Chemical Name：N,N-Dicyclohexan-1-yl(1,3-benzothiazol-2-ylsulfanyl)amine
CAS：4979-32-2

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Although in the Health, Labor and Welfare Ministry reports (Access on October 2008), LD0 values of the oral administration test (OECD TG 401, GLP) employing a rat were 1,821 mg/kg (male) and 1,077 mg/kg (female), the dose correlation was not found. However, LD50 values are estimated to be >= 1,821 mg/kg (male) and >= 1,077 mg/kg (female). Moreover, LD50 value >5,000 mg/kg and 6,420 mg/kg of the oral administration test employing a rat are shown in SIDS (2004). Furthermore, Patty (5th, 2001) describes that "LD50 value of acute toxicity (oral) is >5,000 mg/kg." . As mentioned above, LD50 value 6,420 mg/kg that was a definite value was adopted, and it was classified into "Not classified".
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	From a description of LD50 value of >2,000 mg/kg (SIDS (2004), Patty (5th, 2001), IUCLID (2000)) in the dermal administration test employing rabbits, it was classified into "Not classified".
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	Classification not possible due to lack of data
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Classification not possible due to lack of data
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	Although there is a description, "moderate skin irritation" (SIDS (2004))in the 24 hour Draize test using rabbits, classification is not possible, because it is the result under a severer condition than 4 hours.
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	SIDS (2004) has described as "Not irritating" in the eye irritation test employing rabbits and as "slightly" in Draize test. As a conclusion, since SIDS (2004) has described as "slightly irritating to eyes in rabbits", it was classified into "Not classified".
4	Respiratory sensitization	Classification not possible	-	-	-	-	Classification is not possible since there is no data.
4	Skin sensitization	Not classified	-	-	-	-	There is no data about humans. There is a description of "Not sensitizing" in the Maximization tests employing guinea pig (SIDS (2004), IUCLID (2000)), and it has been concluded that "there is no skin sensitizations" in SIDS (2004). Moreover, it was classified into "Not classified" since it has been concluded that "this substance is not a skin sensitizer" in Patty (5th, 2001) as well.
5	Germ cell mutagenicity	Not classified	-	-	-	-	Since there is a description that the body cell in vivo mutagenicity test (chromosome aberration test (GLP) employing rats bone marrow cell) was "negative" (SIDS (2004)), it was carried "Not classified".
6	Carcinogenicity	Classification not possible	-	-	-	-	Since no evaluation by major international evaluation agencies is made and there is a conclusion that "there is no research example with sufficient evidence" (SIDS (2004), Patty (5th, 2001), IUCLID (2000)), classification is not possible.
7	Reproductive toxicity	Classification not possible	-	-	-	-	It is reported in a Ministry of Health, Labor and Welfare Report (Access on October 2008), SIDS (2004) that in a combined repeated dose toxicity study and reproductive/developmental toxicity screening study in rats (OECD TG 422, GLP), "no changes in the rates of copulation and conception were observed, and it was judged that there were no effects." Moreover, for effects on fetuses and neonates and abnormalities in delivery and rearing at doses at which toxicities manifest themselves in mother animals, it is reported that "general toxicological effects are thought to be the greatest." However, in this study the data on teratogenicity in the offspring is insufficient. Since there is no other experimental data, classification is not possible.
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system)		Warning	H371: May cause damage to organs (central nervous system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	In the acute oral toxicity test employing a rat (OECD TG 401, GLP), "As symptoms, diminished locomotor activity, deep respiration, nerve tremor, spasm, etc., were observed. There is a description that these symptoms has recovered in the living animal on and after 7th day."(Health, Labor and Welfare Ministry reports (Access on October 2008)). Since this effect was seen within the range of the guidance value of Category 2, it was classified into Category 2 (central nervous system).
9	Specific target organ toxicity - Repeated exposure	Category 2 (kidney, adrenal gland, thymus, central nervous system, respiratory system)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (kidney, adrenal gland, thymus, central nervous system, respiratory system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	It is written in the combination test of repeated dose toxicity study and reproduction screening study in rats (OECD TG 422, GLP) that there was PAS positive hyaline droplet in proximal tubular epithelium of the kidney in males, and enlargement and fading of the kidney ,fatty degeneration of proximal tubular epithelium of the kidney, enlargement and fading of the adrenal gland, tabefaction, and decrease in locomotor activity in females, in addition, thymic atrophy in males and females"" (Ministry of Health, Labour and Welfare reports (Access on October 2008)). These effects were found within the scope of the guidance value of Category 2. Moreover, it is written in repeated inhalation exposure test in rats that "the irritation to mucosa is caused" (SIDS (2004)), and this effect was found within the scope of the guidance value of Category 2. Therefore, it was classified into Category 2 (kidney, adrenal gland, thymus, central nervous system, and respiratory system).
10	Aspiration hazard	Classification not possible	-	-	-	-	Classification not possible due to lack of data