GHS Classification Result

Chemical Name：Sodium 1-(methoxycarbonyl)pentadecane-1-sulfonate
CAS：4016-24-4

Result：
ID: 1-241
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Classification not possible - - - - Classification not possible due to lack of data
11 Self-heating substances and mixtures Classification not possible - - - - Classification not possible due to lack of data
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - It is stable in water (water solubility 271.9 mg/L, SIDS-SIAR(2003))
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Classification not possible - - - - Although it is an organic compound including oxygen having chemically bound to elements other than carbon and hydrogen, classification is not possible due to lack of data.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		From the description of LD50 value of 1,819 mg/kg of the oral administration test employing a rat (female) (OECD TG401, GLP), 2,142 mg/kg (male) (Health, Labor and Welfare Ministry reports (Access on November 2008)), LD50 value of 700-1,400 mg/kg of the oral administration test employing a rat (male) (SIDS (2003)), OECD TG and GLP based test data of 1,819 mg/kg was adopted, and it was classified into Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - There is a description of "slight irritating" (SIDS (2003)) in the Draize test employing guinea pig. However, since there is no data except that the diluted solution with mixture of this substance and Tetradecanoic acid-2-sulfo-1-methyl ester sodium salt (16%) was used in this test, classification is not possible.
3 Serious eye damage/eye irritation Classification not possible - - - - Classification not possible due to lack of data
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - It has been described that "it was SI <3 and had no sensitizing potential up to 25% of the highest test concentration" (SIDS (2003)) in the LLNA test (OECD TG 429) employing mice. Classification is not possible because of unknown details and no other data.
5 Germ cell mutagenicity Classification not possible - - - - Classification is not possible because there is no data of in vivo examination. In addition, there is a description that the in vitro mutagenicity test (chromosome aberration test employing a CHL/IU cell) is "negative" (Health, Labor and Welfare Ministry reports (Access on November 2008)).
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - In a combined repeated dose toxicity study and reproductive/developmental toxicity screening study in rats (OECD TG 422, GLP), it was reported that at doses at which changes in the anterior stomach are observed in mother animals, "no changes attributable to the administration of the substance were observed in reproductive capacity or organs, and for the offspring, no changes attributable to the administration of the substance were observed in the numbers of total births and neonates, sex distribution, birthrate, weight, morphology and 4-day survival rate from the start of rearing" (Ministry of Health, Labor and Welfare Report (Access on November 2008)), but classification is not possible due to insufficient data.
8 Specific target organ toxicity - Single exposure Category 2 (systemic toxicity) Warning H371: May cause damage to organs (systemic toxicity) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the oral administration test employing rats (OECD TG 401, GLP), "After administration, locomotor activity reduction, droopy eyelid, diarrhea, and the lower abdomen hair contamination and piloerection by them were observed. There is a description of "The symptoms were observed to tend to recover 1st day after administration and all of them recovered by 6th day."(Health, Labor and Welfare Ministry reports (Access on November 2008)). Since these effects were seen within the range of the guidance value of Category 2, it was classified into Category 2 (systemic toxicity).
9 Specific target organ toxicity - Repeated exposure Category 2 (digestive system) Warning H373: May cause damage to organs through prolonged or repeated exposure (digestive system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It is written in the combination test of repeated dose toxicity study and reproduction screening study by forced oral administration test in rats (OECD TG 422, GLP) that "there were hyperplasia of stratified squamous epithelium accompanied with anterior stomach hyperkeratosis, lamina propria mucosae and mild - severe edema of submucosa" and "there were increase in serum GPT and decrease in triglyceride in males" (Ministry of Health, Labour and Welfare reports (Access on November 2008)). However, it is written in Ministry of Health, Labour and Welfare reports (Access on November 2008) that "anterior stomach changes are considered to be inflammation due to localized injury and reactive hyperplasia of epitheliuma," "although increase in GPT is judged to be a change resulting from administration of test article, there were no histopathologic change in liver, and no other relevant changes" and "changes in triglyceride are very mild within the normal range in the background data, it is thought that toxicological significances are small", and it is summarized that "main toxicity is an effect on anterior stomach ". These effects were found within the scope of the guidance value of Category 2. For the reasons stated above, we classified it as Category 2 (digestive system).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48 hours EC50=1.2mg/L of the crustacea (Daphnia magna) (Environmental Agency eco-toxicity tests of chemicals (2000)).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 2, there were rapid degradability (easily biodegradable, the decomposition by BOD: 91-94% (SIDS (2005))) and there were bio-accumulation (LogKow = 4.06 (SIDS (2005))), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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