GHS Classification Result

Chemical Name:2,4-Di-tert-butylphenol
CAS:96-76-4

Result:
ID: 1-208
Classifier: Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition temperature 330degC (IUCLID,2000)).
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
From LD50 value 1,762 mg/kg (Health, Labor and Welfare Ministry report (Access on October 2008)) of the acute oral toxicity test (OECD TG 401, GLP) employing a rat, it was classified into Category 4.
1 Acute toxicity (Dermal) Not classified - - - - Although LD50 value 2,200 mg/kg of the dermal administration test employing a rabbit (RTECS (2004)) corresponded to the U.N. GHS acute toxicity Category 5, it fell under unadopted category in Japan and was classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Since there is s description, "irritation (redness: 3.0, irritation index: 3.88/8)" (IUCLID (2000)) in the skin irritation/corrosion test with rabbits (OECD TG 404), it was classified in Category 2.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Since there is a description of "irritation (conjunctiva redness: 2.06, iris: 1.00, cornea: 1.61, irritation index; 38.5/110)" (IUCLID (2000)) in eye irritation/corrosion test employing rabbits (OECD TG 405), it was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Although it has been described as "no sensitizing potential" (IUCLID (2000)) in the Maximization test employing 20 guinea pig (OECD TG 406), classification is not possible because of no other data.
5 Germ cell mutagenicity Classification not possible - - - - Although for the in vitro mutagenicity test, it is described as "chromosome aberration test employing a Chinese hamster culture cells: positive, the mutagenicity test employing the bacteria: negative" (Health, Labor and Welfare Ministry reports (Access on October 2008)), classification is not possible because there is no data of in vivo examination.
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 2 (kidney) Warning H371: May cause damage to organs (kidney) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
It has been described as "The ash gray point or hypertrophy of the kidney macroscopically, and basophilic nephric tubule histologically, granular cast, neutrophilic cell infiltration, mineral deposition, etc., have been observed and it has been suggested to affect the kidney" in the oral administration test employing rats (Health, Labor and Welfare Ministry reports (Access on October 2008)). Since these symptoms were seen within the range of the guidance value of Category 2, it was classified into Category 2 (kidney).
9 Specific target organ toxicity - Repeated exposure Category 2 (kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Since in 28-day repeated oral administration test in rats (Guideline for 28-Day Repeated Dose Toxicity Test in Mammalian Species (Chemical Substances Control Law of Japan), GLP), "enlargement and gray points of the kidney, basophilic tubule, granular cast, distal convoluted tubule extension, and proximal convoluted tubule enlargement (Ministry of Health, Labour and Welfare reports (Access on October 2008)) were found within the scope of the guidance value of Category 2, it was classified into Category 2 (kidney). Although "the increase in liver weight and centrolobular hypertrophy of hepatocytes" are also described in this study (Ministry of Health, Labour and Welfare reports (Access on October 2008)), it was not adopted since it is not considered serious effect. Moreover, "decrease in amount of hemoglobin, drop in hematocrit, increase in segmented neutrophil rate, and prolongation of prothrombin time and APTT were found" (Ministry of Health, Labour and Welfare reports (Access on October 2008)), however, it is written that these were "not classified into serious changes," but as "changes relevant to effects on the kidney", therefore, it was not adopted for the classification evidence.
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 48 hours EC50=0.33mg/L of the crustacea (Daphnia magna) (MOE eco-toxicity tests of chemicals (2004)).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 1 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 0% (standard test method (4 weeks)) (Existing Chemical Safety Inspections Data (1987))), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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