GHS Classification Result

Chemical Name:Dibromochloromethane
CAS:124-48-1

Result:
ID: 1-209
Classifier: Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Not classified - - - - Non-combustible (ATSDR, 2005).
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Non-combustible (ATSDR, 2005).
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ATSDR, 2005).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Although it is an organic compound including chlorine, not fluorine and oxygen, this chlorine has not chemically bound to any elements other than carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
From a description of 370 mg/kg of lower value among LD50 value 370 mg/kg (MOE Risk Assessment, Volume 6 (2008)) and 848 mg/kg (ATSDR (2003)) in the oral administration test employing rats, it was classified into Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - Classification not possible due to lack of data
3 Serious eye damage/eye irritation Classification not possible - - - - Classification not possible due to lack of data
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Classification is not possible since there is no data.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since there is a description that a body cell in vivo mutagenicity test (chromosome aberration test employing rats bone marrow and the mouse bone marrow cell) was positive (ATSDR (2003) and NTP DB (Access on September 2008), and there was no positive finding of a productive cell in vivo genotoxicity testgenotoxicity test, it was classified into Category 2. In addition, there are descriptions that the micronucleus tests which employed mouse bone marrow cell was negative (ATSDR (2003)) and NTP DB (Access on September 2008)), and the DNA damage test using rats kidney and liver was negative (ATSDR (2003)).
6 Carcinogenicity Not classified - - - - Since IARC classification is a group 3 (IARC 71 (1999)) and the carcinogenicity classification of EPA (1986) is C (IRIS (1992)), it was classified into "Not classified". In addition, IARC 71 (1999) has a description that a result of the two-year oral administration examination of male and female mice and rats shows the significant increase in a liver cell neoplasm only with the female mice. There is no human data.
7 Reproductive toxicity Not classified - - - - Effects on testis, seminal capsule, uterus and other genital organs are not observed in the 13 week (5 days/week) forced oral administration study (dose 250mg/kg) and 104 week (5 days/week) forced oral administration study (dose 80mg/kg) (ATSDR (2003), NTP TR282 (1985)). Although suppression of increase in the body weight with 200mg/kg was observed in the oral administration reproductive toxicity study using rats of 6-15 day pregnancy, there was no effect on the number of resorption, child animals and fetuses, body weight and deformation of fetal animals (MOE Risk Assessment Vol. 6 (2008), ATSDR (2003)). Moreover, marked decrease in fertile capacities, the number of fetal animals per 1 litter, the number of survival during pregnancy and after birth and post delivery body weight can be observed among females administered with a dose of 685mg/kg in the reproductive toxicity study via drinking water administration using mice. It has been summarized that these effects result from marked toxicity (liver hypertrophy, death) of parent animals and at the dose level where toxicity is not found in parent animals there will not be any considerable effect on genital organs. (ATSDR (2003) Based on the above-mentioned, it was classified into "Not classified".
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects) Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
From a description that enervation and ataxia are seen in the oral administration test employing rats. (NTP TR282 (1985), ATSDR (2003)), it was classified into Category 3 (Narcotic effects)
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In one month mixed feed administration test during employing rats, the increase in liver relative weight, vacuolization and swelling increase of hepatic cells, and the unicellular necrosis of hepatic cells were seen, and the significant differences were observed in total cholesterol, increase in alkaline phosphatase activity ( MOE Risk Assessment, Volume 6 (2008). Moreover, in 90 days forced oral administration test employing rats, the increase in the degeneration incidence rate in nephric tubule in the male and female, and the fat (vacuolar) degeneration of the hepatic cells in the centrilobular region were seen in the male (MOE Risk Assessment, Volume 6, ATSDR (2003)). Moreover, there is a description that the fatty degeneration of liver cells in male in 13-weeks forced oral administration test employing rats, the increase in the incidence rate of the fatty degeneration and and cloudy hyaline degeneration of liver cells in male and female and increase of nephropathy in male in 104-weeks forced oral administration test, were seen, (MOE Risk Assessment, Volume 6 (2008), NTP TR282 (1985)). Since the effects on liver and kidney were seen within the range of the guidance value of Category 2, it was classified into Category 2 (liver, kidney).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 72 hours EC50=9.6mg/L of the algae (Pseudokirchneriella subcapitata) (MOE eco-toxicity tests of chemicals (1995)).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 2 and there were no rapid degradability (BIOWIN), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information