GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Hydrogenated terphenyl
CAS：61788-32-7
Result：
| ID: | 1-238 |
| Classifier: | Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE） |
| Year Classified: | FY2008 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （Sep, 2008） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid |
| 6 | Flammable liquids | Not classified | - | - | - | - | Since the flash point by ICSC(1995) is 157degC(closed type), it was classified into Not classified. |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 374degC (ICSC,1995)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | The test method suitable for liquid substances is not established. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included. |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | It is an organic compound not containing oxygen, fluorine or chlorine. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid |
| 15 | Organic peroxides | Not applicable | - | - | - | - | The organic compound not including peroxy group in molecule. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | Although LD50 value of the oral administration test employing a rat includes 6,600 mg/kg (Patty (5th, 2001)), 17,500 mg/kg, and 10,200 mg/kg (ACGIH (7th, 2001)), it classified into "Not classified" from 6,600 mg/kg which is a low value and is new data. |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | From LD50 value >2,000 mg/kg (IUCLID (2000)) of the dermal administration test (OECD TG 402, GLP) employing a rabbit, it was classified into "Not classified". |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable". |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | This substance is a liquid whose saturated vapor pressure level at 25degC is 1.3 mg/L (128 ppm). Since LC50 value of 4-hour inhalation exposure test employing rats is >4.7 mg/L (ACGIH (7th, 2001)), and LC50 value of 4-hour aerosol inhalation exposure test employing rats (OECD TG 403, GLP) is >4.3 mg/L (IUCLID (2000)), and any of them are over saturated vapor pressure level, the mist standard was applied, however, classification cannot be specified, classification is not possible. |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
Although there are descriptions, "moderately irritating, PII value=3.01" and "not irritating, PII value = 0.04" (IUCLID (2000)) in the information source of List 2 in the 24 hour Draize test using 2 rabbits, irritation caused with this substance cannot be denied, because there is a description, "There is a moderate irritation in the rabbits' skin" in the information source of List 1. Therefore, it was classified in Category 2. |
| 3 | Serious eye damage/eye irritation | Not classified | - | - | - | - | From the description of "nonirritating" (ACGIH (7th, 2001)) and of "Draize score:0.3/110" in the eye irritation/corrosion test employing rabbits (OECD TG 405, GLP) (IUCLID (2000)) to eyes of rabbits, it was classified into "Not classified ". |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | Classification is not possible since there is no data. |
| 4 | Skin sensitization | Not classified | - | - | - | - | It was classified into "Not classified" since there is a description of "no sensitization" in the two human patch tests including 50 persons and 51 persons (one case in ACGIH (7th, 2001) and two cases in IUCLID (2000)). |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | It was classified into "Not classified" based on the statement that the body cell in vivo mutagenicity test (chromosome aberration test employing rats bone marrow cell (OECD TG 475, GLP)) was "negative" (ACGIH (7th, 2001), IUCLID (2000)). In addition, as for in vitro mutagenicity tests, there are also descriptions that the Ames examination employing the Salmonella typhimurium, the HGPRT examination employing a CHO cultivation cell, and UDS test employing a rat liver cultivation cell are all "negative" (ACGIH (7th, 2001), IUCLID (2000)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | Since no evaluation by major international evaluation agencies is made and there is no sufficient data, classification is not possible. In addition, there is a description of "not carcinogenicity" (ACGIH (7th, 2001)) and an "uninfluential at dose 50 mg/L" (IUCLID (2000)) in the 37-week dermal administration test employing male and female mice. |
| 7 | Reproductive toxicity | Not classified | - | - | - | - | There is a report of "no teratogenicity at doses at which no adverse effects are observed in mother animals" (ACGIH (7th, 2001), IUCLID (2000)) in a prenatal developmental toxicity study in rats (OECD TG 414, GLP). It is also reported in a teratogenicity study in rats (Bio dynamics, Inc, method, GLP) that "there are no effects on the offspring at doses at which decreased feed intake was observed in mother animals" (IUCLID (2000)). In addition, it is reported that "there were no dose-dependent effects on mating or fertility of parent animals which were fed with 30, 100, 300, 1000 ppm (corresponding values: 1.8-2.5, 6.1-8.3, 18.5-24.4, 62.0-81.2 mg/kg) of the substance, and no histopathological degenerations in reproductive organs which were related to administration of the substance" (USCh (2004)) in a two-generation reproductive toxicity study in rats (OECD TG 416, GLP). For the reasons stated above, it was classified into "Not classified". |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Respiratory tract irritation） |
|
Warning | H335: May cause respiratory irritation (respiratory tract irritation) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
About humans, there are descriptions that "irritation on an upper respiratory tract and nausea symptoms are present" when aerosol was inhaled (ACGIH (7th, 2001)), and that "an airway is stimulated" in the acute inhalation exposure test employing rats, (ACGIH (7th, 2001)) ", therefore, it classified into Category 3 (Respiratory tract irritation). In addition, the acute oral toxicity tests employing rats (OECD TG 401, GLP) has a description that "control of spontaneous movement, and dirt on hairs by diarrhea, feces and urine were seen with general findings, but necropsy findings were normal in all animals" by 10,000 mg/kg (USCh (2004)). Moreover, there is a description that "short term exposure effect: eyes, skin, and respiratory tract are stimulated" (ICSC (1995)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver) |
|
Warning | H373: May cause damage to organs through prolonged or repeated exposure (liver) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
In a 20-day dermal administration test with rabbits (International Research and Development Corp. method, GLP) it was reported that "at mg/kg there was no systemic toxicity" (ACGIH (7th, 2001), IUCLID (2000)), and in a 90-day oral administration study with rats (OECD TG 408, GLP) it was reported that "there were weight increase in the liver, kidney and adrenal gland (females only) and weight loss in female animals but no toxic effects related to administration of this substance in histopathological studies " (USCh (2004), IUCLID (2000)). Also, in a 90-day aerosol inhalation exposure test with rats (OECD TG 413, GLP) there is a report of "weight loss, increased liver weight and chromodacryorrhea" (IUCLID (2000)), and in a 182-day aerosol inhalation exposure test with rats (Industrial Biotest Laboratory, Inc. method) there is a report of "an increase in SGOT, SAP and SGPT, a reduction in BUN and an increase in liver weight" (IUCLID (2000)). Since these effects are within the range of guidance values for Category 2, we classified it as Category 2 (liver). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | The substance is hydrocarbon. Although the kinematic viscosity estimated from the viscosity of 70 mPa/s (20degC) (15107 Chemical Products) and the density of 1.011 g/cm3 (15degC) (IUCLID (2000)) is 69.2 mm2/s (20degC) and the viscosity at 40C is expected to be lower than 69.2 mm2/s, classification is not possible since it is unknown whether or not the figure is less than the reference value of 20.5 mm2/s. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |