GHS Classification Result

Chemical Name：Sodium bromate
CAS：7789-38-0

Result：
ID: 1-235-2）
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Although the atom group (O-halogen) concerning explosiveness is included, it was classified into Not classified since it was classified into Class 5.1and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1494(ICSC,2006)).
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Not classified - - - - Since it was classified into Class 5.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1494(ICSC,2006)), it was classified into Not classified.
8 Self-reactive substances and mixtures Not classified - - - - Although the atom group (O-Br) associated with explosive properties is included, it was classified into Not classified, since it was classified into Class 5.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1494(ICSC, 2006).
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC(2006)).
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC(2006)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Category 2 Danger H272: May intensity fire; oxidizer P370+P378: In case of fire: Use ... for extinction.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P221: Take any precaution to avoid mixing with combustibles/...
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since it was classified into Class 5.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1494(ICSC,2006)), it was classified into Category 2.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Dermal） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - Although there is a description saying, "Prolonged contacts of Bromate cause burns on the scarf skin of rabbits but they recover in a few days,"(Patty (5th, 2001)), classification is not possible because there is no information at the time of 4- hour exposure. Incidentally, there is a description, "It stimulates the skin, "in the section of the Effect of Short Term Exposure in ICSC (2006).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		From the description that "Although Bromate causes moderate irritation and slight corneal injury in eyes of of a rabbit, it will recover in several days " (Patty 5th, (2001)), it was classified into Category 2B. In addition, there is a description of "Eyes are stimulated." in the paragraph of short-term exposure effects of ICSC (2006).
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Classification is not possible since there is no data.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there is a description of all being "positive" (NTP DB (Access on December 2008)) in the body cell in vivo mutagenicity test (micronucleus tests employing the erythrocyte of the mouse of three cases), since there was no positive result of the productive cell in vivo genotoxicity test, it was classified into Category 2. In addition, there is a description of "negative" (NTP DB (Access on December 2008), HSDB (2003)) in the in vitro mutagenicity test (reverse mutation test employing a Salmonella typhimurium).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there is no evaluation of this substance as is, it was classified in Category 2, based on the description in ACGIH (7th, 2001), "EPA Classification: L (oral), B2." In addition, there is a description as follows (NTP DB (Access on December 2008)), "Tumors caused by the administration was not observed" in the study to administer drinking water to male and female mice for 27 and 43 weeks and the dermal administration test with male and female mice for 26 and 39 weeks. Moreover, as for the related compound potassium bromate, GHS Classification has been made Category 2, because IARC is Group B and EU Classification is Carc. Cat. 2; R45 (EU-Annex 1).
7 Reproductive toxicity Not classified - - - - There are descriptions as follows in NTP DB (Access on december 2008) "At the dose level where kidney cell proliferative changes in female rats and chronic nephropathy and accumulation of hyaline droplets in male rats can be observed, no effect relating to the sdministration was found in female rats' reproductive capability (NTP (2001), Unaudited Draft Final Report).in the multigeneration reproductive toxicity study via administration of drinking water using male and female rats. Reduction in sperm concentrations was found with male F0 parent animals and reduction in sperm concentrations was also found with male F1 child animals, although there is no statistical significance, "and " Although no toxicity relating to female rats' reproduction was observed, reduction in sperm concentrations of dose dependence nature was observed with male rats in the reproductive toxicity screening study via drinking water administratin using male and female rats. There was, however, no effect on their fertility property." For the reasons stated above, it was classified into "Not classified".
8 Specific target organ toxicity - Single exposure Category 1 (kidney, nervous system, digestive system, blood system), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (kidney, nervous system, digestive system, blood system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		As for toxic symptoms of Bromate Anemia, there is a description that "hemolysis, kidney trouble, and hardness of hearing" were seen in humans who did oral ingestion of the solution containing this article (EHC 216 (2000), IRIS (2001)), and another description that "Vomiting, a stomachache, and diarrhea were seen as irritant effect on the gastrointestinal effect and a lethargy low blood pressures, hypotonia (hypotonicity), and reflexes absents were seen as central nervous system effect" (IRIS (2001)). Moreover, the paragraph of a GHS classification of ICSC (2006) has a statement that "kidney and a nervous system are impaired when oral ingestion is carried out," and the paragraph of short-term exposure influence has a description that "Airway will be stimulated. Kidney and nervous systems may be affected and kidney failures, respiratory dysfunction, deafness and peripheral neuropathy may be produced when oral ingestion is carried out." As mentioned above, it was classified into Category 1 (kidney, nervous systems, digestive system, blood systems) and Category 3 (Respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Category 2 (thyroid, kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (thyroid, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In the dermal administration test for 26 weeks and 39 weeks using male and female mice, "follicular cell hypertrophy was observed in thyroid" (NTP DB (Access on December 2008)). Moreover, in the 27-week and 43-week study of administration in drinking water to male and female mice, "on thyroid findings, follicular cell hypertrophy, depleted follicular secretion and an increase in lymphocytic infiltrate were seen, and about the kidney results, kidney syndrome and kidney tubule hypertrophy were observed" (NTP DB (Access on December 2008)). Since these effects were observed within the limits of the guidance value of Category 2, it was classified into Category 2 (thyroid, kidney). In the multi-generation reproduction toxicity study of administration in drinking water to male and female rats (NTP (2001), Unaudited Draft Final Report), "proliferation of kidney cells was observed in female rats, and chronic nephropathy and hyaline droplet accumulation were observed in male rats" (NTP DB (Access on December 2008)), but hyaline droplet is considered to be a symptom peculiar to male rats because there is the description that it is "a symptom caused by excessive accumulation of alpha2u globulin to kidney tubule" (IARC 73 (1999), NTP DB (Access on December 2008)). Moreover, in the reproductive toxicity screening study using male and female rats, "although a dose-dependent decrease in sperm concentration was observed in male rats, any effects associated with the dose were not observed in the histopathological examination of liver, kidney, lien, testis and epididymis" (NTP DB (Access on December 2008)).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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