GHS Classification Result

Chemical Name：Potassium bromate
CAS：7758-01-2

Result：
ID: 1-235-1）
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Although the atom group (O-halogen) concerning explosiveness is included, it was classified into Not classified because it was classified into Class 5.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods(UN No.1484 (ICSC,2003)).
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Not classified - - - - Since it was classified into Class 5.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1484(ICSC,2003)), it was classified into Not classified.
8 Self-reactive substances and mixtures Not classified - - - - Although the atom group (O-Br) associated with explosive properties is included, it was classified into Not classified, since it was classified into Class 5.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1484(ICSC2003).
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC(2003)).
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC(2003)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Category 2 Danger H272: May intensity fire; oxidizer P370+P378: In case of fire: Use ... for extinction.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P221: Take any precaution to avoid mixing with combustibles/...
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since it was classified into Class 5.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1484(ICSC,2003)), it was classified into Category 2.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		There is a description of LD50 value 400-500 (495) mg/kg (IARC 73 (1999), JECFA (1992)), and 160-190 mg/kg (JECFA (1992)) of the oral administration test employing a rat. These values were classified into Category 4 from the description that "They are male:400 (348-460) mg/kg and female:495 (446-549) mg/kg as a result of carrying out statistics processing of the LD50 value." in information from same reference (Environ.Health Perspect.87 (1990)).
1 Acute toxicity （Dermal） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - Although there is a description saying, "Prolonged contacts of Bromate cause burns on the scarf skin of rabbits but they recover in a few days,"(Patty (5th, 2001)), classification is not possible because there is no information at the time of 4- hour exposure. Incidentally, there is a description, "It stimulates the skin, "in the section of the Effect of Short Term Exposure in ICSC (2006).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		From the description that "Although Bromate causes moderate irritation and slight corneal injury in eyes of of a rabbit, it will recover in several days " (Patty 5th, (2001)), it was classified into Category 2B. In addition, there is a description of "Eyes are stimulated." in the paragraph of short-term exposure effects of ICSC (2003).
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Classification is not possible since there is no data.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although there is a description of "positive" (IARC 73 (1999), JECFA (1992), IRIS (2001)) in the body cell in vivo mutagenicity test (micronucleus test employing the bone marrow cell and erythrocyte of the mouse, the chromosome aberration test using the marrow cells of the rat), since there was no positive finding of the productive cell in vivo genotoxicity test, it was classified into Category 2. In addition, for the body cell in vivo genotoxicity test IARC 73 (1999), there are descriptions of "positive" in the DNA damage test employing the kidney of the rat, "Slightly positive to negative" (IARC 73 (1999)) in the DNA damage test employing the liver of the rat, and "positive" in either of the in vitro mutagenicity test (chromosome aberration test employing CHL culture cells and the reverse mutation test employing a Salmonella typhimurium).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		IARC evaluates it as group 2B (IARC 73 (2000)), and the European Union classification evaluates it as Carc. Cat. 2; R45 (EU-Annex I). According to guidance, priority was given to the classification of IARC and it classified into Category 2. In addition, ACGIH (7th, 2001) has a description of "EPA classification of Bromate: L (oral), B-2."
7 Reproductive toxicity Classification not possible - - - - Classification is not possible because there is no data. Incidentally, GHS Classification of the related compound, Sodium bromate is "Not classified" based on results of the multi-generation reproductive toxicity study via administration of drinking water using male and female rats.
8 Specific target organ toxicity - Single exposure Category 1 (kidney, central nervous system, digestive system, blood system), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (kidney, central nervous system, digestive system, blood system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		As for toxic symptoms of Bromate Anemia, there is a description that "hemolysis, kidney trouble, and hardness of hearing" were seen in humans who did oral ingestion of the solution containing this article (EHC 216 (2000), IRIS (2001), JECFA (1992)), and another description that "Vomiting, abdominal pain, and diarrhea were seen as irritant effect on the gastrointestinal effect, and a lethargy dizziness, low blood pressures a hypotonia (hypotonicity), and reflexes absents were seen as central nervous system effect" (IRIS (2001), JECFA (1992)). Moreover, the paragraph of short-term exposure effects of ICSC (2003) has a description that "a respiratory tract is stimulated. The kidney and a central nervous system may be affected and kidney insufficiency, respiratory depression, and hardness of hearing may be produced when oral ingestion is carried out." As mentioned above, it was classified into Category 1 (kidney, central nervous systems, digestive system, blood systems) and Category 3 (Respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In the 13-week study of administration in drinking water to male and female rats, "on blood biochemical findings, an increase in GOT, GPT, LDH, ALP, BUN, serum sodium and cholinesterase were observed in male and female rats, and droplet in proximal tubule epithelial cytoplasm and a broad range of reproductive changes in kidney tubule were observed in male rats" (IRIS (2001), JECFA (1992)). Moreover, in the 100-week study of administration in drinking water to male rats and male mice (IRIS (2001)), on findings in rats "a statistically significant reduction of drinking water intake was observed in the high-dose group, but any other effects associated with the dose were not observed," and "a dose-dependent increase in the incidence rate of urothelium hyperplasia, mineral deposits in kidney papillary and eosinophilic droplet in proximal tubular epithelium were observed." In the 12-week study of administration in drinking water to male rats, "the droplets observed in kidney tubule are concluded to be more of eosinophilic bodies than hyaline droplets" (EHC 216 (2000), JECFA (1992)). The kidney symptoms were observed only in male rats and considered as the effects by alpha2u globulin nephropathy. Since there is no other data available, classification is not possible. In addition, for a related compound, sodium bromate, kidney is selected as the target organ since "kidney syndrome and kidney tubule hypertrophy were observed in kidney" (NTP DB (Access on December 2008)) in the 27-week and 43-week study of administration in drinking water to male and female mice.
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

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Model SDS by MHLW

 MHLW Website （in Japanese Only）

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