GHS Classification Result

Chemical Name：2,4-Dimethylaniline
CAS：95-68-1

Result：
ID: 1-214
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since the flash point by ICSC(2007) is 90degC, it was classified into Category 4.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Since it was classified into Class 6.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1711 (ICSC, 2007)), it was classified into Not classified.
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - It is an organic compound not containing oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		From a description of LD50 value of 470 mg/kg (DFGOT vol.19 (1998), ACGIH (7th, 2001)) in the oral administration test employing rats, it was classified into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - There is description of LD50 value 3,300 mg/kg of the dermal administration test employing a rabbit (DFGOT vol.19 (1998)). Although LD50 value seemed to be equivalent to the U.N. GHS acute toxicity (dermal) Category 5, it fell under unadopted category in Japan and was classified into "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Saturated vapor pressure level of this substance (25degC)is 175 ppm (0.867 mg/L). Since LC50 value with 1.53 mg/L of the 4-hour inhalation exposure test employing rats (DFGOT vol.19 (1998)) was larger than saturated vapor pressure level, it was classified into Category 4 by applying the mist standard.
2 Skin corrosion/irritation Not classified - - - - It is described as "not irritating" (DFGOT Vol. 19 (1998)).for the skin irritation test comforming to OECD TG. Moreover, it is described as "skin: weak irritation" in BUA 161 (Summary, 1994). Although it seemed to correspond to UN GHS Skin irritation Category 3 based on the above-mentioned, it was classified into "Not classified", because Category 3 is not domestically adopted. In addition, there is a description, "It stimulates the skin.........causes reddening, when contacting the skin" in the section of Effects on Humans of the MOE Risk Assessment Vol 6 (2008). Moreover, there is a description "mildly irritating" in the section of EFFECTS OF SHORT-TERM EXPOSURE in the cited literature ICSC (2007).
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		In the eye irritation examination in conformity to OECD TG, it has been described as "irritating" (DFGOT vol.19 (1998)). Moreover, it is described as "eye: irritant" in BUA 161 (Summary, 1994). As mentioned above, since the degree was unknown, it was not classified finely and was classified into "Category 2". In addition, the clause of influence in MOE Risk Assessment, Volume 6 (2008) describes as "It irritates the eye, and ... when it goes into the eye, redness and pain are caused." Moreover, it is described as "irritating" in the clause of EFFECTS OF SHORT-TERM EXPOSURE of ICSC (2007) which is a cited literature.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Classification is not possible since there is no data.
5 Germ cell mutagenicity Classification not possible - - - - Although there is a description of "positive" in the in vitro mutagenicity test (Ames test employing a Salmonella typhimurium) (NTP DB (Access on October 2008)), classification is not possible because there is no data of in vivo examination.
6 Carcinogenicity Not classified - - - - Since IARC has a description of group 3 (IARC Suppl.7 (1987)), it was classified into "Not classified" according to guidance. However, it is classified into the Category 2 (DFGOT vol.19 (1998)) in Germany DFG.
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 1 (blood system) Danger H370: Causes damage to organs (blood system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		For animals, there is a description of "Hyperpnea was seen." in 4 hours inhalation exposure test employing rats (DFGOT vol.19 (1998)), and there is a description of "Methemoglobin was produced about 1 hour and a half after administration" in the oral administration test where the lethal dose in rats were calculated (DFGOT vol.19 (1998)). All these symptoms were seen within the range of the guidance value of Category 1. Although there is no data of this substance on the humans, the report that "2,6-xylidine, which is an isomer, caused methemoglobinemia on humans." is described in DFGOT vol.19 (1998). As mentioned above, it was classified into Category 1 (blood systems). In addition, in ICSC (2007), "The high concentration exposure may cause lowering of consciousness. The high concentration exposure may produce methemoglobin. These effects may occur backwardly. Although there is a description of "Medical follow up is needed, the details of doses are unknown.
9 Specific target organ toxicity - Repeated exposure Category 1 (blood system, liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (blood system, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Within the limits of the guidance value of Category 1, "an increase in relative and absolute liver weight, an increase in hyaline droplet on the epithelium of kidney tubules of kidney, a decrease in the amount of hemoglobin, an increase in the platelet count and an increase in activated partial thromboplastin time were observed in male rats, and an increase in the amount of total cholesterol was observed in female rats, as well as hypertrophy of hepatocytes at the center of the hepatic lobule was observed both in male and female rats."(MOE Risk Assessment vol. 6 (2008)) Within the limits of the guidance value of Category 2, "an increase in relative and absolute liver weight, an increase in relative kidney weight, a decrease in the amount of hemoglobin and a decrease in the prothrombin time were observed in female rats" (MOE Risk Assessment vol. 6 (2008)). About the effects on the liver, from description in ACGIH (7th, 2001) that "hepatocellular necrosis and bile duct hyperplasia were observed in male rats" within the limits of the guidance value of Category 2, they are adopted to categorize. Since an increase in hyaline droplet on the epithelium of kidney tubules of kidney was only observed in male rats, it is not adopted to categorize. Therefore, it is classified into Category 1 (blood systems, liver).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48 hours EC50=9.9mg/L of the crustacea (Daphnia magna) (AQUIRE (2008)).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 2 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 0% (Existing Chemical Safety Inspections Data (1978)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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