GHS Classification Result

Chemical Name：2,3,5,6-Tetrachloro-p-benzoquinone
CAS：118-75-2

Result：
ID: 1-264
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Not classified - - - - Non-combustible (ICSC,1997).
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition temperature >400 degC (Merck KGaA data from March 2009)).
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC,1997).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - Although it is an organic compound including oxygen and chlorine, not fluorine, these oxygen and chlorine have not chemically bound to any elements other than carbon and hydrogen.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - From LD50 value 6,951 mg/kg (HSDB (2002)), 4,000-7,100 mg/kg (BUA 85 (1993)), and 4,000 mg/kg (RTECS (2008)) of the oral administration test employing rats, the lower value of 4,000 mg was adopted. Although this LD50 value corresponded to the U.N. GHS acute toxicity Category 5, it fell under unadopted category in Japan and was classified into "Not classified".
1 Acute toxicity （Dermal） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		This substance is a solid whose saturated vapor pressure level is 0.000067 mg/L (25degC). It is written that LC50 value of the 4-hour inhalation exposure test employing rats is 2,485 mg/L (RTECS (2008)). The dust standard was applied and it was classified into Category 4.
2 Skin corrosion/irritation Classification not possible - - - - Although there are descriptions, saying, "There is possibility to stimulate the skin,"(HSDB (2002)) and " Irritation response to the skin is weak,"(BUA 85 (1993)), classification is not possible because data are insufficient. EU division is Xi; R36/38 (EU-Annex I).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Since there were descriptions of "mucosa may be irritated in the section of human influence" (HSDB (2002)), "The corneal necrosis was caused" (HSDB (2002)) in the test where dry powder was applied to the eye of the rabbit, and "Severe irritation and irreversible injury are caused."(BUA 85 (1993)), it was classified into Category 1. EU classification is Xi; R36/38 (EU-Annex I).
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Classification is not possible since there is no data.
5 Germ cell mutagenicity Not classified - - - - It was classified into "Not classified" based on a statement that the in vivo mutagenicity test using a somatic (micronucleus tests which employs mouse erythrocyte) was "negative" (BUA 85 (1993)). In addition, there is a description that "there was also a kind which indicated to be a positive" by mutagenicity test murine Salmonella typhimurium (NTP DB (Access on September 2008)).
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no sufficient data, classification is not possible. In addition, there is a description that "insecure carcinogenicity" in the oral administration test employing mice (HSDB (2002)), and another description that "although the tumor was seen at male liver and male lung, there were small examples of generating" in oral study for 18 months employing mice (BUA 85 (1993)).
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects, Respiratory tract irritation） Warning H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation)
H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		For laboratory animals, there are descriptions of "potential of causing diarrhea or central nervous system depression" (HSDB (2002)) and of "water diarrhea, a spasm, and central nervous system depression" (BUA 85 (1993)) in the oral administration test employing rats. Moreover, there are descriptions of "the structural or functional change of somnolence, tracheal gill, and bronchus " (RTECS (2008)) and description "It irritates a respiratory tract."(ICSC (1997)), in the inhalation exposure test employing rats where lethal dose is found. As mentioned above, it was classified into Category 3 (Narcotic effects, Respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Category 2 (central nervous system, digestive system) Warning H373: May cause damage to organs through prolonged or repeated exposure (central nervous system, digestive system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		About humans, HSDB (2002) which is the source of information of List2 has description of "diarrhea, central nervous system control, and coma," For laboratory animals, in 28 days forcible oral administration test employing rats (OECD TG 407, GLP) there is a description of "increased serum total Bilirubin in male," "loose stools in male, diarrhea, proventriculus in male and female, and fault formation of a membrane epithelium in the intestines including mainly cecum, change of erosions " (CHRIP (Access on October 2008)) and although the effect on the digestive system is the symptom seen in 800 mg/kg (the equivalent on the 90 days corresponding value: 249 mg/kg), the diarrhea was observed also in humans, thus, it was classified into Category 2 (central nervous system, digestive system).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96 hours LC50=4.6mg/L of the fish (Carp) (BUA 85 (1992)).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 2 and there were no data about rapid degradability, it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information