Chemical Name：3-(3,5-Dichlorophenyl)-5-methyl-5-vinyl-1,3-oxazolidine-2,4-dione
CAS：50471-44-8

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	From a description of LD50 value of >15,000 mg/kg (JMPR (1995)) in the oral administration test employing rats, it was classified into "Not classified".
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Since LD50 value of the dermal administration test employing rats was >5,000 mg/kg (JMPR (1995)), it was classified into "Not classified".
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	Classification not possible due to lack of data
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	It is a solid whose saturated vapor pressure level at 20degC is 1.8*10^-6 mg/L. Although LC50 value of the inhalation exposure test employing rats is >29.1 mg/L (JMPR (1995)), classification is not possible since exposure time is unknown.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	Although there is a description of slight, momentary irritation in the 24 hour dermal stimulation study with 50% liquid using rabbits (JMPR (1995)), classification is not possible, because the liquid is not 100% and the study time is out of standards.
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	From a description of "not irritating to the eyes" in the eye irritation test employing rabbits (JMPR (1995)), it was classified into "Not classified ".
4	Respiratory sensitization	Classification not possible	-	-	-	-	Classification is not possible since there is no data.
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	It was classified into Category 1 from a description of "suggesting sensitizing" (JMPR (1995)) in the Maximization tests employing 12 male guinea pig. In addition, it can be classified as R43 (EU-AnnexI) in the European Union classification, which is equivalent to Category 1.
5	Germ cell mutagenicity	Not classified	-	-	-	-	It was classified into "Not classified" from the description of negative (JMPR (1995)) in the in vivo heritable mutagenicity test (dominant lethal test employing a mouse) employing a germ cell. Moreover, there are also descriptions of negative (NTP DB (Access on October 2008)) in the in vivo genotoxicity test (SCE test employing a hamster spermatogonium) employing a germ cell and negative (JMPR (1995)) in the in vivo mutagenicity test (micronucleus test using mouse peripheral blood) employing a somatic.
6	Carcinogenicity	Category 2		Warning	H351: Suspected of causing cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Since the European Union classification was Cat. 3; R40 (EU-Annex I), and it was described that the 18-month oral administration test employing male and female mouse showed liver cell cancer and the 24-month oral study employing male and female rats showed Leydig cell tumor, adenoma in adrenal gland (JMPR (1995)), etc., it classified into Category 2.
7	Reproductive toxicity	Category 1B		Danger	H360: May damage fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In an oral multigenerational study in rats (JMPR (1995)) it is reported that the substance caused infertility in males due to feminization of external reproductive organs in the F1 generation male offspring (100 mg/kg group) at doses at which general toxicity is not observed in mother animals, suggesting that the substance served as an androgen receptor antagonist. For the reasons stated above, it was classified as Category 1B. It is also reported that 12 out of 15 animals which were administered 800 mg/kg miscarried in an oral administration study in rabbits (JMPR (1995)). Incidentally, the EU classification is Cat. 2; R60-61 (EU-Annex I), and it is equivalent to Category 1B in GHS.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	Classification not possible due to lack of data
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, kidney, adrenal gland)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney, adrenal gland)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	There are descriptions of the necrosis, hypertrophy of liver, tissue disorder of adrenal gland (JMPR (1995)), etc., and of the lipid droplet of the distal convoluted tubule of the kidney, extension of a kidney pelvis, a water ureter (IRIS (1992)), etc., in the repeated oral administration test employing mice, rats, and dogs. Since these influences were seen within the range of the guidance value of Category 2, it was classified into Category 2 (liver, kidney, adrenal gland).
10	Aspiration hazard	Classification not possible	-	-	-	-	Classification not possible due to lack of data

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 5 days EC50=0.9 mg/L of the aquatic plant (Lemna Gibba) (AQUIRE (2008)).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and there were no rapid degradability (BIOWIN), it was classified into Category 1.