GHS Classification Result

Chemical Name：2,5-dichloroaniline
CAS：95-82-9

Result：
ID: 1-156-3）
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition temperature 540degC (IUCLID,2000)).
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - It is an organic compound not containing oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		From LD50 value 1,600 mg/kg of the oral administration test employing a rat (HSDB (2003)), it was classified into Category 4. In addition, EU classification of 3,4-Dichloroaniline (CAS No.95-76-1) which is a constitutional isomer is T;23/24/25 (EU-Annex I).
1 Acute toxicity （Dermal） Classification not possible - - - - Classification is not possible because there is no data. In addition, EU classification of 3,4-Dichloroaniline (CAS No.95-76-1) which is a constitutional isomer is T;23/24/25 (EU-Annex I).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification is not possible because there is no data. In addition, EU classification of 3,4-Dichloroaniline (CAS No.95-76-1) which is a constitutional isomer is T;23/24/25 (EU-Annex I).
2 Skin corrosion/irritation Classification not possible - - - - Although there is a description, saying, "It is not an irritating substance against rabbit's skin,"(BUA 140 (Summary, 1993)), classification is not possible because data are insufficient.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		From the description of "The effect which is severe and is not completely recovered on the eyes of a rabbit" (BUA 140 (Summary, 1993)), it was classified into Category 1. In addition, the EU classification of 3,4-Dichloroaniline, which is a constitutional isomer, is Xi; R41 (CAS No.95-76-1) (EU-Annex I).
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		The substance was classified as Category 1 from descriptions that "it is a methemoglobin formation substance, and indicates weak skin sensitizing potential" (Patty (5th, 2001)) and that "bad skin sensitizing potential" (BUA 140 (Summary 1993)) in the Maximization tests employing guinea pig. In addition, 3,4-Dichloroaniline (CAS No.95-76-1) which are constitutional isomers can be classified as R43 (EU-AnnexI) in the European Union classification.
5 Germ cell mutagenicity Classification not possible - - - - Although there are descriptions of "negative" in the in vitro reverse mutation test employing Salmonella typhimurium (NTP DB (Access on January 2009)) and "negative" in chromosome aberration test employing V79 cell and in the UDS test employing hepatic cells (BUA 140 (Summary, 1993)), classification is not possible because there is no data of in vivo examination. In addition, also refer to the classification of 3,4-Dichloroaniline (CAS No.95-76-1) which is a constitutional isomer.
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - Although there is a description as follows in SIDS (2005), "In the short-term repeated study with 2-chloroaniline and 2,5-Dichloroaniline no effect was found on male genital organs, " classification is not possible, because there is no other datum.
8 Specific target organ toxicity - Single exposure Category 2 (blood system) Warning H371: May cause damage to organs (blood system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The information source of List1 have a description that "3,4-, 2,4-, 2,5-Dichloroaniline are methemoglobin formation substances" (EU-RAR (2006)). Moreover, the information source of List2 has a description that "cyanosis, a feeling of fatigue, dyspnea, and a muscular power fall were shown as acute symptoms by methemoglobinemia" (BUA 140 (Summary, 1993)), and another description that "the effect by increases of methemoglobin values and decrease of transport an blood oxygen rate is reported" (HSDB (2003)), therefore, it classified into Category 2 (blood systems). In addition, ICSC (2000) has a description that "this article may affect blood by effect of the methemoglobin formation."
9 Specific target organ toxicity - Repeated exposure Category 2 (blood system) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		There are reports of "hemolytic anemia and elevated total bilirubin levels, and in females, increased erythrocyte production in the bone marrow and hemosiderosis in the lien in males of 150 and 750 mg/kg dose groups in a 28-day oral administration study in rats," and "3,4-, 2,4- and 2,5-Dichloroaniline are methemoglobin-forming substances" in EU-RAR (2006), so it was classified as Category 2 (blood system).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48 hours EC50=1.8mg/L of the crustacea (Daphnia magna) (Environmental Agency eco-toxicity tests of chemicals (2000)).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 2 and there were no rapid degradability (not readily degradable, the decomposition by BOD(standard test method (2 weeks)): 0% (Existing Chemical Safety Inspections Data (1979)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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