea pig was 10 mL/kg (8,309 mg/kg) (SIDS (1992)), it was classified into "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - It is written that in 1-hour, 6-hour, or 18-hour inhalation exposure test employing rats, there was no mortality with 1.05 mg/L in any exposure time (SIDS (1992)). Since it is a liquid whose saturated vapor pressure level at 25degC is 0.0086 mg/L, 4-hour LC50 value equivalent is considered to be >0.2625 mg/L when applying the mist standard. Since classification cannot be specified, classification is not possible.
2 Skin corrosion/irritation Not classified - - - - It was classified into "Not classified" because of "not irritating" (IUCLID (2000)) in a 4-hour skin irritation/corrosion test to human (OECD TG 404, GLP). In addition, although there has been a description of "highly irritating" (IUCLID (2000)) in the Draize test with rabbits, it has been described in the primary literature (J. Soc. Cosmet. Chem. 28 (1977)) that the test was a 24-hour test and "the degree of irritation declines in order of rabbits, guinea pig, mise, and humans." Moreover, there has been a description of "slight to moderate irritation" (Patty (5th, 2001)) in the 24-hour skin irritation tests employing rabbits and mice. Since either of them are a 24-hour test, they cannot be employed.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		This substance was set to Category 2B since it showed a "mild irritation (mainly to conjunctiva)" in the eye irritation test employing rabbits for the commercial Laurylalcohol A and B in 68.9% and 63.3% of each of which this substance was contained (SIDS (1992)), and every rabbit recovered in 14 days. In addition, each ingredient of the commercial Laurylalcohol A and B is a higher alcohol, being indicated below. A: C10 accounts for 0.3%, C12 for 68.9%, C14 for 25.1%, C16 for 5.1%, and C18 for 0.3%. Remaining 0.3% is unidentified. B: C10 accounts for 0.1%, C12 for 63.3%, C14 for 24.1%, C16 for 8.3%, and C18 for 0.4%. Remaining 3.8% is unidentified.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Although there is a data of "not sensitizing" (IUCLID (2000)) in the Maximization tests to humans (volunteers of 25 persons), classification is not possible since the source of information is from List2 and data is insufficient.
5 Germ cell mutagenicity Not classified - - - - Since it was negative in the body cell in vivo mutagenicity test (micronucleus tests which employed the mouse bone marrow cell) (SIDS (1992)), it was classified into "Not classified".
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible. In addition, there is a description that "the statistical increase in a lung neoplasm was not seen in the intraperitoneal injection experiment employing mouse. Although mild cancer adjuvant effect was seen by repeated topical use, there is a question in a conclusion because the difference between a processing group and a non-processing group is small" (SIDS (1992)).
7 Reproductive toxicity Classification not possible - - - - In a combined repeated dose toxicity study and reproductive/developmental toxicity screening study in rats (OECD TG 422, GLP), it was reported that "for parental toxicity, although there was a slight decrease in conception rates it was not statistically significant, there was no change in the gestation period, and abnormalities of the reproductive organs were not observed. For developmental toxicity, there were no changes in natality rates, offspring weight, mortality rates or sex distribution, and no abnormalities were observed during autopsies" (SIDS (1992)). Since this study was a simple test, however, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 2 (lung) Warning H371: May cause damage to organs (lung) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There is a description of "Sign of lung irritation, mild breathing difficulty, mild hemorrhage in the lungs" occur in the inhalation exposure test employing rats (SIDS (1992)), and since all cases were seen within the range of the guidance value of Category 2, it was classified into Category 2 (lungs).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - It is written in the combination test of repeated dose toxicity study and reproduction screening study in rats (OECD TG 422, GLP) that there were no pathological effects, however, there were decrease in number of white blood cells and decrease in plasma free cholesterol" (SIDS (1992)) . Since effects on the blood are found out of the scope of Category 2, classification is not possible.
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours EC50=0.97mg/L of the algae (Scenedesmus) (SIDS (1998)).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity was Category 1, since there were bio-accumulation (LogKow=5.13 (PHYSPROP Database (2008))), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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