GHS Classification Result

Chemical Name：2,2-Dibromo-2-cyanoacetamide
CAS：10222-01-2

Result：
ID: 1-210
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Not classified - - - - Non-combustible (HSDB,2002).
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Non-combustible (HSDB,2002).
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (HSDB,2002).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From a description of LD50 value of 235 mg/kg (male) and 178 mg/kg (female), (HSDB (2002)) in the oral administration test employing rats, it was classified into Category 3.
1 Acute toxicity （Dermal） Not classified - - - - Since LD50 value of the dermal administration test employing rabbits was >2 g/kg (2,000 mg/kg) (HSDB (2002)), it was classified into "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Saturated vapor pressure level of this substance (25degC)is 1.18 ppm (0.01 mg/L). Since LC50 value with 0.32 mg/L of the 4-hour inhalation exposure test employing rats (HSDB (2008)) was larger than saturated vapor pressure level, it was classified into Category 2 by applying the dust standard.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		There are descriptions, "Administration of 0.5g caused erythema followed by exfoliation and edema" (HSDB (2008)) in the 4 hour skin irritation test with rabbits and "moderate to severe" in the cited literature (USEPA, Reregistration Eligibility Desision Document). Moreover, there is a description , "Severe" (RTECS (2008)) in the standard Draize test with rabbits. It was classified in Category 2.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		It has been described that "there is severe damage to a corneal, no recoverability, and it is corrosive" (HSDB (2002)) in the eye irritation test employing rabbits. Moreover, it has been described as "Severe" (RTECS (2008)) in the standard Draize test employing rabbits. As mentioned above, it was classified into Category 1.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Although it has been described that "this substance is weak sensitizer" in the skin sensitization test employing guinea pig (HSDB (2002)), classification is not possible because of unknown number of animals being positive.
5 Germ cell mutagenicity Classification not possible - - - - Classification not possible due to lack of data
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - There is a description as follows in the developmental toxicity study via oral administration using rabbits of 7-19 day pregnancy, " Delayed ossification was observed in the skeletal element of a few fetuses at the dose level where general toxicity is not expressed" (HSDB (2008). Effect is nothing but "delayed ossification." Classification is not possible, because information is from the information source, List 2 and data related with female and male reproductive functions are not available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Classification not possible due to lack of data
9 Specific target organ toxicity - Repeated exposure Category 2 (systemic toxicity) Warning H373: May cause damage to organs through prolonged or repeated exposure (systemic toxicity) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It is written in 90-day oral administration test in rats that "there were some dyspnea, weight loss was found in those animals, and some were died" (HSDB (2002)) within the scope of the guidance value of Category 2. Since the organ could not be specified, it was classified into Category 2 (systemic toxicity). In addition, it is written in 90-day dermal administration test in rats that "there was decrease in triglyceride level in males, and rise in alkaline phosphatase and chlorine ion as well as decrease in cholesterol in females" outside the scope of the guidance value of Category 2 (HSDB (2002)).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=0.72mg/L of the crustacea (Mysid) (AQUIRE (2008)).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 1 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data (2008))), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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