GHS Classification Result

Chemical Name：3,4-Dichloroaniline
CAS：95-76-1

Result：
ID: 1-156-2）
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition temperature 269degC (ICSC,2000)).
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - Although it is an organic compound including chlorine, not fluorine and oxygen, chlorine has bound only to carbon.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		From description of LD50 value 570 mg/kg (male, OECD TG401), 880 mg/kg (buck), and 530 mg/kg (female) (EU-RAR (2006)) of the oral administration test employing a rat, since all the values corresponded to Category 4, it was classified into Category 4. In addition, in EU classification, T; 23/24/25 (EU-Annex I).
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		EU-RAR (2006) describes LD50 value >1,000 mg/kg of the dermal administration test employing a rat and LD50 value 631
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Since it is written in EU-RAR (2006) that LC50 values of 4-hour aerosol inhalation exposure test employing rats are >0.631 mg/L (OECD TG403), and 3.3 mg/L, it was classified into Category 4 based on the definite value 3.3 mg/L.. In addition, in EU classification, T; 23/24/25 (EU-Annex I).
2 Skin corrosion/irritation Not classified - - - - Since there are descriptions, "slightly irritating, erythema grade 1, recovery within 2 days" (EU-RAR (2006), IUCLID (2000)) in the Draize test using rabbits (OECD TG404, GLP) and "not irritating" (IUCLID (2000)) in the 24 hour skin irritation test using rabbits, it was classified into "Not classified".
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		There is a description of "moderate irritation, recover within 14 days", in the eye irritation test of a rabbit in EU-RAR (2006) and in the Draize test of the eyes of a rabbit (OECD TG405) "mild. Average score after 24, 48, and 72 hours: conjunctival redness 1.7/2/2, conjunctival edemas 0.7/0.7/1.3, stimulus to the iris 1/0.7/0.3, and corneal opacity 1.3/1/0There is a description of "These resilience has not been described." In both of the tests, "The corneal vascularization which will not be recovered for 14 days" is seen and although there was a description of "the serious damage on an eye is caused", since recoverability after 21 days was unknown, it was classified into Category 2A. In addition, it can be classified as Xi; R41 (EU-Annex I) in the EU classification based on these test results.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		It was classified as Category 1 from description that "75% were positive" (EU-RAR (2006), IUCLID (2000)) in the Maximization tests employing 20 guinea pig (OECD TG406, GLP) not humans data. In addition, it can be classified as R43 (EU-AnnexI) in the European Union classification based on this test result. Moreover, it can be classified as Sh (ACGIH-TLV/BEI (2006)) in the German MAK list.
5 Germ cell mutagenicity Not classified - - - - From a description of "negative" (EU-RAR (2006)) in the body cell in vivo mutagenicity test (micronucleus test employing the mouse bone marrow cell), it was classified into "Not classified". Moreover, as an in vitro mutagenicity test, there are descriptions of "negative" in the reverse mutation test employing the Salmonella typhimurium (NTP DB (Access on January 2009)) and of "negative" in the chromosome aberration test employing humans lymphocyte (EU-RAR (2006)).
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible. In addition, EU-RAR (2006) has a description that "carcinogenicity data on 2,5-Dichloroaniline, 2-chloroaniline and 3-Chloroaniline were not obtained, but 4-chloroaniline has carcinogenicity with rats and mice. There is a concern that this substance which has a similar structure of 4-chloroaniline may also be carcinogenicity." Moreover, 4-chloroaniline is classified in group 2B by IARC (IARC 57 (1993)), and Cat.2; R45 by European Union classification (EU-Annex I).
7 Reproductive toxicity Classification not possible - - - - Although there are descriptions as folows in EU-RAR (2006), "Although resorption and embryo losses after implantation were found at the dose level (125mg/kg) where suppression of the body weight increase and reduction in food consumptions with mother animals can be observed in the pre-birth developmental toxicity study via oral administration (OECD TG 414) using rats of 6-15 day prgnancy, there was no statistical significance and teratogenicity was not confirmed," and "There was no change in the absolute weight and relative weight of testis and no histopathologic change of testis and situ of the testis with exposures up to 0.2mg/L "in the study with male rats by inhalation exposure for 2 weeks, classification is not possible, because there is no data on reporoductive capacities nor reproductive performances.
8 Specific target organ toxicity - Single exposure Category 1 (blood system) Danger H370: Causes damage to organs (blood system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Patty (5th, 2001) has a description of "cyanosis, a feeling of worthlessness, breathing difficulty, and loss of muscle strength" as acute conditions to animals and humans, and EU-RAR (2006) has a description that "an initial toxic effect is methemoglobin formation like other Chloroaniline. The cyanosis, a feeling of fatigue, dyspnea, and a muscular power fall were indicated as acute symptoms by methemoglobinemia." Moreover, as for animals, the inhalation exposure test which employed rats showed that "a deep sleep, the abnormalities in a walk, an ataxic gait, and a rise of methemoglobin level" (EU-RAR (2006)) were seen within the limits of Category 2 from Category 1. As mentioned above, it was classified into Category 1 (blood systems).
9 Specific target organ toxicity - Repeated exposure Category 2 (blood system) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		"Coordination deficit of muscle, increase in serum methemoglobin level, the number of red blood cells, LDH, dysfunction of the liver (increase in BSP level), kidney damage (increase in BUN level) in the administered group of 20 mg/kg" are described in 6-month oral administration test in rats (IUCLID (2000)). Moreover, since it is written that "3,4-, 2,4-, 2,5-Dichloroaniline is methemoglobin formative substance" (EU-RAR (2006)), it was classified into Category 2 (blood systems). In addition, about "hepatic dysfunction and injury to the kidney", since it was unspecified, it was excluded from target organs.
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48 hours EC50=0.23mg/L of the crustacea (Daphnia magna) (EU-RAR (2006)).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 1 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 0% (standard test method) (Existing Chemical Safety Inspections Data (1979))), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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